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1-Methyl-Psilocin

Doctor Abalaba said:
I really don't want to attack you personally by attacking your theory, I just dont see how you're making this leap. Are you only using Tihkal as background, or do you have another source (perhaps experiential)?
Click to expand...

It's simply based on theory and the 5HT selectiveness of the 2-Alkylated Ts; we won't know until someone tastes more of the 2-substituted tryptamines. The only strange thing is the lack of efficacy of Indapex. Perhaps 5HT6 has nothing to do with it, and it's actually another subtype that yields such an effect, or no subtype at all but something totally unconsidered.

They're not difficult to make, but no one with the ability seems to have taken it upon themselves to try them out. Certainly the potency decrease in TiHKAL didn't look promising to Shulgin.
 
5HT2c agonists...ew...nasty.

They are used as a model drug for inducing panic attacks in rat studies to test anti-anxiety drugs.

The piperazines used as 'recreational' drugs have a lot of 5HT2c involvement, and everybody knows how vile they are as a general class.
I think, that the 5HT2c affinity is the main reason why they are so awful.
 
^Yeah, I wish it was easy to get one's hands on a selective 5HT2c antagonist on the cheap. Hell, maybe it is and I'm just ignorant. I'd love to co-administer the full spectrum psychedelics (psilocin, LSD, 2C-E, DPT) with varying doses of such an antagonist -- esp. DPT, as I've heard it has an affinity for 5HT1a proportional to 5HT2a only rivaled by 5-MeO-DMT among widely available psychedelics (I consider these two the most directly ego dissolving psychedelics in their effect relative to other psychedelic effects -- visuals, enhancement of holistic thought, etc.), and so I'm interested in the possible role of 5HT1a/5HT2a proportionality in ego dissolution (particularly if one could remove some of the anxiety that comes with ego dissolution using a selective 5HT2c antagonist). Granted, I'm naive as all hell in these more technical matters.

According to ebola's remark in the thread linked to below the effects of the NBOMe's, or at least 25I, may provide some insight as to what co-administration of the antagonist with most psychedelics would be like (though if I recall correctly skillet's recent comment in the 25C-NBOMe thread stated 25I's selectivity over 2a is "only" about 10x).

http://www.bluelight.ru/vb/showthread.php?p=8602476
 
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