Search results for query: SSRI and cocaine

Hello all! 1. Maybe a few months? Don't remember exactly. Now I've decided to join. 2. I read about forum on its polish version. ;) 3. I've tried various medications (benzodiazepines, neuroleptics, SSRI). I've smoked marijuana. I've taken cocaine, amphetamines, crystal (klefedrone, mephedrone)...

They both bind at the same site on DAT/NET/SERT. Only difference is their selectivity: (+)Amph is more potent at DAT~NET than (+)Meth but way less active at SERT. Actually even cocaine-like pure reuptake inhibitors (MPHs, pyros, desoxy,..etc) bind same site. Highly potent DNRIs like mazindol...

Thank you for your expertise and knowledge on how this structure is. I always thought that front attachment was responsible for the empathy because having taken the Real pure MDMA of 90's no question about that and pure Methylone ... having to triple dose the Methylone seemed to prove same...

Yea don’t get me wrong I still take .75mg of suboxone a day, and cannabis. But I didn’t need all the benzodiazepines, gabapentin, SSRI’s, and more that they felt I needed. I think people brush it off cuz it seems too simple, right. We feel our complex problems need complex solutions, but...

Oh yeah, bring back that para-methylated serotonin goodness! It's a shame that 4,4'-DMAR had to take such a death toll just because of reckless capitalist vendors. This stuff was indeed amazing! At 25-50mg I was like 10 days constantly rolling, even when each one was slightly less intense than...

TLDR: What drugs would you recommend that are dopaminergic? (help with increasing levels of dopamine, dopamine receptor stimulation, dopamine release). I came here looking more drugs off the beaten path, of course we all know about cocaine and meth being stimulants. Regarding dopaminergic...

I’m prescribed Zyprexa, lamictal xanax at night and Adderall throughout the day. because of the SSRI’s I’ve had to research when doing recreational drugs. And noticed my meds keep my serotonin level.. I think.. anyway I can’t trip, if I take lsd dmt or shrooms I just get a weird stimulative...

LucidSDreamer …..you prefer Valium to opioids? ….”it’s now an opioid should feel” Have you ever tried oral Oxycodone while being opioid naive? Opioids derived from morphine tend to be very sedating, although still producing euphoria. Oxycodone is synthesized from the alkaloid theBaine (not...

I've only done 4,4-DMAR once and there was VERY little info about possible safety and dosages at the time (~2013). I binged a whole gram in like 8 hours. It started out like a really clear headed roll but by the end the shadow people were out in full color but I had zero anxiety about them...

Cocaine Made me bicurious AND ended up getting my. Dick fucked by my friend. It was outstanding blow btw.

I think i might prefer the benzos now because I’m new to benzos and have a 15 year opioid history and the opioid I have now is the least euphoric one I’ve ever done…methadone At first I thought Valium sucked because it takes so long to kick in and I was waiting for that instant hit you get from...

Hey, so benzos dont block opiates and vice versa, infact a dangerous combo. And yeah you dont want to experience benzo wd, just thought i would drop a few words. Hope you get things sorted.

I was on Heroin for over a decade. Just that. I was a painfully loyal lover of Mr. H. I didn't cheat on him with Cocaine, Esctacy, or other stimulants. I was a downer 100%. Then i got on Methadone. For 13 fuckin years. I tapered from 80mg at the start to 40mg then i just take 40-30mg for the...

Hello. How do NAC, magnesium and taurine interact with amphetamines? I was considering trying Taurine to relieve the inability to focus when I am taking vyvanse. Have you developed any more ideas about uridine and Sulbuthiamine?

I should probably note I WAS drinking off-and-on during the methadone withdrawal, which aided in things like anxiety and sleep. I was only on like 50mg but was using small amounts of heroin, so had the methadone increased to 65mg and quit the heroin cold turkey that day. It went totally fine...

My last 5 or so MDMA trips were hell on earth. No other drugs, just the MDMA, not even alcohol or weed. Huh, I honestly don't know MANY people that had a bad reaction to weed. Maybe 5-10 who said they didn't like it to about a 100+ that did and do. I don't know maybe it's the different...

I know that all SSRI's affect serotonin, but methamphetamine is a dopamine releaser first and foremost, over serotonin, right? That's the part i'm confused about. Anyway, that's a drag 😣 But it might explain why I have such a hard time reaching a satisfying high when I try to smoke these days...

Never mix tramadol and cocaine, specially if you're taking +400mg of tramadol a day, that's a very dangerous combo. Tramadol+cocaine+alcohol is a ridiculous combo, even more so because cocaethylene is more toxic and longer lasting than cocaine. People have died from that. If you know your...

Just some background context, i was depressed since early 2020, and tried to use high-dose stimulants and SSRIs in order to just be able to feel normal. But the problem is that it was not sustainable, and created too many side-effects, specially the comedown was, for lack of better words...

This is purely anecdotal and also likely redundant since we know the dangers of SSRIs+(most) stimulants, but since many people ignore these dangers - myself included - and even do so without ill effect (serotonin syndrome) I feel it is relevant to mention. Perhaps it might help somebody. A...