2,5-dimethoxy-4-ethoxy[phenethylamine/amphetamine] information ?

[Zirkon]

Hello bluelight !

I've seen MEM entry in PiHKAL (2,5-dimethoxy-4-ethoxyamphetamine) and I was wondering if the phenethylamine counterpart of this has been studied or bioassayed by somebody who eventually could provide more information about it.

Thanks, and have a good day

 

[Morninggloryseed]

Hello bluelight !

I've seen MEM entry in PiHKAL (2,5-dimethoxy-4-ethoxyamphetamine) and I was wondering if the phenethylamine counterpart of this has been studied or bioassayed by somebody who eventually could provide more information about it.

Thanks, and have a good day

Welcome to BL.. the '2C' would be 2C-O-2 and myself and the other 2C lovers used to debate about this and 2C-O-4 and others back in the day. Common consensus is, it will be inactive but I don't believe anyone really knows. My knowledge of steric hindrance and all of those things that relate to the shape of a psychedelic, and it's activity (or lack there of) is lacking so someone else will have to get you the details....but yeah we used to speculate on this back in the day and it is considered a dead end.

 

[Zirkon]

Thanks morninggloryseed !

Damn, that was too good to be true :/

 

[Morninggloryseed]

I forget what an amazing chemical MEM sounds like.

MEM is a 'DOx' drug I'd love to get my hands on. I like to say my days with DOx are over but that one, and TMA-2 are two definitely worth giving a spin I feel.

 

[Xorkoth]

I should look up MEM, never heard of it.

 

[ebola?]

Sounds like a more potent, more stimulating incarnation of escaline.

ebola

 

[sekio]

The 2C-O series may not bode well for neurotoxicity.

The simple compound that results from the stripping of all three of the O-methyl groups from TMPEA is the extremely potent neurotoxin, 6-hydroxydopamine. When it is ad-ministered to an otherwise intact experimental animal, it produces sympathectomy, effectively destroying the sympathetic nervous system. And some of the methyl groups of TMPEA are known to be stripped off through the normal metabolic processes that occur in the liver. There are many fascinating psychedelics that have a signature of methoxyl groups para to one-another. It is known that they, too, can lose a methyl group or two. It would be intriguing to see if there was some biochemical overlap between the metabolism of some of these centrally active drugs and the metabolic fate of 6-hydroxydopamine. But in a test animal, of course, rather than in man.

http://www.erowid.org/library/books_online/pihkal/pihkal168.shtml

From my cursory inspection, the known 2c-O compounds (2c-O, 2c-O-4) are less potent and more side effects prone than mescaline (when they have activity at all).

I think 2C-O-2 and 2C-O-7 should be made and tasted anyway, just to be sure.

 

[Morninggloryseed]

I should look up MEM, never heard of it.

MEM was like the forgotten child of Shulgin's. MEM and TMA-2 were the first RCs of Shulgins along with DOM.

The 2C-O series may not bode well for neurotoxicity.


http://www.erowid.org/library/books_online/pihkal/pihkal168.shtml

From my cursory inspection, the known 2c-O compounds (2c-O, 2c-O-4) are less potent and more side effects prone than mescaline (when they have activity at all).

I think 2C-O-2 and 2C-O-7 should be made and tasted anyway, just to be sure.

I know there are posts here from 2004, 2005 or so where I am speculating with F&B and others about these compounds..I was convinced that 2C-O-2 and 2C-O-7 had to be some undiscovered gems and the other, smarter BLers did a good job of convincing me I was wrong and they are not gonna be active. Maybe I'll try to UTFSE and see what I can find.