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2,3 MDMA and 2,3 MDA???

psilocybinsane

psilocybinsane

Bluelighter
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Nov 29, 2010
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Ok, first of all, I hope this is the right place to post this, I'm not even sure if these compounds are empathogens or not but if this isn't the right place then moderators do your thing :) I used the search engine here and tried googling them but I can not find anything useful... They are listed as for sale on a common vendor site, 2,3 mdma and 2,3 mda. Anyone know ANYTHING about these two compounds? I'm very curious...
 
One of them--and I forget which--is in PiHKAL: Phenylethylamines I Have Known and Loved by Alexander and Ann Shulgin. The trip report goes something like: "Doesn't really feel like an empathogen, yet I was up all night cleaning the house, so maybe something going on there."
 
I didn't even think of PiHKAL, when I google searched them and only found another vendor, not any information, I had assumed I had stumbled upon something new. Still, anyone have any more info to add?
 
Just google this:
2 3-methylenedioxymethamphetamine

there are a ton of articles and whatnot... Do the same trick for mda, use the iupac name in the search bar
 
2,3 mda has a Wikipedia entry witch its counterpart so to speak does not. The article states that it it's a stimulant with little entactogenic effects. So I'm going to assume that 2,3 mdma is a stim as well. So I have zero knowledge of molecules, can someone enlighten me as to what the 2,3 and 3,4 prefixes are, and how they change the way the molecule works in the human body? I know it's off topic but while we're slightly on the subject I would like to get a better understanding of the relation of molecular makeup to pharmacology, any help would be greatly appreciated :)
 
psilocybinsane said:
So what this article: http://www.ncbi.nlm.nih.gov/pmc/art...www.ncbi.nlm.nih.gov/pmc/articles/PMC2095113/ is saying is that 2,3 mdma has a low affinity for 5ht transporters and a higher affinity for NET transporters. This would mean that it as a compound is a stimulant rather than an empathogen correct?
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not necessarily. mdma itself has a surprisingly low affinity for the 5-ht-transporter. the 5-ht2b receptor seems to be the main thing with serotonin release.
but low affinity for the 5-ht transporter and high affinity for NET fits nicely to the (not very reliable, second hand) report in pihkal.

2,3 mda has a Wikipedia entry witch its counterpart so to speak does not. The article states that it it's a stimulant with little entactogenic effects. So I'm going to assume that 2,3 mdma is a stim as well. So I have zero knowledge of molecules, can someone enlighten me as to what the 2,3 and 3,4 prefixes are, and how they change the way the molecule works in the human body? I know it's off topic but while we're slightly on the subject I would like to get a better understanding of the relation of molecular makeup to pharmacology, any help would be greatly appreciated
Click to expand...

the numbers give you the position of the methylenedioxy bridge on the ring. with "2,3" the methylenedioxy group would be shifted one position towards the side chain. how that changes how the molecule works is unknown as long as it's not tested against a whole battery of receptors and preferably in vivo.
 
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The Wikipedia article didn't say anything about 5ht2b affinity, but seeing as how the article only references the PiHKAL entry for the normal 3,4 mda (and in this PiHKAL entry, the 2,3 version only has a couple sentences about it, stating that someone found it to be stimulating), I'm not even sure where the hell most of the articles info originated from. But like everything on Wikipedia, l take it with SEVERAL grains of salt...

Now... Has anyone here actually ingested either of said compounds? I'm assuming not or they probably would have chimed in already. Anyone willing, for harm reductions sake (or plain curiosity), to order one of these compounds for sampling purposes? Yeah they could just be your average stim, but who knows? They may be slight empathogens, or they could have less side effects than common stims, or they could be total crap :) if I had the extra money I would try them myself, but alas, I'm unemployed :/

Sorry to ramble so long, I've had my fair share of stims today as well. Last but not least, I don't really get what you're trying to say about the molecule Black, but I do want to learn more on the subject. Could you or anyone else point me in the direction of some threads/sites where I could learn the basics about molecules? Thank you so much guys :D
 
No, we haven't tried it. Would you like to volunteer, be our guinea pig, and report back?

2,3-MD(M)A and 3,4-MD(M)A are shaped differently on the molecular level. If you really want to understand what they actually look like, you're going to need to go to college and take Organic Chemistry, which is second year chemistry. You have to take Intro to Chemistry for two semesters first. Organic chemistry takes a while to learn, unless you are just naturally gifted. I wasn't, but I managed to learn O-Chem; it just took me a while.
 
I am totally broke or else I would be placing an order right now out of curiosity... I would LOVE to take chemistry, but if I were to go to college, I would probably be focusing on furthering my learning of computers and networks.

So, there's really no one here that has tried either of these?

And if not, is anyone willing to order one and report back? I don't want to beg, but I'm dying to hear a first hand report...

Anybody?
 
It's hard to convince people to buy or try a new research chemical that they know nothing about.
 
I just saw this come up somewhere I'm familiar with and noticed this article during my search. Do any of those more experienced than I see any glaring indication that the potential for toxicity would be higher than regular old 3,4-MDMA? If not, I would be willing to obtain after my next check and report back.
 
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