1-(3,4-methylenedioxy-phenyl)-2-pyrrolidin-1-yl-pentan-1-one

[AuraithX]

^MDVP & GBL is quite nice too.

 

[Ximot]

2-3mg of MDPV work well in conjunction with ethylone (50mg), 2C-i (9mg) and alcohol (beer).

 

[Canis aureus]

Most interested in about mixing MDPV or methylone with opiates... that could be interesting, or taking opiates when starting to feel come-downish...

 

[crowbar]

I find MDPV to mix well with anything. I notice next to no change in the effects of whatever I combine with it, I just feel more awake/less tired.

Thus far I've had successful combinations with MDA, LSD, Mushrooms, alcohol, Valium, and hydrocodone.

I feel that combining it with psychedelics is quite nice in that it basically removes any physical/mental exhaustion for the duration without seemingly changing the 'feel' of the trip.

 

[Jabberwocky]

Crowbar: do you experience any negative effects during or coming down from using MDPV when used alone?

Never tried MDPV, but have noticed amphetamine to very much influence the course of a psychedelic session (much beyond your alert effect, more akin to a tendency toward obsessive compulsive behavior).

 

[nuke]

With 1.0mg, orally: "Alerts in 15 minutes, peaking around 45. Kind of cloudy in the beginning, a little like the onset of MDMA, then it's clear and crisp. I feel relaxed and motivated. Zero mydriasis (my pupils only ever dilate on serotonergics). No euphoria, either. I wasn't hungry for maybe an hour or so, but I probably could have eaten. Watching a movie and cleaning the house is fun. Down in about 3 and half hour, with first the feeling that I should do more, and then the feeling of irritability which reminded me very much of cocaine. Closer to cocaine or methylphenidate than amphetamine. I think I like amphetamine better."

 

[crowbar]

Crowbar: do you experience any negative effects during or coming down from using MDPV when used alone?

I don't notice any significant come down/negativity. Only thing is when it wears off after staying up on it for 2+ days will I become extremely tired, but that's pretty much to be expected. I don't seem to require an excessive amount of sleep after staying up for such long times, nor do I feel any hangovers. To me, this stuff as a stimulant seems almost too good to be true; thusly, I try not to overindulge in it.

 

[Refluxer]

Nuke: 1 mg is a very low dose orally. I almost can't imagine feeling anything.

I recently decided to try this substance again, this time orally for the first time. I decided to try it again after, among other things, learning about Thymergix/pyrovalerone as an openly marketed pharmaceutical which had certainly been put through many toxicity tests. To get the structure of pyrovalerone you strip the 3,4-methylenedioxy off the phenyl ring and put a methyl in the 4-position instead. Ok, this difference CAN mean a lot, but probably not a difference of instantly frying axons. OR?


With 10 mgs I could definately feel effects, and redosed with same amount a few hours later. A subtle euphoria manifested, a rather distinct and mellow character. I found it good for studying - and this would be my primary reason for taking the compound now and then.

This week the pre-exam anxiety is starting to get ahold and I have a lot of pretty heavy material to read and understand before the exam. I took 10 mgs early this morning (two days using MDPV before, 2 x 10 mgs/day, orally), went to school and did some errands downtown. I planned on starting studying late afternoon and took 10 mgs more one hour before planned start. I wanted to finish some work on the computer first, and the software was being a bitch. Now I just couldn't let this go and start studying even though I didn't have to do it and I was basically "just" making some people a favour not demanded. After two hours of trying to work it out, I redosed with 5 mgs, and continued 3 hours more before it got the way I set out from the beginning.

The state was almost some kind of obsessive manic state where I had to get it done properly before I could lay it down. Afterwards I was exhausted and felt kind of burned out, suppose too much MDPV, the frustration, frenetic activity and study anxiety got to me. I regretted putting so much time, effort and energy into what I had done, because what I was doing didn't matter that much actually, it was mainly compulsive/obsessive - and I didn't like having wasted several hours of study time.

In some ways it reminded me of the compulsory/obsessive sexual/perverse/meaningless behaviours you can get on some of the more common stims, especially on the comedown. You know what I'm talking about.

In conclusion, up until now at least:

- I revided my view on MDPV and my last experiences has been it's a decent stim for some purposes but you have to be careful with dosage. IMO it shines with oral doses (If your not in it for the rush).

- Some visual effects can come, probably with higher dosing and redosages. I experienced some changes in the perception of light, it got a bit darker and more yellowish on white surfaces.

