SassysShrooms
Greenlighter
- Joined
- Oct 21, 2026
- Messages
- 2
I’ve been a long-time believer and researcher of the classic LSA + aldehyde “adduct” theory. I want to say sorry in advance to Tregar if this alternative framing undercuts some of his work — I’ve always respected his research and the effort he’s put into the community.
Over the past 10 years I’ve done a lot of experiments with different aldehydes and aromatic compounds alongside LSA (morning glory / HBWR). Many of them produced noticeably different effects — sometimes it felt like a completely different drug than plain LSA.
I recently came across this Google patent from Goodcap Pharmaceuticals:
They researched combining 5-HT2A agonists (psilocybin, LSA / lysergic acid amide, lysergic acid α-hydroxyethylamide from morning glory and Hawaiian baby woodrose seeds, and others) with various TRP receptor agonists. The core idea is multimodal action at both 5-HT2A and TRP channels (TRPV1, TRPA1, TRPM8, TRPV3, etc.). This can allow lower doses of the 5-HT2A compound while changing the overall effect profile — more euphoria, altered duration, reduced anxiety or body load in some combinations, better anti-inflammatory effects, etc.
Interestingly, many of the classic “LSA adduct” herbs are listed in the patent as TRP agonists:
Peppermint (menthol → mainly TRPM8)
Cinnamon (cinnamaldehyde → strong TRPA1)
Clove (eugenol)
Cayenne (capsaicin → TRPV1)
Turmeric (curcumin)
Black pepper (piperine)
Nutmeg (myristicin — which they note can also have some 5-HT2A activity itself)
Plus oregano, thyme, ginger, garlic/onion (allicin), bergamot, cardamom, chocolate/cocoa, myrrh, frankincense, and others.
The patent’s strongest practical observations are mostly with psilocybin + the spice combination of cayenne + turmeric + clove + cinnamon + nutmeg (sometimes with chocolate or bergamot). They describe clear synergies: nutmeg increasing euphoria, turmeric prolonging effects and reducing anxiety, cayenne speeding onset and improving pain relief (while sometimes increasing anxiety), etc. Morning glory and HBWR seeds are explicitly listed as usable 5-HT2A sources in the same framework.
This made me rethink the old adduct idea. A lot of the same materials that people used for “aldehyde potentiation” are simply good TRP agonists. The change in effects may be coming from receptor-level interactions (5-HT2A + TRP) rather than a chemical adduct forming between LSA and the aldehyde.
That still left the question of wine, sherry, and other acetaldehyde-containing drinks, which many of us have noticed can also shift LSA in a similar stimulating/euphoric direction. Acetaldehyde itself is a documented TRPA1 agonist so it fits the same pattern without needing an adduct.
The notorious Isovaleraldehyde interacts with transient receptor potential (TRP) channels—primarily TRPA1 and TRPV1—acting as a chemical agonist that drives sensory irritancy, trigeminal pungency, and respiratory reflexes. reactive aldehydes like isovaleraldehyde typically interact with TRP channels via covalent protein modification
Other relevant points:
Garlic (allicin) has long been used for nausea with these seeds — it’s a TRP agonist.
Black pepper is a classic TRP agonist.
There’s an old report about mustard powder (allyl isothiocyanate is a strong TRPA1 agonist) producing more visual/LSD-like effects.
Cuminaldehyde (from cumin) is also a TRPA1 agonist.
I tested the idea with psilocybin: a packed 000 capsule of mushrooms (roughly 0.3–0.4 g) + 2 drops of peppermint oil. It produced the same kind of shift I used to get with LSA — noticeably more euphoric and stimulating, plus the candy-cane flavored burps.
I also suspect this framework explains a good chunk of the old “oilhuasca” / space-paste observations. Many of the classic space-paste ingredients (turmeric, black pepper, cinnamon, clove, cayenne, etc.) are exactly the TRP agonists the patent highlights. There are probably enzyme and absorption effects in the mix too, but the TRP angle seems like a big piece that was missing.
I did write this all myself but then used AI to touch it up. I am a drug using sasquatch, not an English professor.
