N&PD Moderators: Skorpio Forums Media, Science and Research Neuroscience and Pharmacology Discussion Can someone please explain how trazadone helps combat the effects of stimulants? The pharmacological mechanism. JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding. You are using an out of date browser. It may not display this or other websites correctly.You should upgrade or use an alternative browser. Members who reacted to message #5 All (1) Like (1) Jan 25, 2024 Juicewrldfan Bluelighter Messages 1,551 Reaction score 1,496 Points 70 Loading… Forums Media, Science and Research Neuroscience and Pharmacology Discussion Can someone please explain how trazadone helps combat the effects of stimulants? The pharmacological mechanism.