- Some confusion can be experienced even though you are completely "into" something. For example you can read sentences as something else but similar to what it really says and it can be hard to multitask in various ways. Again this probably comes more with higher dosages and redosing.


Has anyone here measured pulse and bloop pressure while on this? On several occasions and compared to your normal values?

 

[Refluxer]

Ok, so now I've taken it a few days straight in reasonable doses orally. I've also read the Meltzer article from 2006.

MDPV is a strange drug, and I can't see myself using it especially often. Maybe not at all, time will tell. The benefits do not seem to outweigh risks IMO.

 

[fastandbulbous]

^ Strange - low doses seem to be mostly side effect free. Sex (thinking about it, doing it - you name it as long as it's about sex really) does become troublesome/distracting with multi redose/large initial doses though. If you want it to enhance sex (a la meth, coke etc) I think it beats everything else hands down, it's just that if you're trying to work on any other subject/topic, once sex enters your thoughts you might as well just give up as you'll think of nothing else 'till it wears off

 

[Ximot]

/\ must try this with my wife one day then. I haven't had MDPV down as a sex aid so far.

@Refluxer: no wonder you get compuslive/reoetitive though tpatterna. 10mg isn't a super low dose, and redosing a stimulant almost always does that to me anyway. Seriously, try see what 1mg does after having abstained from all chems for 2 weeks or so. You might be surprised if you manage to tune in to the subtle "brain-tuning" fx (for lack of a better word). At 1mg or so, they're for real.

 

[Refluxer]

Actually I have barely noticed anything sexy about this compound, not even sexy-obsessive. I tried masturbating, but I couldn't tell anything unusual was going on.

Ximot: I've tried smaller doses before, but with 10 mg orally was the first time I thought I could appreciate and feel fairly good effects. Thanks for the tip though, maybe I'll try it out later and see where it takes me attention-wise.

I think MDPV has to go to the bin and 2-DPMP is next stop...

 

[hussness]

Does anyone know how this compound or pyrovalerone is metabolized? Is it mainly through reduction of the ketone to an alcohol?

 

[Dr.Heckyll]

I think MDPV has to go to the bin and 2-DPMP is next stop...

Completely agree. It was me who brought "re-invented" MDPV and brought it to the market, as a stimulant that can be easily produced and has a structure that will be recognized by users. That was in the times of PFB. MDPV also hav the advantage that it can be made by the same chemistry has methylone.

The next step will come soon, and it won't be 2-DPMP, which has its own problems. It will be something completely new and surprising, euphoric, and backed up by a solid clinical trial.

Just wait another 2 months and you will see amazing things hitting the market.

 

[Refluxer]

Dr. Heckyll: Don't tease me like that you cruel SOB! Now I'll have drewl on the ground everywhere I go thinking of all the possible structures and the tasty description...

No, but seriously. I guess you could assume several things about activity, like that it would be metabolized to some extent to the 3,4-dihydroxy compound, but did anyone publish pharmacological/SAR data on pyrovalerone analogs before Meltzer (2006)? I can't see anyone releasing a compound on the grey market without having had some in vivo tests by volontaries though. I guess some of those volontaries liked the effects of MDPV well enough.

 

[Dr.Heckyll]

Well, I guess I was the first volunteer to try MDPV, and I didn't particularly like it. The next was my wife, and she neither perticularly liked it. But the market readily accepted it, probably because of the total absence of any stimulant on the RC market.

Before Meltzer there were some old patents which I posted here about under my old name C6H6. That was the birth of MDPV. Then No names, regardless of bought 50g of MDPV from me and it made its public appearance. Never sold more than the 50g unfortunately, other people took over the business. Brainless business people unable to develop new products, but copy the products of others.

It took me some time to get back in the saddle, but now I'm working on the real deal, not just some compound like MDPV which was easy to make and made rats run faster. The RC market will see some really nice, innovative stuff in 2007 and after. And with innovative I mean not just a next shitty analog or something discussed 100 times on the boards.

Once you get in the swing of things with chemistry and pharmacology, a whole new world opens up. The mistake people are making is that they look for yet another analogue instead of searching for completely new things.

Of course it takes a lot of time and effort, and the worst part is to actually get hold of your new compounds. But hopefully at the end it pays off for everyone: the chemist and the user. And who needs a cocaine analog like CFT if you can have DEAMB GS or foxolinic acid? Structurally completely different, yet pharmacologically similar and maybe superior. Most importantly, much safer!

