Because I placed an order with a vendor and they sent the wrong pharm. Now im stuck with 300 tabs of this.
1000mg of tapentadol, even if u already have a high tolerance for opioids is very high dose which usually results at strange, very noticable mind altering effects little bit ( a lot ) different than classic agonists and tramadol feels different too.
Tapentadol produce strange mixture of noddy + diphenhydramine-like effects ( anticholinergic delusions ) + classic sedation and it should be relatively noradrenergic but this aspect of tapentadols mind alterning effects is much, much less noticable than for example that of tramadols noradrenergic part of mental effect.
If u are at least capable to metabolize tramadol to M1 at normal rate ( functional but not ultrarapid cyp2d6 metabolism ) than 1000mg of tramadol will result in noticable opioid effect with absolutely profound monoaminergic speedy semi-amphetamine effects creating mental high comparable to 80-100mg oxy + dose of amphetamine ( can't tell u how much of racemic amphetamine feels close to that monoaminergic aspect of 1000mg tramadol mental effects because it's highly individual and it's just one part of tramadols high - the other part is produced by effective full mu-opioid agonistic effects of O-DSMT which can be STRONG if u are repid cyp2d6 metaboliser and if u take enough for effects to manifest - this depends also on your tolerance.
But in case of being effective cyp2d6 metaboliser taking 1000mg tramadol results at absolutely noticable speedy+opioid effects.
Taking 1000mg of tapentadol should provide this speedy effect too but for some reason it doesn't. It is more like opioid + deliriant kind of high.
! FOR HARM REDUCTION PURPOSE I ADVICE TO NOT TAKE MORE THAN 700MG OF TAPENTADOL WITHOUT TAKING EFFECTIVE ANTICONVULSANT TOO - for example some diazepam. !
Tramadol requires anticonvulsant agent to be taken if u take more than 400mg ( it's 300mg less than in case of taking tapentadol because speedy aspect of tramadol is much more complex - it's not only NRi but it's SNRi of parent compound, serotonine releasing effect of parent compound and on top of this all even M1 ( O-DSMT ) provides further NRi effects so, it's like total monoaminergic overload combined with indirect dopamine boost from effective opioid mu-agonism and decrease in GABA.
I provided complete explanation of tapentadol and it's effects and for further understanding of 2 atypical opioids mechanism of action I provided information about tramadol too ( why it feels like it feels and what's the difference between 1000mg dose of tapentadol and 1000mg dose of tramadol - two atypical opioids with some simmilar pharmacologic properties but with somehow very different subjective feelings produced by them ).
One last information = Tapentadol has biological half-life of 4-5 hours, Tramadol has biological half-life of 6-7 hours and M1 ( O-DSMT, active metabolite which is full opioid agonist and noradrenaline reuptake inhibitor ) has biological half-life of 8 hours and after repeated dosing it's half-life is prolonged and reach 9 - 11 hours. Tramadol is considered short acting opioid prodrug and it's often compared to codeine but codeine and it's active opioid metabolites are really short acting. Codeine, morphine and C-6-G biological half-life can reach 4 hours. But tramadol and it's metabolites have biological half-life approximately 2x or 2,5x longer.
It was created like this on purpose - there was a need for longer lasting and less sedating opioid pain medication. So they created long-acting opioid + monoaminergic hybrid.
