Opioids MGM 15 Megathread

[noclipuser]

Hello fellow opi heads, with the new banning wave of Kratom and 7OH, MGM-15 has been gaining some attention, especially in the already banned states. From my own experience and the little information available about MGM-15, I call it the methadone of Kratom. It lasts around 10-12 hours instead of 4 hours like 7oh, and is also twice the potency of 7oh. It is also unique in the sense that it is a partial DUAL ACTION agonist. It activates both Mu and Delta opiate receptors. I have been very strict with my use of MGM-15 however, since it also raises tolerance faster than 7oh and has reportedly worse withdrawals than 7oh. People who started using MGM 15 consecutively to replace 7oh had major withdrawal symptoms trying to switch back to 7oh, because 7oh doesn't touch the Delta receptor. I use MGM 15 once or twice a week at most, and continue using 7oh. However, ever since I've tried MGM 15 my 7oh doses became feeling weaker and I'm debating if I should switch to MGM completely. It is sure nice not having to dose three or four times a day or waste as much money, but it is a bit more expensive both financially and has worse withdrawals physically. I also want to sort of gatekeep this analog because I fear it will explode in popularity just like 7oh, and it is ALREADY being sold in some smoke shops under a different sort of branding.

Let me know your opinions/experiences with this novel drug.

 

[TheAcetylationGame]

Hello fellow opi heads, with the new banning wave of Kratom and 7OH, MGM-15 has been gaining some attention, especially in the already banned states. From my own experience and the little information available about MGM-15, I call it the methadone of Kratom. It lasts around 10-12 hours instead of 4 hours like 7oh, and is also twice the potency of 7oh. It is also unique in the sense that it is a partial DUAL ACTION agonist. It activates both Mu and Delta opiate receptors. I have been very strict with my use of MGM-15 however, since it also raises tolerance faster than 7oh and has reportedly worse withdrawals than 7oh. People who started using MGM 15 consecutively to replace 7oh had major withdrawal symptoms trying to switch back to 7oh, because 7oh doesn't touch the Delta receptor. I use MGM 15 once or twice a week at most, and continue using 7oh. However, ever since I've tried MGM 15 my 7oh doses became feeling weaker and I'm debating if I should switch to MGM completely. It is sure nice not having to dose three or four times a day or waste as much money, but it is a bit more expensive both financially and has worse withdrawals physically. I also want to sort of gatekeep this analog because I fear it will explode in popularity just like 7oh, and it is ALREADY being sold in some smoke shops under a different sort of branding.

Let me know your opinions/experiences with this novel drug.

Well if it acts as a delta agonist then it would make sense that people who switch back to 7oh - which in addition to acting as a partial agonist at mu is supposedly an antagonist at delta and kappa - so couldn’t taking a delta antagonist (7oh) when you’ve been dependent on a delta agonist (mgm 15) throw you into the delta equivalent of precipated withdrawals (like from taking buprenorphine while dependent on full mu agonists)? I guess it would depend on their comparative binding affinities..

It is kinda strange to me otherwise why a longer acting opioid would have worse withdrawals if we’re talking equipotent dosages. Usually the severity and duration of withdrawal mimics the pharmacokinetics with the longer acting stuff being smoother to come off but takes way longer.

I’m not from the US and have never even had the opportunity to try either this or 7oh but it always strikes me as completely insane that a government would ban one of the few relatively safe alternatives to a drug they are currently having an apocalyptic epidemic with (fent). Especially after seeing the clusterf_ck that was the forced evolution of synthetic cannabinoids from ‘mostly harmless’ to ‘the new gasoline huffing’

 

[ilikecmyk]

If anyone wants to join the private mgm sub reddit it's r/mgmfifteen or here's a link:

https://www.reddit.com/r/mgmfifteen/s/i0a507TuEY

 

[ilikecmyk]

The sub is a great place to chat with other users as well as have discussions about vendors and various other topics

 

[Kurt Cobain]

The sub is a great place to chat with other users as well as have discussions about vendors and various other topics

Ya issue is the crowd that hangs on the 7oh forums specifically but reddit as a whole. It's a bunch of paranoid know it allsbwho just like to answer their own questions. I apologize for the gross generalization but it's pretty hard with them people frequenting those forums, most of them are actual children and it's sad to see em getting in this deep so quick

 

[Akbill]

I am in a similar situation. I've been a regular 7 user for a while now. I live in a legal state. Recently, I tried some mgm out of curiosity (it's getting popular now that states are restricting 7). I gotta say, mgm is nice. I love it that I can dose twice a day (okay three times), and it provides a nice, even, comfortable experience. I haven't necessarily noticed that 7 doesn't feel as strong, but it does seem to fade faster (maybe just me).

