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Benzos ⫸Benzo Guide v.1⫷

How should I taper off lorazepam (Ativan) when I've been taking doses of 0.5mg - 1mg on and off since 3 weeks ago, but 1 mg every night for the last 3 nights or so?

I'm schizophrenic too, so keep that in mind
 
We need to add lipid solubility, even if it is relative (low for Lorazepam, very low for clonazepam, medium for temazepam, HIGH for diazepam , medium high for nordazepam

Just an example. I already have references for the common Benzodiazepines in this very thread, so that information should be added.

Also an explanation on half-life vs Duration of Action

These are the finishing touches, I can't do it moderators so please add the info
 
Also I want Credit for my contributions, that says KK's guide though he was absent when it was updated - he may have made more contributions though later

Then again no one else receives any credit so hey
 
Important note - clobazam is a 1,5-benzodiazepine (all others are 1,4-benzodiazepines) and so it does not bind to the same GABA junctions. That means that it will not prevent abstinence syndrome in people depend on another (and therefore a 1,4-benzodiazepine).

Most doctors, even specialists did not know this. I had to contact Ashton and get her to modify her manual (and heck did she hate being wrong). So now people are transferred over 14 days.

Clobazam has a ceiling it it's effects. Beyond about 40mg, it won't do anything more, however many you take. This makes them much less abusable. The UK has JUST worked that one oud.
 
Throwdown said:
Lorne I know you obviously have a really good knowledge in this area but no lie i literally don't understand 90+% of your posts. Loads of scientific abbreviations and mad words its so confusing. I'm sure I' not the only one.

Maybe try simply the information so it's easier to read?

Just a friendly word of advice i mean no disrespect.
Click to expand...
Fully agree sounding smart also makes ya seem not as you believe.I reckon I'd near give ya a run for ya money.
 
this is a fine thread you all have here. I have been tasked with creating a small HR article on the topic of HR/Safety Tips for the use of RC Benzos. I don't actively use them, and with such potency and lack of oversight in knowing which compound is which, it's hard for me to imagine hr other than "don't do rc benzos" which is obviously not going to help someone already doing that. So any tips for testing, safe preparation, what to do in overdose, how NOT to have these things happen. Interested to see how these knowledgeable posters reduce the harm from these compounds. doesn't need to take up thread space, unless that is wanted here in the benzo guide thread. feel free to DM me. Thank you/party on.
 
What would be your qualifications Lorne? I mean this with all humbleness and care, about the benzos and opiates?
 
Lorne??? said:
We need to add lipid solubility, even if it is relative (low for Lorazepam, very low for clonazepam, medium for temazepam, HIGH for diazepam , medium high for nordazepam

Just an example. I already have references for the common Benzodiazepines in this very thread, so that information should be added.

Also an explanation on half-life vs Duration of Action

These are the finishing touches, I can't do it moderators so please add the info
Click to expand...

Lipid solubility? I presume you intend to use Lipinski's Rules of 5 (RO5) to predict onset, distribution, metabolism and excretion?

LogP is the term to search for. It's the ratio of distribution of the drug in fat (like the brain) and water (much like blood).

As the name suggests - it's the logarithm of the lipid : water partition.
 
I started dating a MD's daughter when I was 18, had been injecting opiates and synthetics for a couple of years before that. I didn't just have all the pharmacies but the medical books to learn what to do with what. That started out as a great time has turned into a living hell for 42 years, if it was made and strong enough as morphine, demerol, Dilaudid, heroin, fentanyl, benzos, amphetamine and on & on I've been strung out on it. Alcohol was always a good filler later whenever my choice, which didn't really matter, was not available. Been to every treatment that money and no money can get. These ( holistic plants, fungi, cacti and other ancient knowledge hidden from us is the only relief I have found. Yeah I know tapering which is the safest way off most powerful, dangerous pharmaceutical but then what. Relapse is like 80%, this I know,seen it, experienced it while watching my friends die. It's a broken system. I see nature and the beauty of it's medicine as our only hope.
 
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