N&PD Moderators: Skorpio Forums Media, Science and Research Neuroscience and Pharmacology Discussion How come certain drugs (i.e. antidepressants) take days/weeks before they work? JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding. You are using an out of date browser. It may not display this or other websites correctly.You should upgrade or use an alternative browser. Members who reacted to message #4 All (1) Like (1) Nov 20, 2021 Opi_Kid_Rock Bluelighter · From Lost. Always have been it seemed. Messages 937 Reaction score 743 Points 95 Loading… Forums Media, Science and Research Neuroscience and Pharmacology Discussion How come certain drugs (i.e. antidepressants) take days/weeks before they work?