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aMT neurotoxic?

bighooter

Bluelighter
Joined
Mar 31, 2008
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1,660
Is aMT neurotoxic?

and if so just how neurotoxic is it compared to other drugs like amphetamine for example.

I'm really considering using aMT for mental healing which no anti depressants or councelling have been able to do.

I'm very experienced in using drugs and 25gs of psiclocybe tempanesis was very very mild for me with no hallucinations what so ever so i'm presuming I have a high tolerance to psychedelics so will be starting off with 50mgs of aMT for my first time.

I am just wondering if there is any research on the toxicity of aMT though and at what dosage this is likely to occur?
 
Theraputic doses of aMT are brilliant, and almost certainly non-toxic.

aMT is likely neurotoxic at very high doses but that's about it.

They used to sell it in the old Soviet Union as an OTC anti-depressant, and only stopped due to it's abuse potential (not any concerns about toxicity IIRC).
 
I can't comment on the neurotoxicity of AMT...but I can give some input about healing properties.

I'm pretty sure I have PTSD, after living two years with the demon-bitch gorgonslut devil spawned housemate from perdition, a series of malicious false arrests that always came to nothing after being strung out on bail for nearly a year, pets killed...I need not say more, but I did a self-report PTSD test from a psych profiling site, and it confirmed what I thought.

Accidentally took way more AMT than I intended, being already dissociated to a degree thanks to methoxetamine, long story short, I ended up railing several large doses of AMT, intending to increase the dose of MXE. The result was an incredibly powerful, cathartic and healing trip. Battered constantly with sensory input, it would not stop for anything, just constantly flooded with thoughts and emotions for probably many hours.

After that I felt....somehow liberated. Took it again at a much lower dose, likely around 10-15-20mg, and went for a long hike in the woods. Its changed several things since I first got aquainted with the drug. That day in the woods, went looking for wild mushrooms to eat, found nothing but a few tawny grisettes (Amanita fulva), a false deathcap and possibly a deathcap. Neither are ones I want to eat, the former just because its not one that appeals to my tastes, the latter, well, its obvious from the name that they are not for cooking and eating.

Ended up using the bags I had with me to clear a massive load of litter and trash from the woods. Made me much more aware of the tiniest details of everything. Very physically relaxing, AMT seems in me to have some sort of powerful muscle relaxant properties. Curled up in a little clearing and just watched the wildlife, and let the AMT work its thing. Went into a charming little spanish tapas bar and the serving lass there went out of her way to give me some fantastic service. People seem to want to help out, or otherwise somehow go out of their way to be good while I am under its influence. Last time, same tapas bar, someone I barely spoke to just waved some money at me and told me I was getting my supper paid for. Complete random person, didn't speak to her, just sat at a close table, this 50-60something lady just randomly decided that I was not going to be paying for my pints and my calamari.

Every time I do AMT, there is a very pronounced afterglow, that lasts quite some time. No comedowns as yet. It opens up a psychological state where I am able to work through my issues. Sometimes it almost appears like these psychological troubles get worked through for me, without my conscious input, by my subconscious. The drug itself fixes nothing, it just opens up that place within a person where they themselves can achieve these things without any psychological blocks or subconscious shutting down.

I'm just waiting for my damned course of metronidazole to be over. Last couple of tablets of the bloody stuff, then a 48 hour washout period. Very likely that metronidazole, aside from the possible alcohol reaction (off topic, but I accidentally, in a moment of extreme stress, after some shite really hit the fan one night, necked a pint of beer that was pretty much put in front of me, then thought 'oh..BUGGER! I've gone and poisoned myself', but no disulfiram/coprine type reaction at all) appears to have some sort of serotonergic properties and has been implicated in fatal serotonin syndrome. Then I'm off to the woods again, to do some more personal work.

Afterglow lasts many days, couldn't say how long, but a good while, leaves me clear-headed, with no PTSD hyperarousal, seems to have long lasting and strong anxiolytic effects, stronger I would say than benzos, which merely numb a person to their fears and stresses.

