N&PD Moderators: Skorpio Forums Media, Science and Research Neuroscience and Pharmacology Discussion Removal of the N-cyclopropylmethyl from buprenorphine and replacing it with an N-Me or N-phenethyl would create extremely high potency full agonists. JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding. You are using an out of date browser. It may not display this or other websites correctly.You should upgrade or use an alternative browser. Members who reacted to message #3 All (1) Like (1) P Feb 23, 2022 purplehaze147 Bluelighter Messages 470 Reaction score 92 Points 280 Loading… Forums Media, Science and Research Neuroscience and Pharmacology Discussion Removal of the N-cyclopropylmethyl from buprenorphine and replacing it with an N-Me or N-phenethyl would create extremely high potency full agonists.