2 new interesting workout supplements

[dbailey11]

I was reading through Musclmag the the other day and they have a section research drugs where they talk about potential new supplements for body building. The two that interested me were 1-phenyl-2-propylaminopentane and one that is already sold OTC in Europe as a pain reliever.

I couldn't much info on the first chem when I Googled it; so I'm wondering if there's an alternative name for it. It's being studied right now as a CNS. I was wondering if anyone had heard of it and had any more info on it.

The famprofazone is an analgesic and is not scheduled in Europe.
There's some interesting info on it here.

 

[Ham-milton]

1-phenyl-2-propylaminopentane is known as PPAP, a known stimulant that's an effective aid to learning and memory.

famprofazone is a NSAID that breaks down into d,l amphetamine and d,l methamphetamine. It's probably the most interesting NSAID, i'm afraid. Doesn't seem to have much stimulant effect. I think you'd have to take quite a bit.

Not quite sure what you mean when you say PPAP is "being studied as a CNS"

 

[dbailey11]

CNS= central nervous stimulant

 

[johanneschimpo]

CNS = central nervous system

 

[Ham-milton]

If you mean what you obviously mean (now I can understand) you need two (2) S's. You mean "Central Nervous System Stimulant"- but no one is going to understand "CNSS" say either "stimulant" or "CNS stimulant" because what you're writing makes no fucking sense at all.

Anyway, about the drugs-

are these available in supplements in the US?

 

[vecktor]

PPAP is touted as a 'monaminergic tone increaser' it seems to increase both reuptake and release in NE DA and SE neurons. the Related substance BPAP is more effective but unlike PPAP is probably high hepatotoxic.
the cathinone with the pentane skeleton is found naturally in some samples of Khat : catha edulus.

 

[LuxEtVeritas]

^

these are not naturally occurring and therefore certainly not candidates for any (legal) US dietary supplement

BPAP to my knowledge has been founf to not have adverse effect which i believe include lack of hepatotoxicity

 

[vecktor]

^

BPAP to my knowledge has been founf to not have adverse effect which i believe include lack of hepatotoxicity

interesting, it has the correct structure for hepatotoxity. I was aware it was being investigated in Germany but seems to have fallen off the radar.

 

[dbailey11]

Well I read they were studying for a possible new supplement (the PPAP)for energy/focus. Would it be anything that's euphoric?

It's weird that the famprofazone breaks down into amphetamine and methamphetamine, but in itself is a pain reliever.

 

[LuxEtVeritas]

as to PPAP's effect think similar to deprenyl but not an MAOB-I...not euphoric

amph and Meth in and of themselves can be analgesic to note

again no one can study it for a supp as it is not compliant for such...those magazines are 95% BS tripe

 

[mad_scientist]

interesting, [BPAP] has the correct structure for hepatotoxity. I was aware it was being investigated in Germany but seems to have fallen off the radar.

What is it about the structure of BPAP that would make you think its going to be hepatotoxic? Can't see any structural elements I'd be particularly worried about, would you mind explaining your concerns?

 

[vecktor]

What is it about the structure of BPAP that would make you think its going to be hepatotoxic? Can't see any structural elements I'd be particularly worried about, would you mind explaining your concerns?

I hit it through METEOR, it has a benzothiophene substituted in the heterocycle,and it suggested that the metabolism might involve cleavage of the thiophene ring at the sulphur leading to reactive intermediates. in the same way as the hetero substituted benzofurans.
METEOR is not infallable by a long stretch though.
I would like to run it through DEREK but I don't have access.

 

[LuxEtVeritas]

notably there are many compounds that do exert hepatatoxicity at low doses though that this compound probably has a therapeutic dose of perhaps ~1mg I would think makes it less likely to be hepatotoxic at that required dose

 

[Ham-milton]

Although Famprofazone is a NSAID, it's metabolites (amp and mamp) are strong analgesics in their own right. I think I read somewhere that amphetamine was roughly equipotent as an analgesic compared to morphine, so 5mg amphetamine = 5mg morphine analgesically.