1-(4-methylphenyl)-2-aminobutane

[Metcalf]

Does anyone have any information about this chemical?

It was claimed to me that it has MDMA-like pharmacology, but I can't find one shred of information on it anywhere.

 

[MurphyClox]

Neurotoxicity might be a concern though.

Seconded!
para-Methyl is not a good idea, similarity to p-Me-amphetamine (a proven neurotoxin due to effective and prolonged 5HT-depletion) is alarmingly high.

Looks like the next mephedrone-style-disaster

- Murphy

 

[Metcalf]

Looks like the next mephedrone-style-disaster

Yeah, that's what I figured when I saw the para-methyl group. Thankfully no one is offering this or has plans to that I'm aware of.

It could be interesting nonetheless. I just wish there was more information about it.

 

[ebola?]

I would say, "maybe".
Given that we're working with non-bk substituted phenethylamine SAR, we might expect to see reduction in (maybe abolition of) dopaminergic activity, a la aephetamine or MBDB, leading to reduced or abolished neurotoxicity...or not (I'm not gonna try it till there's SOME data).

ebola

 

[hamhurricane]

sounds interesting to me. i always loved reading the reports of BDB, a real oddball that one was. probs highly serotonergic as both alpha-ethylation and para-methylation infer serotonergic effects on PEAs...well alpha-ethylation is a little unclear, aemphetamine and methaemphetamine have been synthed and bioassayed but not formally studied for binding affinities to my knowledge so im really extrapolating from MBDB and BDB.

 

[ebola?]

iirc, aephetamine has indeed been synthesized and evaluated, ending up highly specific for NE. What would "aemphetamine" be?

ebola

 

[Metcalf]

I'm starting to come around to the idea of this one. The para-methyl would likely lead to efficient serotonin release. The alpha-ethyl should reduce DA release and increase NE release relative to amphetamine and therefore reduce neurotoxicity relative to p-methylamphetamine.

I think there is a possibility that this could hit the sweet spot.

 

[GZero]

This is very interesting.

 

[ebola?]

As for the neurotoxicity it's pretty much fully dependent on the ratio of serotonin versus dopamine release.

I don't think that this is accurate. Bracketing aside issues with the notion of something exhibiting a characteristic "pretty much fully" (), some entactogens form specifically toxic metabolites (I'm thinking of MDMA and MDA). Also, I don't think that the unique toxicity of para-[non-fluorine halogen]-amphetamines relates to their ratio of DA and 5ht release.

Also unlike the cathinones it's likely to be a full-fledged releasing agent and not a shitty half and half reuptake inhibitor.

Does this characterize the series? I believe methylone to rather clearly act overwhelmingly as a releaser. Also, I've heard this same line of reasoning used to explain why fencamfamine is so good.

ebola

 

[hamhurricane]

iirc, aephetamine has indeed been synthesized and evaluated, ending up highly specific for NE. What would "aemphetamine" be?

whoops we are talking about the same chemical i just misspelled it, do you have the ref for the journal where it was found to be selective for NE?

some entactogens form specifically toxic metabolites (I'm thinking of MDMA and MDA). Also, I don't think that the unique toxicity of para-[non-fluorine halogen]-amphetamines relates to their ratio of DA and 5ht release.

yes i agree completely. RZ suggested that the toxicity of the p-halo-PEAs stems from a toxic metabolite/conjugate in the two position if i remember correctly, and the mechanism is not shared by cathinones. i have always been worried about anything with a MD ring and the subsequent dihydroxy tertiary and quaternary pro-oxidant metabolites, another reason to stay away from MDPV if you ask me - even if its a DARI.

Does this characterize the series? I believe methylone to rather clearly act overwhelmingly as a releaser. Also, I've heard this same line of reasoning used to explain why fencamfamine is so good.

methylone is a strong releaser but much less effective than MDMA the beta-keto makes it primarily a DARI

 

[negrogesic]

What looks good on paper doesnt always pan out...

Not saying that this doesn't have potential, but ive yet to seen a true MDMA like drug surface (close, but still, missing something)..........

 

[ebola?]

whoops we are talking about the same chemical i just misspelled it, do you have the ref for the journal where it was found to be selective for NE?

Hey. There was a gross delay in response because I don't have too much to add. I was recalling some speculation on here, and someone threw up references, I believe.

i have always been worried about anything with a MD ring and the subsequent dihydroxy tertiary and quaternary pro-oxidant metabolites, another reason to stay away from MDPV if you ask me - even if its a DARI.

This is interesting, given others' endorsement of its safety. Could it be that for such toxic metabolites to do real damage, they'd need be taken up by a monoaminergic transporter, and it's only really under conditions of serotonin depletion that this will happen, SERT taking up dopamine-like compounds?

methylone is a strong releaser but much less effective than MDMA the beta-keto makes it primarily a DARI

mmm...I'll need to dig up its numbers.

ebola

 

[blowjay]

I don't want to keep bumping too many of these old threads but my interest keeps being pushed towards the alpha-ethyl subs. I completely forgot about BDB http://en.wikipedia.org/wiki/Benzodioxolylbutanamine in the sequence of things. I hate that Shulgin gravitated so much towards the MDMA playing field after he discovered it but the fact that a few of the alpha-ethyls turn out to be enjoyable means that there is probably some fun to be had with some substitutions. I think I will make a thread about the family. If cathinones can become as popular as they did there is no reason we can't shed more light on the AEPEAs.