• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

2-Methylamino-1-p-tolylpropan-1-one?

slopoke

slopoke

Bluelighter
Joined
Mar 11, 2004
Messages
1,023
Location
Manchester
Can anyone identify this for me please, i am CRAP when it comes to chem identification, sounds like it might be active though, no?

TIA :)
 
its just p-methyl methcathinione.

p-methyl amphetamine was explored by Rothman, et al. not too long ago so I imagine it is to that what methylone is to MDMA.
 
Thanks for the swift response, Does this mean this is like the cathinone cousin of PMMA?

EDIT: silly me that would be methoxy not methyl
 
I'm sure it'd be active, but I'm not certain it's something I'd want to eat. cathinone analogues of amphetamines never seem to live up to expectations.
 
Ham-milton said:
I'm sure it'd be active, but I'm not certain it's something I'd want to eat. cathinone analogues of amphetamines never seem to live up to expectations.
Click to expand...

Actually it definitely has been tasted and is active. However from what I remember from some now lost personal communication with the person who tasted it, the initial euphoria has a tendency to go off the boil very quickly.
 
Reports back from The Hive indicate that this compound may be very well worth the effort, with bouts of great euphoria (although the reports were only from an isolated user and his personal friends if I remember correctlY). Isn't there anyone here who has personal experience to share?
 
If I remember correctly it was you who mentioned in some other thread several months ago that you were about to try this compound. Never got around to do it?

For pharmacology retarded persons like me, what is meant when thinking 5HT2b receptor? :D
 
5HT2B agonism often causes very negative cardiac problems eg fibrosis in chronic usage.
 
neuwelt said:
If I remember correctly it was you who mentioned in some other thread several months ago that you were about to try this compound. Never got around to do it?

For pharmacology retarded persons like me, what is meant when thinking 5HT2b receptor? :D
Click to expand...

No not that, but alpha-pyrrolidinopropiophenone or N-ethylcathinone, both of which don't have that potential problem
 
Thanks!
Well, if it's only a potential problem with chronic use then doing it everynow or then shouldn't pose any problem really or? So this has to do with the alkyl substituent on the phenyl ring, but how come pyrovalerone was marketed (I do not know if it still is prescribed, not mentioned on Wikipedia)?

Did you try alpha-pyrrolidinopropiophenone? If so how was your experience? That's another stimulant there sadly is very little empirical data upon, but which looks promising (and still legal pretty much everywhere except in Germany).
 
Pyrovalerone has little/no serotonergic action iirc, though I'm not sure it's been totally evaluated. It's not an often used stimulant.

The drugs are relatively safe with occasional use, I think DOB/DOB-dfly have high affinity for 5HT2b but I haven't heard of people developing cardiac fibrosis from it. 5HT2b stimulation was the reason the drugs fenfluramine, 4-methylaminorex, methamphetamine (not to mention its abuse potential), methysergide and pergolide were removed from the market/scheduled. Oddly ergotamine and cabergoline are still available. LSD also is a moderate 5HT2b agonist.

In the future such prolactin-inhibiting ergolines may be supplemented with 5HT2b antagonists, or perhaps newer more specifically dopaminergic compounds will be available. It makes me worry sometimes about the users of hydergine, that they might develop some sort of cardiac problems.
 
Last edited:
Well I don't know enough about 5-HT2b receptors to contribute but found this on wikipedia [I know not very scientific but still...]

http://en.wikipedia.org/wiki/Fenfluramine

The drug was withdrawn from the U.S. market in 1997 after reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis.

The distinctive valvular abnormality seen with fenfluramine is a thickening of the leaflet and chordae tendinae. Roth[2] suggested a mechanism by which fenfluramine damaged the valves. Heart valves also have serotonin receptors, which regulate their growth. He reported that fenfluramine and its active metabolite norfenfluramine stimulated the serotonin receptors 5-hydroxytryptamine (5-HT). In particular norfenfluramine is a potent agonist (stimulant) of 5-HT2B receptors. These receptors are plentiful in human cardiac valves and appear to be essential for normal cardiac development. Roth suggested that the mechanism by which fenfluramine causes damage is through inappropriately stimulating the valve cells to divide. This valve damage is found in other drugs that act on 5-HT2B receptors.
Click to expand...

^chronic use as suggested above though.
 
does a 5-HT2B agonist have desirable effects in the brain...perhaps then a peripheral antagonist if that is the case would be optimal for any drug that causes 5-HT2B agonism
 
Are you sure the supplier have labelled the product correctly?
Reports from The Hive tells that 400 mg in one night is a quite huge dosage, and that for someone with 'abuse' issues, i.e high tolerance. What was your initial dose? Was the total amount spaced out over 12 hours, i.e approximately 100 mg per hour?

Also I noted from a photo on another forum that the label shows n-ethyl-cathinone/ethcathinone, and not p-methyl-methcathinone.

If it really is p-methyl-methcathinone 1.4g may not be a wise dosage in one evening due to the potential 5-HT2B agonistic properties.
 
How long did the initial 100 mg oral dose last?
And why is ethcathinone depicted on the labelling? Did the COA come with analytical data, and if so could you post it here (just censor the source if it's stated)?

The labelling really makes me cautios, especially since ethcathinone is widely available on the chinese market whilst para-methylmethcathinone would most likely have been custom synthesized and consecutively much more expensive.
 
N,N-Dimethyl-cathinone is floating about as well. [Metamfepramon]

still surely making para-methyl might be a custom synth but it wouldn't be a hard one ?

isn't 4-methylamphetamine neurotoxic in a similar fashion to 4-halo-amphetamines?
 
Last edited:
No, the synthesis is very easy. Para-methyl-propiophenone is even widely commercially available, only two steps from the final product. However from my experience the Chinese laboratories have a firm set of products with regular production, and straying from that path requires monetary input as it requires planning and buying other reagents etc.

I am unsure of the neurotoxicity of 4-methylamphetamine, but due to the suspiscion of 5-HT2B agonistism this is a compound that probably is best taken very seldomly. Only time will tell, I guess.
 
Winta: I do not doubt your trust to your supplier as you have spent the last two weeks campaigning the link to "his" company website whenever possible , at every drug forum available (Bluelight, Drug Forums, Hip Forums, Psychedelia.dk).

I would not have doubted the identity of said compound if it were not for the fact that the chemical structure depicted on the label and the company profile site on various chemical trade pages is N-ethyl-cathinone. Obviously someone does not have the knowledge of chemical nomenclature, wheter it be the supplier or the chinese manufacturer or both. The certificate of analysis does not say anything about what the compound actually is, without any further analytical data. And both p-methyl-methcathinone and N-ethyl-cathinone have the same molecular formula/weight.
 
You must log in or register to reply here.
Top