depends on what drugs i’m doing, i don’t have the same reaction to them all. opioids and benzos i feel a slightly fiendish excitement, looking forward to the pleasure and the relief from my severe and chronic pain/anxiety. ketamine is the same.
on the other hand before taking psychedelics i’m filled with a debilitating anxiety almost tipping over into dread. i absolutely love psyches, but ive had some really intense and difficult trips. none that i would really call “bad” but intense. having such intense experiences and undergoing such effects has not only given me a major respect for what the drug can do, but they’ve given my body an almost physiological reaction. knowing that i’m going to trip and undergo that fills my body with anxiety. i get the same with MDMA, albeit to a lesser extent. i don’t feel much before weed, tho nowadays while ON weed i get crippling anxiety and panic, which has made me get anxious if i decide to use it on the rare occasion i do
i can’t really speak to, cause i haven’t done much in a long time. no amphets in 7 years, coke a couple times since. but it’s similar to opioids but it’s much much more fiendish. i almost don’t feel anything but a need to take it and more.