 

[Smyth]

I assume you are talking in coded language since ive never heard of any of those compounds except for CFT and mdpv.

More power to you if you can conjure up completely novel compounds that are worth their weight in gold but after a decade or so the creative part of my brain seems to have fizzled out.

No doubt you are quite a bit older than me, so you probably know about stuff that I have not even begun to explore. I am just curious how you can be so sure that these compounds will be successful when there is so little data regarding them.

 

[fastandbulbous]

Just wait another 2 months and you will see amazing things hitting the market.

Are we talking the 4-(3.4-dichlorophenyl)piperidine analogues (& associated phenyltropanes if you want to be all inclusive). That seems the apex of SAR when it comes to dopamine reuptake inhibitor SAR (apparently the 3,4-dichloro analouge of MDPV is the king of the heap according to the papers I've read concerning the phenylpentanones)

MDPV has such an impact on sexual behaviour as your limbic system reward centres go absolutely apeshit when the two occur simultaneously due to the flood of dopamine. Until you combine the two, you might never suspect it, but once you have combined the two the re-inforcement is almost frightening (moreso than amphetamines/coke has ever done for me & I've taken a lot of different locomotor stimulants in my time). In a way, MDPV reminds me of fencamfamine if only it didn't have that over-the-top adrenergic response once you reach a certain dose (responsible for the panic attacks and all the negative reports from MDPV

Actually I have barely noticed anything sexy about this compound, not even sexy-obsessive. I tried masturbating, but I couldn't tell anything unusual was going on.

Are you on any medication that effects either dopamine or serotonin? That's the only way I could see your non-response happening (I tried amphetamine to stimulate libido while taking Prozac for SAD. Still remained a fat eunuch - did so 'till I told my doc that I never wanted another SSRI for my SAD). Either that or is sex not a big deal for you?

 

[Refluxer]

Are you on any medication that effects either dopamine or serotonin? That's the only way I could see your non-response happening (I tried amphetamine to stimulate libido while taking Prozac for SAD. Still remained a fat eunuch - did so 'till I told my doc that I never wanted another SSRI for my SAD). Either that or is sex not a big deal for you?

No meds at all. Before I decided to reevaluate MDPV I had a period where I used another common stimulant frequently, but in pretty low doses (i.e. a few days, then a day or two break). I did develop a mild tolerance during that period, but took a few days break before trying MDPV. I guess that could be a probable reason. But still, not a hint of sexuality, while on more common stims I can get really stuck in sexual thinking, like you describe. Once the fantasies start flowing or you see something sexually oriented - BAM! And it's hard to let it go.

 

[Refluxer]

Before Meltzer there were some old patents which I posted here about under my old name C6H6. That was the birth of MDPV. Then No names bought 50g of MDPV from me and it made its public appearance. Never sold more than the 50g unfortunately, other people took over the business. Brainless business people unable to develop new products, but copy the products of others.

Haha, some time ago I've thought about asking them if they wanted to buy consulting services so they could get suggestions on new chemicals to add to their directory, as they seemed unable to come up with new products.

It took me some time to get back in the saddle, but now I'm working on the real deal, not just some compound like MDPV which was easy to make and made rats run faster. The RC market will see some really nice, innovative stuff in 2007 and after. And with innovative I mean not just a next shitty analog or something discussed 100 times on the boards.

I think you're my new hero in this niche, it has really been stagnant for some time as most actors on the market are only involved in it for the cash. Nothing bad with making money off it, that's a clear driving force, but all love for those who have a genuine interest and actually furthers this underground science.

The last decades rise in research chemicals as drugs has both good and bad sides. One cannot ignore risks, and possible personal tragedies, involved in supplying the global market with often unresearched chemicals like this (as it is hard to make an educated risk assessment with scarce or non existent studies on the compounds). On the other hand the underground chemistry and psychopharmacology complements the official disciplines in the sense that it pushes things forward whether or not it is liked. Sooner or later official research will be done (latest seen in Eur. Journal of Pharmacology) on these compounds just because they exist and people use them. And this will further the understanding of the brain and psyche. It has mostly been old compounds, but this will change as PIHKAL and TIHKAL has gotten watered down but the demand is still just as high.

Of course it takes a lot of time and effort, and the worst part is to actually get hold of your new compounds.

In what way do you mean that's the worst part? Isn't that one of the best parts? :D I guess if you have to deal with for example chinese labs, the cultural and language barriers can make it hard, unless one is a businessman used to making business in the area.