☛ Official ☚ The Big & Dandy 5-MeO-DMT Thread - Second Launch

[mr peabody]

Thread 'DMT | +50 articles'

Aug 11, 2021

DMT: Biochemical swiss army knife in neuroinflammation and neuroprotection?*

Attila Szabo, Ede Frecska

The inflammatory theory of many neuropsychiatric illnesses has become an emerging trend in modern medicine. Various immune mechanisms – mainly via the activity of microglia – may contribute to the etiology and symptomatology of diseases, such as schizophrenia, bipolar disorder, depression, or Alzheimer's disease. Unwanted and excess...​

• mr peabody
• Replies: 51
• Forum: Psychedelic Medicine

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[perpetualdawn]

"Neural effects and phenomenology of nondual meditation and 5-MeO-DMT in an expert meditation practitioner"

OSF

osf.io

abstract: https://sciety.org/articles/activity/10.31234/osf.io/whqdp_v2

edit: My synopsis: they gave 5-MeO-DMT to a single *very* experienced (this is an understatement) meditator from a Tibetan buddhist tradition, intranasally, and compared his brain activity to his own non-dual meditation. 5mg resembled it quite closely, 12mg was something else entirely. All were different from baseline.

 

[pupnik]

it is somewhat interesting, but really only one participant, a 57 year old man.
initially they state that the man is an expert meditation with thousands of hours of experience.

I find it difficult to imagine that when he got the low dose 5me0dmt he would not naturally orient his mind similar to how he is during meditation.
Having additional test subjects without meditation experience would clarify that low dose 5meodmt is similar to meditation if it measures out that way.

the larger dose interrupted the meditator's normal approach completely

 

[perpetualdawn]

@pupnik yeah maybe all this shows is how much 5-MeO-DMT it takes to begin knocking someones socks off

 

[pupnik]

@perpetualdawn i think that is true for that particular someone

 

[Didgital]

@pupnik yeah maybe all this shows is how much 5-MeO-DMT it takes to begin knocking someones socks off

I imagine... 12mg is a lot for anyone not familiar.. id like to see how the subject responds after beconing comfortable with the experience.

ummm im a weirdo, but i like to keep a pipe loaded w 5-meo-dmt on bedside table i enjoy the smell tbh

 

[Esperighanto]

5-MeO-DMT is one of the only tryptamines I'm aware of that people frequently talk about which can kill with such an unpredictable nature. I've used it a lot, like way too many times, but it's a drug that I would never really return to. People have given me some wild responses too given my proclivity towards 25X-NBXX's and other things known to exhibit risk, but at least those do so with some degree of a pattern to them.