2-mdp

[Reminisant B]

Interesting compound, it looks like desoxypipradrol where the ring has been opened and replaced with a more traditional amphetamine.

Apparently NMDA antagonist:

2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) selectively antagonises N-methyl-aspartate (NMA).

Using electrophoretic application to rat central neurones in vivo, and bath application to frog spinal cord in vitro, 2-methyl-3,3-diphenyl-3-propanolamine was found to be a selective antagonist of N-methyl-DL-aspartate, but not of quisqualate or kainate. In this respect the (-) isomer proved to be about three times more potent than the (+) in both preparations.

PMID: 3511477

2-Methyl-3,3-diphenyl-3-propanolamine (2-MDP) produced effects in animals similar to those produced by the dissociative anesthetics such as phencyclidine (PCP). Specifically, it shared the discriminative stimulus properties of PCP in rats trained to discriminate PCP (1 mg/kg) from saline; at higher doses, it disrupted brightness discrimination and stimulated locomotor activities in rats trained to avoid shocks in an automated Y-maze; and it produced surgical anesthesia when injected IV to rhesus monkeys. These pharmacological activities were observed only with the levo-isomer of 2-MDP. The dextro-isomer was either inactive or produced opposite effects, depending on the tests. Among several related diphenylpropylamines, 2-MDP represents the optimal structure for potency of PCP-like effects since changes in the amino, 2-methyl and 3-hydroxy groups reduced the potencies of the PCP-like discriminative properties.

PMID: 6718449

Anyone think desoxypipradrol or diphenylprolinol have NMDA antagonist effects?

 

[morphiquet]

looks rather like a potent anticholinergic to me, but the unsubstituted amine seems to change this.

do you find dissociatives pleasant??

 

[Reminisant B]

No it just looks strangely similar to pipradrol (like I say with the ring open)

EDIT: Or not - sorry was incorrecting counting the carbon chain length - too long.

 

[haribo1]

Esterify the alcoohol, add some methyls onto the amine.... it's an opiate...

 

[Holy_cow]

I have personally tested 2-MDP. 3 x 25mg spaced 1 hour apart. I ended up in a half-dissociated state and with the worst drug experience I've ever had.

 

[otb01]

Holy, can you elaborate on that?

 

[Smyth]

Haribo, u should know from Janssen's original books that you cant form a reverse ester because all the steric bulk means that (a) it wont form, and (b) it readily hydrolyzes if formed under forced conditions.

The answer to you question is yes, pharmacologically im not sure what it would be like though. Remember thats an iso-propyl chain, not a straight n-propyl. It can be done though, chemically speaking. It would be called alpha-phenyl methamphetamine. Prinidol is similar to a compound called trihexyphenidyl, an anticholinergic apparently available in France.

 

[Holy_cow]

Holy, can you elaborate on that?

Don't realy know what else to say about it. That it's very long lasting maybe. PM me with any specific questions.