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RCs 1-Aminomethyl-5-methoxyindane (AMMI?)

V

_VR

Greenlighter
Joined
Dec 23, 2011
Messages
8
Hello all,

Greenlighter here, 2nd post. I have read the OD Posting Standards and UTFSE but apologize in advance if my new thread here is in error. I find that although I've read many, many threads on BL over the years, I've just had no mind to pay much attention to *where* those threads were posted or by whom. I will stay within guidelines as I understand them and gratefully accept a moderator's decision to move or amend my post.

That said... I've sat on this topic for a few days, and UTFSE during, to see if there would be any mention of this molecule. Aside from a mention in the "I like to draw random molecules" thread, I could find no mention of it. Though with only a rudimentary understanding of organic chemistry, it is quite possible - probable even - that if I knew other more likely ways to name this compound, I'd have had more search results.

The reason for waiting to post is that I originally learned of this substance's appearance on the RC market via an email from a vendor. I had previously seen this same vendor announce the forthcoming arrival of the chemical, but with a branded name and no indication of its contents. The current situation is apparently that several kilograms of the product have been synthesized and is being sold in powder form and that "pellets" will be pressed in the following weeks. Being that so little data is out there, and that afaict there is but one vendor, well you can understand my hesitance to post. BUT...

With it purportedly being researched by Nichols et al, but I not having access to appropriate journals.. I thought a post looking for more information on this chemical was in order, especially since it is absolutely being solicited on the RC market.

Thanks,

_VR
 
iv just got an email of one of the uk vendors saying its a mdma derivative , and if its the same as iv been reading about in other sites its a lot closer to the real thing than most of what we have been getting passed of with of late
 
This is basically N-methyl-5-methoxy-aminoindane, compare 5-iodo-aminoindane which sucked shit, and MMAI, N-methyl-aminoindane. Dunno much about the latter, though I'd wager the desmethyl compounds are nicer. (see: MMAI vs MDAI)

http://en.wikipedia.org/wiki/1-Aminomethyl-5-methoxyindane This is a totally new serotonin releaser, to the best of my knowledge. No idea on dose or potency though, wiki says "similar to difluoro-MDA".
 
I did find it mentioned in one of the referenced wikipedia articles ("comparative molecular field analysis..." I was unable to retrieve the full text of the other journal entry.

"The hSERT A169D mutant showed a significant increase in potency for ten amphetamines (DFA, MDMA, DiFMDA, 2MeMDA, 4-TFMA, AMMT, AMMI, DCPP, MM(R)NMA, and N-dipropylindan (Table 2). The selectivity field CoMFA for the A169D mutant, however, showed no predominating fields, indicating that the increase in potency of the amphetamine analogs is probably not a direct result of hydrogen bonding or steric interactions, but rather may result from a global structural change in the SERT protein"

From what little information I was able to gather, 100 mg is a suggested active "dose", but that information is only as accurate as emails from strangers can be considered.

I will post some reagent results likely within a week.
 
Ok, I found the other Nichols article ("distinct molecular recognition...")

"For the substituted amphetamines, the order of increasing Ki values at hSERT was DCA < 4-MTA < 2-Me-MDA < MMAI < MDA <3-MTA < AMMI < DFA <6-Me-MDA <4-TFMA < AMMT. The order of increasing Ki values for the substituted amphetamines at dSERT was DCA < 4-MTA < 3-MTA < AMMT < MMAI < MDA <6-Me-MDA < 2-Me-MDA < DFA < 4-TFMA. The order of increasing Ki values for H1–281D282–476H477–638 chimera was DCA < 4-MTA < 3-MTA = MDA = 6-Me-MDA < AMMT = AMMI < MMAI = 2-Me-MDA < 4-TFMA."

*edit - I can only assume that what, above, appears like a heart emoticon on my screen does so on yours as well. That should, of course, be read as "less than three."
 
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Doesn't sound like AMMI either, except perhaps in overdose (serotonin syndrome). It sounds exactly like the a chemical a vedor was selling not too long ago as MDMAI, which felt nothing like an MDAI. It definately felt serotonergic though, but in all doses felt horribly toxic... and the taste remineded me of piperazines. The fact that this "AMMI" and the "MDMAI" had psychedelic effects suggests direct serotonergic agonism, as did the bodyload. These SSRA's shouldn't have any significant 5-HT2A agonism, if they did I'm sure it would be reported in the literature (head-shaking mice etc.).

I'm hoping IAP becomes available soon as I miss MDAI. The MDAI drought is also an opportunity for unscrupulous vendors to rid themselves of random chemicals to fill the void, as we are seeing here.
 
I got some supposed AMMI for reagent testing, however as I can see there are at least 3 different coloured chemicals in the bag I'm not going to waste bottled reagent on it, I don't think it's even worth wasting ampoule based reagent on it either. One is a tanish powder, the other is dark green crystals, the other is white lumps.

changed my mind as I found a couple of those MCPP ampoule ones knocking about and it reacted to brown as 6-apb that I once tested with one of them did. so I suspect the tannish powder might be 6-apb.

edit: correction while disposing of it a third white lumpy chemical became apparent.
 
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