Harm Reduction Probably a stupid idea, but… Auvelity + 4-MMC?

[crazyotter87]

Soooooo, I got some HQ mephedrone a while back that I’ve been sitting on. Anyway, I’ve been sober for three weeks now and am taking a little break from drugs.

I started taking Auvelity (45mg DXM/105mg bupropion) a little over a week ago. (Slightly off-topic, but this is the best antidepressant I’ve ever tried. Robotrippers were really light-years ahead...)

With Halloween coming up, though, I’m really tempted to break out the MKAT. Can anyone share any insight into the potential interactions or any personal experiences with this combination?

I know bupropion lowers the seizure threshold, which kinda worries me. Serotonin syndrome is a concern too, obviously, but I’m not as worried about it (it’s not like I’m planning on taking aMT and MDMA). Honestly, I’m more worried about having a seizure alone in my apartment lol.

I realize this might be a pretty moronic idea, but I figured I’d ask before doing anything.

Thank you ;-)

 

[SuperPsych]

Soooooo, I got some HQ mephedrone a while back that I’ve been sitting on. Anyway, I’ve been sober for three weeks now and am taking a little break from drugs.

I started taking Auvelity (45mg DXM/105mg bupropion) a little over a week ago. (Slightly off-topic, but this is the best antidepressant I’ve ever tried. Robotrippers were really light-years ahead...)

With Halloween coming up, though, I’m really tempted to break out the MKAT. Can anyone share any insight into the potential interactions or any personal experiences with this combination?

I know bupropion lowers the seizure threshold, which kinda worries me. Serotonin syndrome is a concern too, obviously, but I’m not as worried about it (it’s not like I’m planning on taking aMT and MDMA). Honestly, I’m more worried about having a seizure alone in my apartment lol.

I realize this might be a pretty moronic idea, but I figured I’d ask before doing anything.

Thank you ;-)

I wish that I could provide some actual experience or research, but this sounds like something to avoid. Bupropion and DXM both inhibit liver enzymes, and have a sort of entourage effect in doing so.

I haven't done the research myself to see how 4-MMC is metabolized or if the enzyme inhibition would be something to worry about.

The lowered seizure threshold and Serotonin Syndrome are both risks to be mindful of. I imagine seizures and/or serotonin syndrome would be possibilities. Probability, however, I couldn't say.

Best course of action would be to taper off of the Auvelity for a week or so if possible before trialing the 4-MMC. If you must continue the Auvelity daily, then I'd at least skip it the day of the 4-MMC experiment and start slowly until you feel that it's safe.