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2-Methylamino-1-p-tolylpropan-1-one?

IMHO that certificate of analysis is a incomplete joke.
no proper information, no spectra no retention time no absorbance values no hplc conditions utter useless crap.
 
well it is not even a credible independent third party purity test so even in that regard it is worth less than the paper it is printed upon
 
It is quite obvious that it isn't, so stop trying to bullshit us. It's just a piece of paper that someone wrote a percentage of purity on and as no analytical data is attached it is impossible to do any identification.

How can we be assured that the compound offered is indeed p-methyl-methcathinone and not N-ethyl-cathinone when you don't know the structural difference? Everything about this whole mess smells very fishy to me.
 
Usually you get only a certificate of analysis unless you ask for more details. It's bad practice by the producer/distributor IMO, and the raw analytical data should be attached.

Winta: Considering the way this discussion has gone, you should probably get a GC/MS or NMR (analyzed in a domestic laboratory) of the material and post it here, if you want the crowd here to be assured you are talking about the correct compound.
 
^ Or at least treat a small sample of it with a vigourous oxidizer - ethcathinone results in benzaldehyde, the subject of this thread would result in p-tolualdehyde (this is dependant upon benzaldehyde & p-tolualdehyde having different, distinguishable smells)
 
Please do not post the name of the analyst. It doesn't do anything to answer the question anyway.
 
Assuming you get anything at all, I seriously doubt you will get anything more than a single chromatogram on which someone has scribbled something unintelligible or just an arrow near the major peak. If you do in fact get a reference chromatogram that shows a standard injected to determine retention time, you still have no real way of knowing if the standard was ethylcathinone or p-tolylmethcathinone, or for that matter even something else altogether. All that will tell you is you have a sample that has a peak that corresponds to the RT of *some*standard.

As has been suggested, unless you get either GC/MS, NMR, or a small series of standard qualitative organic analyses performed, you are not going to know what you really have.
 
Mass seems to fit,chromatogram looks ok.One caveat though,Ethcathinon has the same mass as the title compound.So one has to believe the supplier the identity.
 
What's with the retention time? On the ESI it says 7.55, on the other 8.046 for the major peak.

Anyone else tried this yet? Any more concerns about safety?
 
nuke said:
Pyrovalerone has little/no serotonergic action iirc, though I'm not sure it's been totally evaluated. It's not an often used stimulant.

The drugs are relatively safe with occasional use, I think DOB/DOB-dfly have high affinity for 5HT2b but I haven't heard of people developing cardiac fibrosis from it. 5HT2b stimulation was the reason the drugs fenfluramine, 4-methylaminorex, methamphetamine (not to mention its abuse potential), methysergide and pergolide were removed from the market/scheduled. Oddly ergotamine and cabergoline are still available. LSD also is a moderate 5HT2b agonist.

In the future such prolactin-inhibiting ergolines may be supplemented with 5HT2b antagonists, or perhaps newer more specifically dopaminergic compounds will be available. It makes me worry sometimes about the users of hydergine, that they might develop some sort of cardiac problems.
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One thing to note: Fen Phen was a combination of two drugs, Fenfluramine (which is an 5HT2b agonist, and Phentermine, which was an MAOI. I don't really have to tell all of you what happens when you combine a seritonin agonist with an MAOI.

In fact, fen phen was never approved as a combo. Somehow, doctors got word (via the drug companies illegally telling them that this combo could help with obesity or other doctors), and started perscribing it off label for obesity. However, it was never stated on the label that Phentermine was an MAOI, so who was to know that this could cause such a toxic potential. Therefore, one idea about fen-phen toxicity is not either drug by itself, but rather the dangerous combination of both that was assumed to be fine due to non-disclosure of pharmacology by the pharm companies.

I don't think there have been any cases of fenfluramine toxicity by itself. I think it needs either extremely high doses over long periods of time, or potentiation by an MAOI. Therefore, unless something has a really high affinity for 5HT2b, and is a really strong agonist, there probably shouldn't be a problem. However, since the drug has been pulled--who knows.
 
