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"CHEMICAL X" thread - mental masturbation for drug SAR geeks

rickolasnice

rickolasnice

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Joined
Apr 19, 2007
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I think it's 4-HO-DMT or relative. Maybe 4-Me-DMT.

131: Hydroxyindole
187: Desmethyl 4-Ho-DMT
175: Didesmethyl 4-Ho-DMT
 
3-(2H-chromen-7-yl)butan-2-amine

Apparently this is being marketed in the UK. I took a stab at drawing it http://imgur.com/Ai9uV

I probably butchered it lol. I could not find any information on it anywhere, even if I was still using substances it doesn't look like something i'd touch. I am just wondering if anyone has any thoughts about this one. I have a few but my level of understanding isn't yet at a level that i'd consider them valid or worth posting.
 
This should be the correct structure.

icmglc.jpg
 
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^^ Thanks, I actually realized that double bond was in error but that particular editor would not let me correctly delete it.

For me the chromone ring was very odd. Im not familiar with many pharmaceuticals containing it. The only thing I can recall learning about similar to it is warfarin. Any particular reason why this would be used?
 
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Most of the major peaks match up to aMT, the massive peak at 131 is a dead ringer for aMT
 
The only psychedelics they compare to are: 5-MeO-DiPT, DOB, PMA, 5-MeO-DALT, 5-MeO-DPT, Bromo-dragonfly, 2C-I ... They need to get with the times! :p
 
That sucks. I just told someone to send in (and I quote) a "Matrix Fury" RC tablet...

How can we get ecstacy data new lab standards...? Like a way to donate specifically for that? This is a huge issue.
 
Lope metabolite a p-glycoprotein inhibitor with high concentrations,is it relevant?

Here's a study where one of loperamides metabolites can act as a P-glycoprotein inhibitor at high concentrations:http://www.ncbi.nlm.nih.gov/pubmed/20212014

I have no idea how to determine plasma concentration from doses of loperamide taken. I was thinking that maybe people that dose loperamide high enough build up enough metabolites to inhibit p-glycoprotein and allow some loperamide into the brain but I can't really interpret the study that well myself so I was hoping somebody in ADD could shed light on it.
 
20 micromolar is a pretty strong concentration. And you'll note that they say that desmethyl loperamide is merely a substrate at most levels. I see no reason that loperamide wouldn't do the same (inhibit PGP by competitive action) at ridiculous concentrations.

0.8 ng/ml is a typical blood level for 4mg of loperamide. That's about 1.5 nanomolar. So extrapolating lineraly you'd need 13,300x the theraputic dose of loperamide before you could expect inhibition at 20 uM. and that's not counting secomnd or third order metabolism/absorbtion/distribution effects.

Loperamide is not a centrally active drug and people shouldn't be figuring out how to make it one.
 
Is it centrally active at high doses. I'm currently on a high dose of loperamide. My pupils are pinpoint, I'm sedated, and I'm experiencing absolutely no WD from 2 mg daily subs I was taking for 3 weeks. It's been 5 days since I dosed subs. I'm not trying to make it centrally active. I'm just trying to figure out why it is active centrally when you take a very high dose. I've taken many many opiates and I can tell the effects I'm experiencing are exactly like other opiates.
 
ferinox said:
Is it centrally active at high doses. I'm currently on a high dose of loperamide. My pupils are pinpoint, I'm sedated, and I'm experiencing absolutely no WD from 2 mg daily subs I was taking for 3 weeks. It's been 5 days since I dosed subs. I'm not trying to make it centrally active. I'm just trying to figure out why it is active centrally when you take a very high dose. I've taken many many opiates and I can tell the effects I'm experiencing are exactly like other opiates.
Click to expand...

Mu receptors are present in the intestinal tract. Loperamide can cause standard peripheral effects of opiates even thought it doesn't pass the BBB. It can also alleviate some of the physical effects of opiate withdrawal. That dose of bupe for only 3 weeks shouldn't really cause terrible withdrawals in the first place.

If a person jams enough imodium down they may very well get a weak buzz. Fortunately the prospect of not being able to shit for a week tends to keep most people from trying.
 
I nodded while I was on 100 mg loperamide before I had an opiate tolerance. Nodding isn't what I call a weak buzz and I don't think peripheral receptors are responsible for nodding. There's been many people who have caught more than a weak buzz on lope including many on these bluelight forums. I prefer talking about loperamide on the opiophile forums because they don't instantly respond with it only effect peripheral receptors. I also shit fine when I take immodium, it's average half life is only 10.5 hours. It only takes me about 36 hours after dosing to shit. The lope buzz isn't that enjoyable, I just took it for it's anti withdrawal effects from the sub. I'm not going to turn an ADD thread into a social thread so this can be closed.
 
Plus, chronically inhibiting p-gp may lead to increased levels of of all kinds of stuff you don't want in the brain...could end up with early onset Alzheimer's.

Really, I don't care how high it gets you...it isn't something you want to mess with on a regular basis.
 
I already said I don't enjoy the lope buzz. It feels toxic. It's great for emergency WD situations but i'm planning on stopping when I have 3 days off in row this week. I don't understand how some people use it for a maintenance drug, it doesn't feel good for you at all.
 
3-[(E)-1-(Benzyloxyimino)ethyl]-2-oxo-2H-chromen-7-yl acetate ?

Hello,

I am new here and would like to ask if anyone has any experience of this which is apparantly a newly available RC and being sold in the UK under a brand name "legal" ? capsule

Thanks, Andy
 
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