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2-Ethoxymethyl Salvinorin B and other Kappa opioid receptor agonists

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iceax3000

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2-Ethoxymethyl Salvinorin B or Salvinorin B Ethoxymethyl Ether

Wiki Article

Erowid Page


i have been doing some research on this chemical, that has been synthesized relatively recently. not vendors yet. has anybody had any experience with this particular Salvinorin analog? or with either the Methoxymethyl ether or herkinorin. apparently these are all extremely selective kappa opioid receptor agonist, does that necessarily mean that herkinorin is also psychoactive?
 
Herkinorin is a mu opioid agonist. I look forward to the day I can try some.
 
The potential 2 - 3 hour duration of 2-Methoxymethyl Salvinorin B sounds rrreally intimidating. However, the Erowid report makes salvinorin B ethoxymethyl ether sound intriguing. One of the four in the group apparently experienced a ++++. The talk of higher spatial perception by "Alpha" is especially fascinating to me, as the only times I've experienced it have been during combinations of salvia and DMT, the latter of which has been previously reported to cause this unique and profound effect, but here the salvinorin is producing it on its own.

I really hope the active salvinorin class is further expanded and made semi-accessible--for philosophical reasons more than anything. Imagine--no, we can't imagine, just tremble in fear and humility; there may be a monster out there lurking within grasp or one short step further into the future whose experience rivals salvinorin A's, a drug that already operates far beyond comprehension. It's hard to imagine a market for such drugs developing beyond the personal custom synth level, though.
 
i am in the small minority that truly loves the salvia experience, low dose, high dose, oral, smoked - however. i would be more than happy to test some of these salvinorin-a analogs and i hope they are made soon, as i have a feeling this pant will be scheduled very soon.
 
Me too! I actually loved salvia, til i said i would never smoke anything again. I probably will break that tho for another go at salvia.
 
oh yes you're right, herkinorin is MOA.
i really look forward to these chemicals being more widely available.

psood0nym, your post reminds me of another question: do you think it is possible to agonize the kappa opioid receptors to the point where the brain is so convinced of the imminence of death that it will release its own supply of DMT?

the strongest dose of salvinorin i have experienced was 2 tenths of a gram of 180x salvia extract... needless to say i was a much humbler person in the aftermath of the experience.
 
^I guess I'm not convinced DMT is stored up in the first place. In fact, the nature of the salvinorin A experience--as it results from consumption of a chemical entirely unrelated to DMT that nevertheless produces extraordinary and immersing experiences--seems to suggest that the speculations about DMT's connection to NDE's is even less justified, as it evinces that experiences of great intensity and totality can be produced in at least more than one way.

That's a huge dose you did. I'm sure I'd blackout long before two-tenths of a gram of 180X. However, tolerance to salvia seems to naturally vary so much that using dose weights to talk about the intensity of the experience between people the way you sort of can with other substances strikes me as extremely problematic.

Now that I think about it, Gamma's description from the Erowid report of an "Escher-like space" sounds like it's flirting with Alpha's more explicit extra-spatial experience. That's intriguing. The reportedly more visual nature of salvinorin B ethoxymethyl ether compared to salvinorin A indicated here could be useful. I've had visions but never really visuals as they're typically thought of using salvia, and those visions are more idea than visualization--like an understanding of some new life's narrative is constructed below the limen and thrust into my conscious experience with a momentum that compels visualization, as opposed, that is, to a vision whose symbolic content compels interpretive understanding. I could see how stronger visual elements might aid in my better understanding the content of the salvinorin style.
 
180x? I thought they were done like ratios, with with most being 100x and that just being pure alkaloids?
 
ah ok, sorry about that. still tho, i was always under the impression that the 20x or 40x was to do with ratios of extract added to the original leaf i think?
 
Is there anything unrelated to the salvinorins that can produce an as pronounced effect via kappa agonism?

I've gotten more psychedelia from butorphanol then I ever did from salvia, but I'm sure it was due to a combination of weak product and bad technique.
 
i was always under the impression that the 20x or 40x was to do with ratios of extract added to the original leaf i think?
Click to expand...

It implies that the product is 20 or 40 times stronger than natural leaf. For example, if the natural leaf has a concentration of 0.1% of the active chemical then a 20x extract would have 2% and the 40x extract would have 4%.
 
Interesting stuff! Though it reads that it's generally found unpleasant - like Salvia / salvinorin A.

Herkinorin is even more intriguing, how much potential does this sort of compound have as a next generation not or less tolerance inducing analgesic? The analgesic effect itself may be a big part of the addiction potential though - dunno how you feel about that?
 
-i believe the extract rating is based on the weight of foliage that goes into making one part of extract.
ex. 10g of foliage ---> 1g of extract = 10x extract

what i mean by the DMT release note is that salvia in know to induce extremely psychologically stressful trip on people, and it has be hypothesized that in scenarios where the human brain thinks that it is in mortal danger of in states of extreme stress that one of its defense mechanisms is to release endogenous DMT. anyone care t shed some light on that subject?
 
Coolio said:
Herkinorin is a mu opioid agonist. I look forward to the day I can try some.
Click to expand...


I read a study where they dosed some apes with herkinorin and they seemed to draw the conclusion that it was mostly peripherally active, though there were some central effects.

Wonder why it's mostly peripherally acting?? Everyone was so excited about this one but it may not be that great after all :\
 
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