I worry about tolerence and withdrawl too. I could easily see it creeping up and getting out of hand, so I'll be sticking with 7 and only occasionally using the mgm.

 

[Kurt Cobain]

I am in a similar situation. I've been a regular 7 user for a while now. I live in a legal state. Recently, I tried some mgm out of curiosity (it's getting popular now that states are restricting 7). I gotta say, mgm is nice. I love it that I can dose twice a day (okay three times), and it provides a nice, even, comfortable experience. I haven't necessarily noticed that 7 doesn't feel as strong, but it does seem to fade faster (maybe just me).

I worry about tolerence and withdrawl too. I could easily see it creeping up and getting out of hand, so I'll be sticking with 7 and only occasionally using the mgm.

Honestly man the withdrawals get blown out of proportion just like 7oh imo. At my worst I could do just a bit over a gram a day of high purity 7oh powder and the withdrawals while still veru shitty were very manageable with only kratom leaf which might as well not even be taken bc my tolerance is fried permenantly lol mgms withdrawals are a tad worse but honestly people on reddit are just spastic and usually fucking children. Mgm is cheaper, it lasts longer, more manageable and cheaper in the long run and imo while it is stronger it's much less addictive than 7oh bc you don't have thag constant compulsion to redose every 45 minutes and it doesn't leave you with a crack followed by anxiety and exitinal dread I've never gotten from an opioid before

 

[notsmokeymcpot42088]

hows it for pain?

 

[Akbill]

Honestly man the withdrawals get blown out of proportion just like 7oh imo. At my worst I could do just a bit over a gram a day of high purity 7oh powder and the withdrawals while still veru shitty were very manageable with only kratom leaf which might as well not even be taken bc my tolerance is fried permenantly lol mgms withdrawals are a tad worse but honestly people on reddit are just spastic and usually fucking children. Mgm is cheaper, it lasts longer, more manageable and cheaper in the long run and imo while it is stronger it's much less addictive than 7oh bc you don't have thag constant compulsion to redose every 45 minutes and it doesn't leave you with a crack followed by anxiety and exitinal dread I've never gotten from an opioid before

I thought that might be the case. I have experienced withdrawl from 7. Not a walk in the park, but also completely manageable. I've also found ways to keep my tolerance in check (agmatine, NAC). My 7 dose has remained consistent over time. I've learned not to dose compulsively - but mgm was great for that comfortable, warm pain relief that just stretches on and on. I agree that mgm could be cheaper and certainly will be as prices moderate from market pressures. One thing is sure - I will always have mgm around.

 

[notsmokeymcpot42088]

How negative are the effects on your body from consuming this

last thread I saw about it ppl couldnt even decide if it was "Real" or laced with fent......Out of curiosity and bringing an answer to that thread; you fail for fent on a UA if you taking this?

 

[notsmokeymcpot42088]

Ya issue is the crowd that hangs on the 7oh forums specifically but reddit as a whole. It's a bunch of paranoid know it allsbwho just like to answer their own questions. I apologize for the gross generalization but it's pretty hard with them people frequenting those forums, most of them are actual children and it's sad to see em getting in this deep so quick

Real talk never been to the 7 oh forums but oh wow the attitude on redditor drug users is just too much. "Give me a source and ill give you one" proceeds to list source the thread is about --- "Man you fckd me over"

I never said I would trade shit you hit me wth a proposal, a website, than said where can I get xyz --- what you holding out you fucker!!!

Hypothetically -- Google these two words -- "well everyone knows about them" -- GOOD IM OUT.

 

[4DQSAR]

Some halogenated derivatives are VERY potent. I bet anyone £1 that they turn up in kratom products.

 

[notsmokeymcpot42088]

^Nah I dont think I will be taking that bet....