Over the past 10 years I’ve done a lot of experiments with different aldehydes and aromatic compounds alongside LSA (morning glory / HBWR). Many of them produced noticeably different effects — sometimes it felt like a completely different drug than plain LSA.
I recently came across this Google patent from Goodcap Pharmaceuticals:
WO2022079574A1 - Compositions for reducing inflammation to improve or maintain mental or physical health - Google Patents
The present disclosure provides compositions and methods for reducing inflammation to improve or maintain mental health or physical health in an individual. In some aspects, the compositions include at least one 5HT2A agonist and at least one TRP agonist, wherein the therapeutically effective...
patents.google.com
They researched combining 5-HT2A agonists (psilocybin, LSA / lysergic acid amide, lysergic acid α-hydroxyethylamide from morning glory and Hawaiian baby woodrose seeds, and others) with various TRP receptor agonists. The core idea is multimodal action at both 5-HT2A and TRP channels (TRPV1, TRPA1, TRPM8, TRPV3, etc.). This can allow lower doses of the 5-HT2A compound while changing the overall effect profile — more euphoria, altered duration, reduced anxiety or body load in some combinations, better anti-inflammatory effects, etc.
Interestingly, many of the classic “LSA adduct” herbs are listed in the patent as TRP agonists:
Peppermint (menthol → mainly TRPM8)
Cinnamon (cinnamaldehyde → strong TRPA1)
Clove (eugenol)
Cayenne (capsaicin → TRPV1)
Turmeric (curcumin)
Black pepper (piperine)
Nutmeg (myristicin — which they note can also have some 5-HT2A activity itself)
Plus oregano, thyme, ginger, garlic/onion (allicin), bergamot, cardamom, chocolate/cocoa, myrrh, frankincense, and others.
The patent’s strongest practical observations are mostly with psilocybin + the spice combination of cayenne + turmeric + clove + cinnamon + nutmeg (sometimes with chocolate or bergamot). They describe clear synergies: nutmeg increasing euphoria, turmeric prolonging effects and reducing anxiety, cayenne speeding onset and improving pain relief (while sometimes increasing anxiety), etc. Morning glory and HBWR seeds are explicitly listed as usable 5-HT2A sources in the same framework.
This made me rethink the old adduct idea. A lot of the same materials that people used for “aldehyde potentiation” are simply good TRP agonists. The change in effects may be coming from receptor-level interactions (5-HT2A + TRP) rather than a chemical adduct forming between LSA and the aldehyde.
That still left the question of wine, sherry, and other acetaldehyde-containing drinks, which many of us have noticed can also shift LSA in a similar stimulating/euphoric direction. Acetaldehyde itself is a documented TRPA1 agonist so it fits the same pattern without needing an adduct.
The notorious Isovaleraldehyde interacts with transient receptor potential (TRP) channels—primarily TRPA1 and TRPV1—acting as a chemical agonist that drives sensory irritancy, trigeminal pungency, and respiratory reflexes. reactive aldehydes like isovaleraldehyde typically interact with TRP channels via covalent protein modification
Other relevant points:
Garlic (allicin) has long been used for nausea with these seeds — it’s a TRP agonist.
Black pepper is a classic TRP agonist.
There’s an old report about mustard powder (allyl isothiocyanate is a strong TRPA1 agonist) producing more visual/LSD-like effects.
Cuminaldehyde (from cumin) is also a TRPA1 agonist.
I tested the idea with psilocybin: a packed 000 capsule of mushrooms (roughly 0.3–0.4 g) + 2 drops of peppermint oil. It produced the same kind of shift I used to get with LSA — noticeably more euphoric and stimulating, plus the candy-cane flavored burps.
I also suspect this framework explains a good chunk of the old “oilhuasca” / space-paste observations. Many of the classic space-paste ingredients (turmeric, black pepper, cinnamon, clove, cayenne, etc.) are exactly the TRP agonists the patent highlights. There are probably enzyme and absorption effects in the mix too, but the TRP angle seems like a big piece that was missing.
I did write this all myself but then used AI to touch it up. I am a drug using sasquatch, not an English professor.
food for thought.
