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1-Methyl-Psilocin

Jabberwocky

Jabberwocky

Frumious Bandersnatch
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There's a SAR for 1-methyl-psilocin that posits functional affinity for 5HT2C over 5HT2A. Psilocin itself is a mixed agonist at ht2a/c. If you're interested in this study search google for 1-methyl-psilocin and you can download it from a UK drug forum.

Agonism at 5HT2A is somehow linked to inhibitory signals to the visual cortex (edge detection, depth perception, etc). This accounts for the visuals experienced under psilocin intoxication.

If 1-methyl-psilocin does not target 5HT2A, would it then not cause visuals of the nature experienced on psilocin? What would the subjective quality of 1-methyl-psilocin be like (or in other words, what would agonism at HT2C be like)?

Does 1-methyl-psilocin have greater advantage over psilocin for use in treatment of headaches, OCD, etc (due to not mediating visual effects)?

I'm interested in these questions...maybe someone can methylate some psilocin and find out what this drug is like?
 
Yes, I think so at least. It would be adding the methyl group to the nitrogen. It is also referred to somewhere as n-methyl-psilocin.

I don't know if its been tested in humans....Sandoz has synthesized it and run some tests on it, but I cannot find that information.

Generally, if anyone wants to speculate what a 5HT2C psychedelic would be like, go ahead! :)
 
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Hey!

I have tried 1-Me-5-meo-dipt and it has subtle like effects alone BUT..

when you mix it with 5-meo-dipt you get an intense trip free of many of the negative side effects from 5meo-dipt.... and different/better trip..

But mixing 1-Me-foxy with anything else besides foxy (DPT etc) it doesn't have that special synergy.
 
^ This makes some sense maybe...the pharmacology of 5-MeO-T is quite different from 4-ho'Ts, and if 1-methylation puts some selectivity on receptor affinity for the 4-ho-dmt (selective affinity to 5HT2C over A), then it very well could change around the affinity of 5-meo-Ts, maybe having less affinity for the (correct me if I'm wrong) 5HT3 receptors (GI distress receptors!).
 
1-Methylpsilocin

3-[2-(Dimethylamino)ethyl]-1-methylindol-4-ol (C13 H18 N2O)

Anyone familiar with the pharmacology of this substance? Is it psychoactive, and if so, dosage?

I'm aware it is a 5HT 2c agonist that appears to have some capacity in reducing obsessive/compulsive behaviors, but other than that i've got no idea.
 
My guess is: Very much down in potency, 5HT6 ligand, probable audio distortion agent.
 
i thought the methylation would most likely cause a drop in potency. Why do you think it would cause audio distortion?

[EDIT] If any mods would like to merge this and the other 1-Methylpsilocin thread linked above, that would probably help other people with similar questions. Thanks!
 
The 1-alkyl trypamines have generally been reported as causing auditory distortion.
 
Tsssssk, you're correct! The one position is on the indolic amine. In this case I suspect it will just be down in potency a lot.
 
that could potentially make it a good candidate for ocd studies... I've never come across, even in reading, any other 1 alkyl trypt's, have many been studied or bioassayed?

What receptors to the 2 sub trypt's have the highest affinity for?
 
There's a suspicious looking wikipedia entry on 1-methyl-5-methoxy-diisopropyltryptamine.

The 2-substituted receptors tend to have an affinity for 5HT6 (among other serotonergic receptors).
 
nuke said:
There's a suspicious looking wikipedia entry on 1-methyl-5-methoxy-diisopropyltryptamine.

The 2-substituted receptors tend to have an affinity for 5HT6 (among other serotonergic receptors).
Click to expand...

What a bizarre wikipedia entry. I think it's a fake :\ Maybe some vendor trying to hype ?
 
Well if you use the potency of 1-methyl LSD to LSD, then apply that to psilocin (I know it doesn't work like this, it's just for the sake of simplicity), you end up with something requiring 30mg+ for a significant effect.

A much better proposition is 1-acetylation: I know that 1-acetyl LSD (ALD-52) isn't wonderfully stable and hydrolyses at the mere sight of water, but I know nothing about the stability of 1-acetyltryptamines. They may be a fair bit more stable than ALD-52 (couldn't be much less stable! =D) - if so they'd be interesting to try (& legal in the UK ;) )
 
nuke said:
The 1-alkyl trypamines have generally been reported as causing auditory distortion.
Click to expand...

I really enjoying pondering how the auditory distortions occur. The distortions are very unique. They target at pitch perception. Furthermore, it doesn't seem to apply some additive or multipicative function to the distortions. To put it simply, there doesn't seem to be a relationship between the presented stimuli and its perception in vivo.
But I simply can not accept that 2-alkyl is the key.
First of all, all I know of is tihkal as a source of info on compounds like 2-Me-DMT. Shulgin was pretty vague in that entry. It can't qualify as serious evidence.
I really don't want to attack you personally by attacking your theory, I just dont see how you're making this leap. Are you only using Tihkal as background, or do you have another source (perhaps experiential)?
 
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