Looking at the spectra:

178 is the quasi-molecular parent ion [M+H]+
179 is the quasi-molecular parent ion [M+H]+ arising from naturally occurring C13 isotopic content.
160 is the [M+H - H2O]+ ion resulting from water loss at the ketone.

Electro-spray ionization does not give you enough carbon fragmentation to distinguish between p-tolyl or ethcathinone. An EI spectra might give you more info.
 
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SynAmnesia said:
One thing to note: Fen Phen was a combination of two drugs, Fenfluramine (which is an 5HT2b agonist, and Phentermine, which was an MAOI. I don't really have to tell all of you what happens when you combine a seritonin agonist with an MAOI.

In fact, fen phen was never approved as a combo. Somehow, doctors got word (via the drug companies illegally telling them that this combo could help with obesity or other doctors), and started perscribing it off label for obesity. However, it was never stated on the label that Phentermine was an MAOI, so who was to know that this could cause such a toxic potential. Therefore, one idea about fen-phen toxicity is not either drug by itself, but rather the dangerous combination of both that was assumed to be fine due to non-disclosure of pharmacology by the pharm companies.

I don't think there have been any cases of fenfluramine toxicity by itself. I think it needs either extremely high doses over long periods of time, or potentiation by an MAOI. Therefore, unless something has a really high affinity for 5HT2b, and is a really strong agonist, there probably shouldn't be a problem. However, since the drug has been pulled--who knows.
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Phentermine is much more than just an MAOI, though. I don't even know if it's MAO inhibition properties are all that strong. Amphetamine is a mild MAOI in its own right, for that matter.
 
Was gonna say, freaked me out for a second! Though i've never combined it with anything, feels pretty much like amphetamine to me.
 
Phentermine is a piss-poor competetive inhibitor, like amphetamine (and has no real clinical significance). If you'd taken a full on inhibitor of MAO, be it competetive or non-competetive with fenfluramine,pulmonary hypertension would be the least of your worries - a more immediate danger would be hyperthermia & associated conditions like muscle breakdown & clotting problems because the thermostat in the brain just keeps getting reset higher & higher when overflooded with 5HT
 
So, back to the chemical at hand: para-methyl-methylcathinone. First, did I perhaps miss something about the structure or pharmacology of this compound? Everyone seems to assume that it is a potent 5-HT2B receptor agonist--where did that theory come from? Methylcathinone itself is not known for 5-HT2B agonist effects, is it?

I realize that 4-position substituents on the amphetamine skeleton are not usually friendly (save 4-fluoroamphetamine). In general, a 4-substituent confers serotonergic activity, but not necessarily 5-HT2B agonism. Since the beta-keto amphetamines have a greater propensity to inhibit monoamine uptake than act as releasers (as opposed to the pure amphetamines, which tend to act purely as releasers), it may have strange effects on the SERT, but individual receptors?

Any other reports? From the one trip assessment out there, it sounded at least as fun as a barrel of monkeys, if not more so. But all the talk of cardiac toxicity and MAOI activity would have me worried.

PS: And F&B is right, phentermine is not an MAOI--it is a more noradrenergic version of amphetamine (I personally can't stand it; it certainly doesn't 'feel' as if it causes functional dopamine release in vivo).
 
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Because I keep wondering what it looks like every time I see it, here is the art...

n-ethyl-para-methylcathinone.bmp


I wonder which is the active isomer. ANyone know with regards to PMA? Does that follow the stimulant model (S being the active one) or the psychedelic (except for MDMA) where the R is the more active? Perhaps, this would be just as PMA was.
 
I'll never get tired of M1 (although once a year is plenty for me.) It's a very useful stuff. Never tried any other cathinone analogues...none that are available really interest me except the real one (khat) and some of the MDMA analogues.

Now I do wish cathinones of the 2Cs could appear...those would be interesting to meet.
 
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