2-desmethoxy-DOx

[atara]

This isn't a totally new idea. It's been done twice before:

MMDA-2 --> MDA
DOM --> MMA

And, since it's worked pretty well, I'm wondering about the others: MFA, from DOF, MEA, from DOET, MPA, from DOPR, and MEFA, from DOEF.

I'm a little concerned about the analogs of DOC, DOB, and DOI, as PCA/PBA/PIA were incredibly neurotoxic. Still, that doesn't mean that MCA, MBA, and MIA will be neurotoxic, but I might want to see them tested on rats first!

Anyone else think this has potential?

 

[Twigs]

I find this quite interesting as well.

How much info exists on 4-methylamphetamine neurotoxicity? Judging from this post http://www.bluelight.ru/vb/showpost.php?p=7004414&postcount=14
it doesn't exactly sound healthy, but MMA should not be neurotoxic according to Nichols, so the 3-methoxy-4-X-amphetamines could be an interesting bunch

 

[atara]

I think the one major issue is going to be the duration. MMA had the issue of lasting for a lot longer than most people would have liked, which was the main complaint.

DOEF was a lot shorter than other DOx, so MEFA is probably a good thing to look at.

 

[<pyridinyl_30>]

but MMA should not be neurotoxic according to Nichols

Are you sure you are not confusing MMA (3-methoxy-4-methylamphetamine) with MMAI (5-methoxy-6-methyl-2-aminoindan)?

 

[atara]

Are you sure you are not confusing MMA (3-methoxy-4-methylamphetamine) with MMAI (5-methoxy-6-methyl-2-aminoindan)?

I think he's sure:

http://www.ncbi.nlm.nih.gov/pubmed/1674539

 

[<pyridinyl_30>]

I think this is a great avenue to explore.

 

[Twigs]

The racemate and the enantiomers of 1-(3-methoxy-4-methyphenyl)-2- aminopropane (6) and racemic 5-methoxy-6-methyl-2-aminoindan (11) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Both 6 and 11 were found to substitute with high potency in 3,4-(methylenedioxy)methamphetamine (1) and (S)-1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (2) trained rats.
...
The results indicate that compounds 6 and 11 have animal behavioral pharmacology similar to the methylenedioxy compounds 1 and 2, but that they do not induce the serotonin neurotoxicity that has been observed for the latter two drugs.

http://www.ncbi.nlm.nih.gov/pubmed/1674539

EDIT : Damn you guys are fast