Also, naloxone having limited effects when used as directed doesn't mean it has “zero effect on anything.” Please provide reliable sources for claims about carcinogenic ingredients or manufacturers deliberately causing harm.
Here's the inactive in "Dr Reddy's Buprenorphine/Naloxone" strips.
| ACESULFAME POTASSIUM (UNII: 23OV73Q5G9) | |
| AMMONIA (UNII: 5138Q19F1X) | |
| ANHYDROUS CITRIC ACID (UNII: XF417D3PSL) | |
| BUTYLATED HYDROXYANISOLE (UNII: REK4960K2U) | |
| BUTYLATED HYDROXYTOLUENE (UNII: 1P9D0Z171K) | |
| FD&C BLUE NO. 1 (UNII: H3R47K3TBD) | |
| FD&C YELLOW NO. 6 (UNII: H77VEI93A8) | |
| MALTITOL (UNII: D65DG142WK) | |
| Polyethylene Glycol, Unspecified (UNII: 3WJQ0SDW1A) | |
| POVIDONE K29/32 (UNII: 390RMW2PEQ) | |
| POVIDONE K30 (UNII: U725QWY32X) | |
| SHELLAC (UNII: 46N107B71O) | |
| SODIUM PHOSPHATE, DIBASIC, ANHYDROUS (UNII: 22ADO53M6F) | |
dailymed.nlm.nih.gov
Butylated hydroxyanisole you say?
"Reasonably anticipated to be a human carcinogen"
www.ncbi.nlm.nih.gov/books/NBK590883/
"Butylated hydroxyanisole (BHA) is classified as a possible human carcinogen by groups like the National Toxicology Program and the International Agency for Research on Cancer, though experts note that the tumors seen in animal studies occur in a part of the stomach rodents have that humans lack"
So the consesus is
"we're not totally sure yet, but we're gonna use it anyway".
Pretty sure a number of those ingredients are questionable. And they vary by manufacturer. For example, some of the tablets use Acesulfame, Sucralose & other sweeteners which are also identified as "possible carcinogens". And almost every generic brand of Suboxone cotains BHA, along with various other shit. I literally had to sit through various inactive ingredients lists years ago to figure out which brand of Subs was causing me unexplained health issues. So you can bet I've sifted through various inactive ingredients in all the Suboxone generics & looked into a lot of them.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8946744/ :
"Conclusions
In this large cohort study, artificial sweeteners (especially aspartame and acesulfame-K), which are used in many food and beverage brands worldwide, were associated with increased cancer risk. These findings provide important and novel insights for the ongoing re-evaluation of food additive sweeteners by the European Food Safety Authority and other health agencies globally."
There's always the possibility that the sweeteners themselves aren't carcinogenic, but they do have connections to obesity & disruption of the microbiome.
Some of the other generics also use the same ingredients but also have different ingredients too that are questionable.
I had to finally settle with a brand that uses Sucralose as a sweetener. Though, I'd rather not having of these bullshit sweeteners in there, period. So I don't know why you're hassling me over the fact that I don't want to put useless ingredients in my mouth or body.
Also, I don't care if they tell you to "rinse your mouth out/spit afterwards". Have you ever actually used any of these damn products? You can rinse & rinse & that flavor will still be all over your mouth, cheeks & tongue 30 minutes later some times. Also, just because you're not swallowing them, doesn't mean they aren't absorbing into your mucus membranes either. I can't confidently say yet if the sweeteners and preservatives can do that, but I wouldn't be surprised. And in many cases, especially if you're on 2-3 strips a day, you are inevitably swallowing some of that shit regardless. And think about putting 3 strips in your mouth every day for 10-20 years, you think "just spitting/rising" means you're fine? C'mon now.
While there's no "direct link" yet between Suboxone & oral cancer, there are cases that have come out recently.
This is the only case I can find, but I don't think it invalidates anything. I just pointed out how there are multiple "possible carcinogens" in the inactive ingredients. Some one ending up with oral or throat cancer after long term use doesn't seem so unrealistic at that point.
And yes, I have been on both buprenorphine/naloxone & just mono-buprenorphine. There is absolutely ZERO subjective difference to me whatsoever in the two. Plus the binding affinity for buprenorphine is so much higher than naloxone, that the naloxone is not going to "block" the buprenorphine (not mention, why would you WANT naloxone to BLOCK a drug meant for craving & withdrawal relief to begin with?).
Naloxone is also short lived, so even if it did do anything, the buprenorphine would take over after a half an hour anyway.
And if you're an IV user, you're going to have precipitated withdrawal from both Suboxone AND Subutex, because it's not the "naloxone" that induces withdrawal, it's literally the buprenorphine itself, because it is a mixed partial agonist & an antagonist. This happens regardless of how you take it too. If you're dependent on a full agonist & take buprenorphine IN ANY FORM too early, you will go into withdrawal, whether it's through an IV or under the tongue as prescribed. I'm not an IV user, but I've thrown myself into WD using subs under the tongue many times a decade ago. So ultimately IV use should be deterred whether the naloxone is present at all.
So ultimately, yes, the naloxone is completely useless, except deterring uneducated drug users who believe everything that's hand-fed to them by anyone with authority & know's squat about pharmacology. If anything, I feel like the quick wash of naloxone over the receptors might even sensitize them to make the bupe even more effective, similar to how low-dose naltrexone can be used to lower & reset opioid tolerance. But the way they market Suboxone as a "safer alternative" is absolutely a gimmick & I've just described exactly why.
Also, while not directly considered a carcinogen, you can throw Yellow No.6 on the last as well -
Yellow No. 6 (Sunset Yellow FCF) is not classified as a direct human carcinogen, but it raises health concerns because
it can be contaminated with trace amounts of benzidine, a known human carcinogen.
Most of these ingredients are completely useless. Do adults REALLY need their medicine to be "lemon-lime" flavored in order to use them? I sure as hell don't. I also don't need it to come in fun colors like "orange" or whatever the fuck. These medicines can be made much cleaner if manufacturers or the country actually gave two shits. These aren't small pills either. For 8mg, a generic Suboxone pill is almost certainly bulked up with 90% all this other crap.
Funny, generic Subutex pills are really tiny & don't need all these ingredients.
No one's telling anyone to abruptly "stop treatment". People have a right to know what they're putting in their mouths & bodies though, because nobody else is going to tell them. People should have the right to know that
"hey, if you're using Dr Reddy's generic Suboxone strips (and pretty much any form of Sublingual bupe/naloxone), especially at high doses, you're putting Ammonia & possible carcinogens in your mouth every day". And yes ammonia can be naturally occurring in foods & safe in small doses, but we are not talking about foods. We are talking about drugs that people have to take 2-3 of a day & hold under the tongue for 15-20 minutes. If you don't hold it long enough, it may not all absorb & then you could feel off that day. So eating a food with a little ammonia or Yellow No.6 ain't going to hurt you, but think about placing those thing on something sensitive like a mucus membrane, which you then have to hold it there for a lengthy of period of time, every single day, for years to decades at a time.
As for asking for "proof of intent to harm people", that is my OPINION. I never said it was FACT. And I came to that OPINION by the obvious fact that all of this garbage DOES NOT NEED TO BE in these pills & strips. I BELIEVE they only do it because A) capitalism/greed (can charge more the more stupid inactive ingredients you put in) and B) to keep people sick & coming back for more medicines & "healthcare".
Instead of looking up the inactive ingredients & looking into them yourself, you made me prepare an entire essay for you instead.