But could I ask you if MGM-15 would trigger a positive on a fentanyl test? (MGM-15 as chemically drawn that is)
As someone on here was claiming they got sent fent instead of/in with MGM-15 based on a "$35 lab test".

They did not really know (nor do I) what metabolites it produces or if it would trigger a false positive on a fent test.
(They seemed pretty secure in the assumption they got shipped 'fent instead of kratom' which shows a fundamental misunderstanding to begin with....none the less)

Some halogenated derivatives are VERY potent. I bet anyone £1 that they turn up in kratom products.

 

[4DQSAR]

MGM-15 itself might best be termed (in a non-IUPAC manner) as dihydro 7-OHM so it's hard to say how presumptive test would fair. I would GUESS that the ELISA tests used to detect fentanyl (since so little might be IN a sample) likely would differentiate.

I suggest that the aryl methyl ether and the tertiary hydroxyl moiety interact as they appear to do in etorphine. Remove that 6-methoxy from etorphine and the result is an activity cliff. From x5000 to around x80 M.

That would explain why MGM-15 is more potent than 7-OHM. That H+ isn't as active if the ring-system acts as an EWG.

Now why an aryl -F increases potency even more is a bit harder to figure out. Is it just space-filling and/or does the halide (being a weak HBA) alter it MORE or indeed both or indeed neither.

Training-sets MAY soon be practical if we can find some more examples. You know, derive 3DQSAR and identify key moieties.

 

[notsmokeymcpot42088]

So in simplest terms if you purchased this you should not pop positive for fentanyl unless it was tainted? -- perhaps synthed wrong

 

[4DQSAR]

So in simplest terms if you purchased this you should not pop positive for fentanyl unless it was tainted? -- perhaps synthed wrong

Well, I would estimate that a presumptive test might pop a false positive, but an ELISA test (which uses an antigen linked to an enzyme) likely would not. Even some compounds far closer to fentanyl will not be detected by the latter.

4-phenylphenapromide, for example. Overlays all of the key moieties of fentanyl BUT steric bulk is significantly different.

 

[notsmokeymcpot42088]

Got ya --- I had to google ELISA test and was still a little unsure if we were just talking about a reagent --- aids kept coming up so I bailed (lol fr though)

So you would agree if you paid someone $35 dollars to see if MGM-15 popped positive for fentanyl --- that person should probably not start accusing the company of shipping fent? (As that is what they were claiming was they plan on here)

 

[ilikecmyk]

I am in a similar situation. I've been a regular 7 user for a while now. I live in a legal state. Recently, I tried some mgm out of curiosity (it's getting popular now that states are restricting 7). I gotta say, mgm is nice. I love it that I can dose twice a day (okay three times), and it provides a nice, even, comfortable experience. I haven't necessarily noticed that 7 doesn't feel as strong, but it does seem to fade faster (maybe just me).

I worry about tolerence and withdrawl too. I could easily see it creeping up and getting out of hand, so I'll be sticking with 7 and only occasionally using the mgm.

If you're on Reddit swing by the mgm sub. It's private: https://www.reddit.com/r/mgmfifteen/s/XfKScYhszq

 

[Kurt Cobain]

Real talk never been to the 7 oh forums but oh wow the attitude on redditor drug users is just too much. "Give me a source and ill give you one" proceeds to list source the thread is about --- "Man you fckd me over"

I never said I would trade shit you hit me wth a proposal, a website, than said where can I get xyz --- what you holding out you fucker!!!

Hypothetically -- Google these two words -- "well everyone knows about them" -- GOOD IM OUT.

It's really sad, so many are clearly kids begging for sources of harder drugs, they're like the fucking seagulls from finding Nemo. So many narcisstic sociopathic ass wipes on reddit so full of themselves it's disgusting like truly disgusting to see and I no joke just seen a few forums on there of them discrediting blue light saying were a trash site to get info from and how reddit is so much better

 

[notsmokeymcpot42088]

If you're on Reddit swing by the mgm sub. It's private: *Deleted out link or itd live on through me*

No. Dont advertise other forums here -- REPORT REPORT -- nah thats a reddit move lol (But go ahead report his shilling ass, second or third one today)

dude is obviously hoping to be OP's plug or w/e and drag any idgets he can with em'. If that is your game GET BETTER AT IT lol