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2-Aminoindan - First Time - 2AI Bioassay

Limpet_Chicken

Bluelighter
Joined
Oct 13, 2005
Messages
6,322
Location
UK
I recieved my order of 1 gram of 2-aminoindan, and decided to do a quick bioassay.

Set: bedroom, with a few friends, music playing.
Mindset: in considerable pain due to unknown arm injury, unable to move arm or type without severe pain.

No medications or supplements were being taken, cigarettes were occasionally smoked, 120mg dihydrocodeine had been taken the previous night, but had worn off by the time the dose was taken.

100mg was weighed out, and split in half to give two doses of approximately 50mg, 50mg was divided into two 25mg (approximately) lines, and insufflated, one into each nostril, this was at 14.34 on 30/12/2005, the time is now 07.57 next day.

The burn produced on insufflation was intense, worse than snorting methamphetamine, Virola resin or vilca/yopo snuff, I wouln't reccomend insufflation of this compound, it literally brought tears to me eyes, streaming down my face as I gripped onto my arm-chair handles.

The pain in my arm appeared for no apparent reason after waking up two days ago, movement was severely restricted, and quite sever pain, after about 10-20 minutes post-insufflation of the dose of 2-AI, the pain had significantly decreased.

A few friends, including my girlfriend came over, we all chilled out, they were aware of the substance I was on, but were all sober, the pain had noticeably decreased by quite enough to be able to move my arm, although still quite sensitive.

Around 4-5 hours later, my friends left, leaving my and my girlfriend alone, although I was by now, again in severe pain, and feeling, paradoxically enough, very tired, but yet unable to sleep, my girlfriend then left, at around 7-8 pm, as she decided it was best I rest alone for a while.

I immediately laid down, smoked a cigarette, and attempted to go to sleep, at first, I took 2.5mg nitrazepam to help sleep, and fell into a very shallow doze, with many thoughts rapidly running through my head, I took 25mg promethazine to help actual sleep, which did nothing, but quieted the mental stream of thoughts, to my dissapointment, this lead to taking a further 50mg nitrazepam, and laying down trying to sleep.

Sleep just would not happen, 50mg of nitrazepam should by all rights, combined with the promethazine, knocked me out cold, but I am still wide awake, alert, and feel no ill effects from the substance, the pain in my arm, has now almost gone, the time now is 8.08 AM, and although not wired or jittery, I am wide awake, and very alert, sedatives or no sedatives, the 2-AI totally overpowered them.

Pulse rate is fairly rapid, breathing is regular, no jitteriness, tweaked out feelings, just relief from pain, and total alertness and a feeling of well-being, not so much euphoria, but the general feeling all isn't too bad.

I just took a further 100mg or so, in two lines, to keep away any unpleasant feelings that typically come from all-night periods of wakefulness, and as yet, have felt no ill effects.

I had read from another subject who has taken 2-aminoindan, that pain relief is roughly equipotent with morphine, although second-hand advice, I would not personally disregard it, as the subject sharing the information has quite considerable knowledge of pharmacology.

Apparently, 2-AI is synergistic with the antinocioceptive abilities of typical mu-opioid agonist painkillers, although I have yet to try the two in combination, I will, and hopefully, this will help me reduce the dosage of the painkillers I must take for a chronic knee condition.
 
Took 2-Aminoindan only once,at 50mg po,felt not much but it was clearly pushing me into a depressive sate.Never again.
 
i dont know if this is the case or not for you, but if stimulants in generally tend to push you into a depressive state, than i think it is important you mention that, so people dont just start thinking that 2-AI is crap, when really you just dont tolerance stims well. which again, i dont know is the case or not.

excellent TR chicken..ironically enough i just finished reading it on erowid..didnt know you wrote it, then came here looking for more..only to stumble onto yours again. lol.
 
Your credibility took a hard beating recently,you now seem to try to "distribute" it,but hey,its human.If more info helps,then be it:

Meth is unbeatable.
second is Methcathinon which comes close,Benzylpiperazin is fine as well,as is MDPV.2-AI is crap.No others tried.
 
Heh I have a bottle of i think ~10g of this stuff around still. I remember orally, it really barely did anything, tiny stimulant effect that lasted a real real short time for me, but that was it - but, i DO know about this pain reducing effect..

To me it felt like a non-opiate pain numbing effect, .... just.. more 'numb'. I wonder what the mechanism for this is, because I think it felt the same way as a low dose of 2C-P felt, also 2C-D did this (only two psychedelics i've noticed that did this to me), would kill a backache and kill pain better than any opiate ever did.

I've read amphetamine is equal potency as morphine for pain? Very strange, I don't notice any pain killing effects with any dose of amph. , but 2c-p, 2c-d, and 2-AI definitely! The way it feels, there's no buzz or euphoria, seems like it works by some mechanism totally different from opiates. I honestly get more of a 'buzz' from an opiate, rather than have it actually kill pain - to me its more like, a 'buzz' that makes you just not give a shit about the pain, where 2c-p/2c-d/2-ai actually did kill pain.
 
Ah yes I remember your post about painkilling,weird.From a stimulant point of view it really didn't do much.Guess I didn't search on the right angle,but then,i haven't been "on pain" to possibly notice.Maybe there's an underlying mechanism which actually had something to do with the fact that it put me on the downside mentally.Maybe some selective xy opiate binding yet to be discovered?
 
I did notice from my short affair with 2-AI (about 12 years ago) that it was a lot more pleasant when either snorted or administered rectally - orally it did nothing other than act as a 'keep you awake' drug with painkilling properties. I think I read somewhere about people comparing it with meth when IV'ed, so it might be metabolized quite quickly to a compound that keeps you awake, but with very little comparative euphoria (ephedrine is that sort of a drug with me)
 
F&B, thanks for the idea, another trip report (rectally) coming up, i'l post that as soon as I am done, its hit me pretty damn hard, far more intense feeling than I expected, definately quite active rectally.

Give me time to order a few 31 gauge spikes, and I shall grace any interested minds with an I.V report, as I think this might be quite a promising candidate, I am phobic about needles, but I think I might have to push myself in the name of science:)

I wouldn't compare it to meth, as such, the high is a lot cleaner, more focussed, the euphoria isn't quite as intense, but its still pretty strong, over all, I would compare it, when plugged as feeling closer to n-ethylamphetamine than to meth.

Fast, if you place any value on the mucous membranes lining your nose, I would NOT snort this, I have to say, from experience, that snorting 2-AI is easily as painful as having a pellet of Na metal find its way un one's nose (dodgy electrolysis setup, air got in=D)
 
My nasal admin was with a soln soaked onto cotton wool & shoved up my nose (maybe actually snorted a drug half a dozen times in the last 15 years). It's because I've got sinuses that get inflammed very easily, so the only way my nose gets used to absorb drugs these days is like I've outlined above; even then, it's an option of last choice most of the time.

I've made a comment about rapid achievement of peak plasma levels in the other 2-AI thread of yours
 
Now wait a minute,about this painkilling effect-theres a drug called Bicifadine which is a tolyl-azabicyclohexane,also has the phenethylamine skeleton.It acts via ser/nor/some dopamin uptake inhibition plus a NMDA pathway-now I see many similarities to 2-Aminoindan.Could be an important finding yaesutom.
 
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