N&PD Moderators: Skorpio Forums Media, Science and Research Neuroscience and Pharmacology Discussion Can anyone explain thru what mechanisms can amphetamines lower opioid tolerance JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding. You are using an out of date browser. It may not display this or other websites correctly.You should upgrade or use an alternative browser. Members who reacted to message #8 All (2) Heart (1) Like (1) Nov 21, 2021 simstim Bluelighter Messages 6,601 Reaction score 5,038 Points 0 Nov 20, 2021 DeathIndustrial88 Bluelighter · From The Land Of Nod Messages 3,682 Reaction score 4,565 Points 120 Loading… Loading… Forums Media, Science and Research Neuroscience and Pharmacology Discussion Can anyone explain thru what mechanisms can amphetamines lower opioid tolerance