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The Big & Dandy Syrian Rue & Harmala MAOI Alkaloids Thread

rearranging (synaptic plasticity) vs birthing new/keeping alive (neurogenesis/neurogenic plasticity):
harmine/THH particularly interesting regarding the latter.
edit: it may be better to stagger these with synaptic plasticity instead of simultaneous use, balancing them at 1:1 or 2:1
 
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rearranging (synaptic plasticity) vs birthing new/keeping alive (neurogenesis/neurogenic plasticity):
harmine/THH particularly interesting regarding the latter.
edit: it may be better to stagger these with synaptic plasticity instead of simultaneous use, balancing them at 1:1 or 2:1
More on this?
 
distinguishing the two:

"rearranging" the ability to strengthen, weaken, or reorganize what is all ready there.
Usually referenced when discussing mushrooms/LSD.

"regenerating": healing, keeping alive and incorporating.
Harmine and THH (Tetrahydroharmine) are alkaloids used to inhibit an enzyme called DYRK1A. When this enzyme is blocked, neurogenesis (the latter process). It doesn't happen instantly though, so staggering the two (instead of taking them together like ayahuasca) might be better.



theoretical ideal ratio: 2:1 H/THH
 
"…and this is coming from a guy who has taken Harmalas, in full/heavy dosages, daily pretty much, for 12 straight years and ongoing,"[1]

"Aya was my first ever Psychedelic, and i took it all on my own (even from the get go) and ended up taking it daily/near daily for 4 years straight,"[2]

"i'm a much better person for having worked with Ayahuasca and i owe my life to it, i absolutely do not know where i would be today had i not worked with Ayahuasca, so much has happened in my life because of working with Ayahuasca that i wouldn't be who i am today without it,"[3]

1. Sabnock101  2024-07-10  h‍ttps://www.reddit.com/r/Ayahuasca/comments/1dza5kg/comment/lchaxri/

2. Sabnock101  2024-07-09  h‍ttps://www.reddit.com/r/Ayahuasca/comments/1dza5kg/comment/lcf92rb/

3. Sabnock101  2024-07-10  h‍ttps://www.reddit.com/r/Ayahuasca/comments/1dza5kg/comment/lcgzj4f/
 
in low doses and especially when taken regularly, it's not exactly the same as a microdose, it's something more profouind, more "religious" or "spiritual" feeling if that makes sense. The impact it has on senses and physical capacities also should not be overlooked. I was capable of dramatically more as far as calishtenics, cardio, I was suddenly doing shit at the skatepark as if I'd been skating for years longer than I had.

Are you saying that low-dose B. caapi is superior to a microdose of psilocybin or LSD?

If you can elaborate on anything else you mentioned, it would be appreciated.
 
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• Harmala compounds are pre-oneirogens; ie. they induce a state between falling asleep & hypnagogia where our conscious awareness goes beyond our physical body.

• The experience is like wakeful dreaming, combined with remote-viewing & archetypal imagery.

• These oneirophernic states has been practiced is shamanic voyages, and mystical rituals for accessing the divine.
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instagram.com/ancestralmagi/p/DIM4Daev7kd/  2025-02-08
 
"People do report that Banisteriopsis caapi does have psychoactive properties in its own right." Erowid. https://erowid.org/experiences/exp.php?ID=33549

"With the resurgence of research on psychedelics[13], the β-carbolines of B. caapi have been considered to play a minor role in the overall pharmacology of ayahuasca preparations. However, this is probably a narrow view. B. caapi is the common ingredient to all ayahuasca brews, and chemical analyses have shown that while the β-carbolines are present in all ayahuasca samples, this is not always the case for DMT[14, 15]. For instance, an ayahuasca sample from the Brazilian Church União do Vegetal, a group known to regularly combine B. caapi with P. viridis in their ayahuasca, was found to contain no DMT at all[16].

13. Sessa, B. Shaping the renaissance of psychedelic research. Lancet Lond. Engl. 380, 200–201 (2012).

Article  Google Scholar

14. Rivier, L. & Lindgren, J. E. ‘Ayahuasca’, the South American hallucinogenic drink: an ethnobotanical and chemical investigation. Econ. Bot. 26, 101–129 (1972).

Article  CAS  Google Scholar

15. McKenna, D. J., Towers, G. H. & Abbott, F. Monoamine oxidase inhibitors in South American hallucinogenic plants: tryptamine and beta-carboline constituents of ayahuasca. J. Ethnopharmacol. 10, 195–223 (1984).

Article  CAS  PubMed  Google Scholar

16. Callaway, J. C. Various alkaloid profiles in decoctions of Banisteriopsis caapi. J. Psychoactive Drugs 37, 151–155 (2005).

Article  CAS  PubMed  Google Scholar

Morales-García, J.A., de la Fuente Revenga, M., Alonso-Gil, S. et al. 2017. The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro . Sci Rep 7, 5309. doi.org/10.1038/s41598-017-05407-9
Introduction


"This bias towards visions and DMT clashes with the ethnographical evidence of local use. The terms most widely used for the medicinal brew—ayahuasca (in Peru and Brazil) and yajé (in Colombia)—refer both to the vine and to the brew itself, whether or not it contains chacruna. Some ethnic groups only cook the vine, without any additives, like the Tucano Oriental, the Marubo, the Achuar and the Matsiguenga."

Carlos Suárez Álvarez. Why You Will Never Get a Traditional Ayahuasca Treatment. 2017-08-10. chacruna.net/you-will-never-get-traditional-ayahuasca-treatment/
The Purge and the Visions
 
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