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(-)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane

egor

egor

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Anyone know of any animal toxicity studies, dose-response curve, or anything else helpful on this one???? I have a feeling we are going to start seeing a lot more questions about this in the not so distant future;) Supposedly 3-10 times more potent than cocaine by weight, so caution is neccessary. Any info would be greatly appreciated
 
Personally, I think b-CPT would be more enjoyable. Really potent cocaine analogues seem really dangerous considering the sort of compulsive use it generates.
 
At least it lasts longer than cocaine due to the lack of the easily hydrolyzable ester link between the benzene ring and the tropane ring, and it lacks the anaesthetic action of cocaine so it should be less cardiotoxic as well...
I really want to try this stuff.
(On a side note, I also really want to know what happens if you replace that F with a trifluoromethyl... CIT, the iodo analog is active, and the size of the CF3 group is slightly less than of a I atom, but more electronegative sooo... :))
 
Actually the CF3 analogue has been made and tested (compound 11m in Singh's paper) and is only slightly more potent than CPT or CFT, but less potent than CIT.

I've been wanting to try CFT for years, ever since I had to do an essay on the dopamine reuptake transporter back in 2nd year of my undergrad degree....actually though I suspect CPT might be the most abusable, purely because anything with a halogen will taste like crap if you smoke it.

Be interesting to see what comes of these compounds, I can't believe none of the RC companies have discovered them yet, maybe the precursors are just too hard to get.
 
I never even considered smoking them, but yeah, the halos will taste like ass. I don't think there's a big enough market for "legal coke" when there's so much cocaine.

A cocaine that lasted for 3 hours would be pretty nice, imho.
 
Well, where I live there isn't much coke, and what coke there is is usually of low quality.
I haven't even managed to run into any myself. Admittedly I haven't been actively seeking it out, but it is telling that I haven't encountered any simply through dealings (no, not of the selling kind, the interacting kind) with other people.
So anyway I guess my point is that if some CFT were to make it here it would be truly excellent :p .

Ah, I wasn't aware of that m_s_ , thanks for the info :) . Disappointing it's not heaps more active like i'd imagined, but, oh well.

The reason this stuff isn't being produced more than it is is a matter of precursors. A effective route to the starting precursors (namely, a carboxylic acid) needs to be developed.
 
MattPsy said:
Well, where I live there isn't much coke, and what coke there is is usually of low quality.
I haven't even managed to run into any myself. Admittedly I haven't been actively seeking it out, but it is telling that I haven't encountered any simply through dealings (no, not of the selling kind, the interacting kind) with other people.
So anyway I guess my point is that if some CFT were to make it here it would be truly excellent :p .

Ah, I wasn't aware of that m_s_ , thanks for the info :) . Disappointing it's not heaps more active like i'd imagined, but, oh well.

The reason this stuff isn't being produced more than it is is a matter of precursors. A effective route to the starting precursors (namely, a carboxylic acid) needs to be developed.
Click to expand...

if you look at the other thread about tesofensine, you might notice a certain structural similarity which might eventually lead to the common precursor (anhydro...) becoming commercially available :) heres hoping.

I too have heard b-CFT isn't all its cracked up to be :)
v
 
This stuff would be made illegal in a heartbeat. It's probably expensive to make and would be bonkers expensive in the uderground market, which is you probably will never see it from a company. This is one you'll have to either know or be a chemist to ever try I think.
 
I've read that replacing the methyl ester with an isopropyl ester makes the product longer lasting...
 
What was the route of administration for the 4mg? Nasal, just like coke? I really don't like the idea of cocaine or its analogues (pure DA reuptake inhibitors would just attenuate the effects of my much-enjoyed amphetamines and aren't really a good substitute for the amphetamines unless they have very protracted half-lives), but I've always wondered what the human dose-equivalence for coke::CFT was. In studies of rats using either IV admin or in vivo microdialysis, CFT has ranged from 10x-60x as potent as cocaine as a psychostimulant and a behavioral reinforcer.
 
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I've heard that the p-F benzyl ester of w-trophine is good. Only 40% as strong as 'the real thing' but with only one ester, it's longer acting...
 
haribo1 said:
I've heard that the p-F benzyl ester of w-trophine is good. Only 40% as strong as 'the real thing' but with only one ester, it's longer acting...
Click to expand...

somewhere I have seen a paper on the sodium? channel blocking effects of tropacocaine, I cannot find it now, but it would be interesting to see if tropacocaine had more or less channel blocking effects than cocaine. these would probably reveal itself in reports of effectiveness as a local anaesthetic. tropacocaine had limited use as a local anesthetic... if it had equal or greater channel blocking effects to cocaine I would recommend caution, as twice to 10 times the dose of p-fluoro tropacocaine vs cocaine is going to have consumed to get the stimulatory effects. I can see the ol ticker struggling.
if the same SAR applies as to the WIN phenyltropanes then the para chloro and para iodo along with the softer methyl are going to be more active than plain tropacocaine too.
haribo...are you back in blighty or still in the US?
V
 
haribo1 said:
I've heard that the p-F benzyl ester of w-trophine is good. Only 40% as strong as 'the real thing' but with only one ester, it's longer acting...
Click to expand...


Having tried some (pseudotropyl 4-fluorobenzoate) recently, I think the quoted 40% the activity of cocaine is a bit high - I'd say 25-30 % is possibly closer to the truth
 
What's pseudotropyl 4-fluorobenzoate like. How long does it act, what's the kick like?
 
^ was that oral of insufflated?

can anyway diagram pseudotropyl benzoate and/or the flourinated derivative...and if possible throw cocaine in there as well :)

TIA
 
^ It's the same configuration as cocaine, except the COOMe group is replaced with a plain hydrogen and the benzoic acid has a fluoro group at the opposite end of the ring from the carboxylic group.

In an effort to be lazy I've probably expended more effort than just drawing the damn thing! =D
 
^ and on the flip side of that poinjt above Cocaethylene is i believe more potent and of greater duration perhaps du to enhanced lipophilicity

(??)
 
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