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2, 4, 5 vs. 2, 4, 6

any major dude

any major dude

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I know this substitution pattern has been explored with DOM, but I'm unaware of any other known psychedelic that has had this analogue explored. It seems to reduce potency and duration. Both of which could be advantageous, especially with the DOx compounds. Also, with the 2c-x's the potency reduction wouldn't really be necessary, but for therapeutic use, a cut in duration could be seen as a benefit. Has anyone experimented with the 2,4,6 counterpart of anything like the 2c's or even any of the other DOx's?
 
any major dude said:
I know this substitution pattern has been explored with DOM, but I'm unaware of any other known psychedelic that has had this analogue explored. It seems to reduce potency and duration. Both of which could be advantageous, especially with the DOx compounds. Also, with the 2c-x's the potency reduction wouldn't really be necessary, but for therapeutic use, a cut in duration could be seen as a benefit. Has anyone experimented with the 2,4,6 counterpart of anything like the 2c's or even any of the other DOx's?
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see pihkal, they are known as the 'pseudo' compounds I think DOB has had the pseudo made and I think one of the CT series. then of course there is TMA-6
 
The interest to all sorts of weird chemicals here is quite amusing.

TMA-2 and TMA-6 are very alike, I don't think I will be able to distinguish one of them from another in a double blind test, though at the times I've been exploring the sixth I thought I could. The sixth is maybe a little more euphoric but also has a little more of all kinds of intestine side effects. While the second is maybe a little more hallucinogenic, and the muscle tensions it produces are maybe a little more prominent.

Some of the pseudo amphetamines should be quite potent MAOI, especially the ones bearing sulphur and oxygen substituents at the 4th position.
 
see pihkal, they are known as the 'pseudo' compounds I think DOB has had the pseudo made and I think one of the CT series. then of course there is TMA-6
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Thats where I started... Of the pseudo or psi compounds he only mentions the fact they would likely be active, interesting, and potentially more difficult to synthesize. The Ψ 2c-t-4 entry is terribly sparse, and TMA-6 doesn't appear to lose potency or duration like its dimethoxy cousins.
 
^ that's really strange, because I remember for some entry he talked about how the 2,4,6 was almost as "magic" as the 2,4,5 substitution pattern. He seemed to be really interested in it, but maybe he just got caught up with other things?
 
The problem is the difficulty in making them. The only things that prefer to substitute in this way are groups with lone-pair electrons not present, eg NO2 (excluding things like methoxy and also alkyl groups).
 
Sturnam said:
^ that's really strange, because I remember for some entry he talked about how the 2,4,6 was almost as "magic" as the 2,4,5 substitution pattern. He seemed to be really interested in it, but maybe he just got caught up with other things?
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If i remember correctly that was in reference to TMA-2 & 6.

The difficulty in synthesis does seem to be quite the barrier though. I'd really like to see a Ψ2C-G series, as the 2C-G series has interested me for a while, but the +20-40hr durations are a bit of a turnoff...
 
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Hell, what about the meta's (3,4,5- I believe)?
Ive been very interested in these guys as this is the mescaline pattern if Im not mistaken.
 
Desoxymescaline (4-methyl-3,5-dimethoxy-PEA) is active at 40-120mg according to pih. You could see it as the 3,4,5-analogue of 2C-D... so maybe you could make those from other 2c:s and expect activity. Halogens, ethyl, propyl, all those would be interesting...
 
I will make a mention that the production of 4-alkylated psi-phenethylamines is in theory not a difficult procedure (but I don't want to mention anything related to synthesis)... In fact I'm surprised no one has made many of them yet, but it's probably due to the fact that they're not really mentioned in PiHKAL.
 
just a report for what it's worth in contrast to the above statement of similarity, I like many of the 2C series, excluding 2CI, but found TMA-6 to be absolute garbage. @ 50mg I mostly felt sick and shitty with next to zero useful entheogenic effects. My ladyfriend had the same experience. Perhaps a shitty synthesis/impure material?
I have 50mg of TMA-2 ready to go for almost a year now but haven't found the 12 hours to invest in it with due scientific observation and controls, but I thoroughly believe it will be a much better compound than TMA-6. YMMV.
 
This is not an uncommon reaction to TMAs. Impurities may alter their effects, but not to great extent, as far as I am aware.
 
I was highly disappointed in TMA-6, and TMA-2 was only slightly better. A friend of mine who tried TMA-1 described the first 4 hours as Heaven and the last 8 as Hell.

As for 3,5-dimethoxy-4-methylphenethanamine, Sasha Shulgin claims it was inactive at up to around 40 mg while Ann Shulgin had a weeklong ++++ that involved coming into contact with the Atman.

4-bromo-3,5-dimethoxyphenethanamine was "definitely not a placebo" at only a couple of milligrams, but it was apparently not taken higher.

My favorite substitution patterns are the 3,4, the 3,4,5, and the 3 [this last one is not even really explored in PiHKAL]. 2,4,5's and 2,4,6's are just OK imo.
 
Rectify said:
I was highly disappointed in TMA-6, and TMA-2 was only slightly better. A friend of mine who tried TMA-1 described the first 4 hours as Heaven and the last 8 as Hell.

As for 3,5-dimethoxy-4-methylphenethanamine, Sasha Shulgin claims it was inactive at up to around 40 mg while Ann Shulgin had a weeklong ++++ that involved coming into contact with the Atman.

4-bromo-3,5-dimethoxyphenethanamine was "definitely not a placebo" at only a couple of milligrams, but it was apparently not taken higher.

My favorite substitution patterns are the 3,4, the 3,4,5, and the 3 [this last one is not even really explored in PiHKAL]. 2,4,5's and 2,4,6's are just OK imo.
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Really interested in this post. Do you have any further place I can read about these (desoxy, bromoscaline)? Or even if you could elaborate on what 3 substituted phens you've tried, etc. Thanks!
 
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