Pharmacology 2-Br-LSD

[emkee_reinvented]

About 2-Br-LSD

"A non hallucinonegenic LSD analog with therapeutic potentional for mood disorders"

https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00214-0

Nicest sounded:
•2-Br-LSD is a 5-HT2A partial agonist but lacks 5-HT2B agonism
•2-Br-LSD lacks head-twitch responses and tolerance; blocks psychedelics
•2-Br-LSD treatment promotes neuronal structural plasticity dependent on 5-HT2A
•2-Br-LSD produces active coping behavior and reverses chronic stress deficits

 

[4DQSAR]

BOL-148

A Japanese group used sodium borotritide and tetrakis(triphenylphosphine)palladium(0) to produce radio-labelled LSD. I don't think it takes a lot if imagination to recofnize that if one were to substitute sodium borotritide with the much more common sodium borohydride, the product is LSD.

Obviously overall yield was never a consideration but the work is decades old and it's more than likely that further research had improved the methodology.

The fact BOL-148 is itseld rather difficult to obtain does somewhat suggest that this methody may have been employed by one or more group who were in the business of producing acid.

 

[vecktor]

The fact BOL-148 is itseld rather difficult to obtain does somewhat suggest that this methody may have been employed by one or more group who were in the business of producing acid.

the scarcity is more likely due to the fact BOL 148 is usually made from LSD.
Bromocriptine hydrolysis can get to bromo lysergamides but it is not clean.
Nobody wants BOL 148 at the price it would cost, it was looked at for cluster headache and there was no economic case for it.

 

[4DQSAR]

I'm pretty sure BOL-148 is made from bromocryptine. After all, bromocryptine is a medicinal product that one can obtain it without that long paper-trail and need for all manner of licences.

Obtaining a licence to legally produce LSD is extremely difficult and would certainly be the more costly route.

Producing LSD from BOL-148 isn't clean - preparative chromatography is required so it's not as if it offered an advantage in that way.

BUT as I noted, the work was undertaken over two decades ago. The tritation of drugs has become a much larger field as it allows functional PET scans and other techniques to see where the drug is in real time.

 

[emkee_reinvented]

It was more the fact its presented as having the same positive effects.
As LSD and anologue s, but missing the Psychedelic effects.

The four i mentioned indicate its not a psychedelic,
does stimulate Neuroplasticity. And lacks 5-HT2B agonism.
Isn t that what causes Valvupathy, making frquent dosing dangerous.

So my aim was purely could this be a good medication ?