Not a drug to be abused, and certainly I would NOT reccomend it for a club, for those people who are so inclined, I always take a full dose of aspirin, and a glass of effervescent magnesium sulfate antacid product, the former because AMT appears to raise body temperature quite significantly, its a very weak MAOI I believe, and this is probably the reason, in combination with a serotonin releaser, with dancing and in a club I think it may well be dangerous. The MgSO4 is to eliminate the slight jaw tension, no gurning, but definately wide eyed and with some jaw tension. Oddly, I very much like AMT, but I really do not care for MDxx and its ilk. I'm autie, and MDxx induced openness and people-inclination, thats just not my classically autistic self and it feels fake. AMT feels totally natural to my psyche. Definately going to be a long term ally. Just like Shulgin and Shulgin, and their 2C-B and MDMA, that is the position AMT now has for me. Its helped me heal wounds I never thought I would have a chance to. That job isn't finished yet but there is much progress.

Just don't abuse this drug, I believe in an abusive context the consequences may prove severe.
 
Theraputic doses of aMT are brilliant, and almost certainly non-toxic.

aMT is likely neurotoxic at very high doses but that's about it.

They used to sell it in the old Soviet Union as an OTC anti-depressant, and only stopped due to it's abuse potential (not any concerns about toxicity IIRC).


If only I lived in the soviet union during this time.
le sigh.
 
Did people abuse aMT in the Soviet Union? I was under the impression that abusing psychedelics was something rather few people would chose to do if given the option.
 
they will abuse ANYTHING over there. Look up 'krokodil' if you have a strong stomach. Its a noxious mixture of some desomorphine, a load of byproducts, red phosphorus, and I think, possibly some sort of cleaning product. They are actually SHOOTING this stuff IV. There are some video clips of an interview with a user out there. And this girl, you can actually see the bones in her arm exposed, where all the flesh from forearm to elbow has become necrotic and rotted away.

Also, they abuse via IV, 'coaxil', shooting megadoses of tianeptine.
 
Just looked into Krokodil
man that's just sad and disgusting.

Anyone who would shoot up a drug knowing that their life expectancy is now limited to one year is clearly a moron.
 
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Yes, I would say 'moron' just about covers it. A bit insulting to morons the world over, but hey, I couldn't give a shit about 'em, there are way too many still alive:P
 
actually I agree,
that's insulting to morons, dumbasses, and dipshits around the world.

I need to create a new word for people dumb enough to shoot up krokodil
maybe Fucktard would work, but I still feel like that's too good for them :/

What I don't get is why don't they further refine thier product so the toxicity is not as bad?
Sure it might cost a few more bucks, but is that not fucking worth it?
It's like a DMT dealer selling you lye with a flake of dmt on it.
 
αMT's analogue αET has been shown to produce long-lasting serotonergic neurotoxicity at very high doses,[6] and the same likely holds true for αMT as well, though no studies have been performed to verify this as of yet. However, based on anecdotal reports, both αMT and αET appear to produce considerably less of a hangover in comparison to MDMA, although this is not necessarily an indication of long-term safety

Quote directly from Wikipedia.


The only danger i have ever seen with AMT so far is a trip report of a user who was on antibiotics and took AMT.
 
I'm guessing that the side effects from aMT don't include rotting of the flesh. Ugh lol, I really want to try this chemical, especially after reading your experiences, Limpet_Chicken.

I too have some anxiety problems that I would like to work through and have been looking for therapeutic psychedelics I haven't tried.
 
Just looked into Krokodil
man that's just sad and disgusting.

Anyone who would shoot up a drug knowing that their life expectancy is now limited to one year is clearly a moron.

To be fair, addiction makes people behave in irrational ways, and prohibition creates fertile ground for dangerously impure drugs.

But not what this thread is about really, sorry. aMT is great.
 
I wouldn't say the fact that it was sold in the Soviet Union long ago is any indication of its safety. We're talking about Russia decades ago, during a time when the US FDA was releasing its own share of drugs now known to be unsafe. The posted report of aET's toxicity is a better guide, I think.

There's a fairly widely subscribed to theory that says anytime serontonin and dopamine are released at the same time (MDMA, aMT, aET, meth, and likely: mephedrone, 6-apb, and a host of other triple monoamine releasers) neurotoxicity results, though I don't remember why exactly. I personally have used aMT quite a bit, with the only result being brain zaps (occurs with overuse of most serotonin releasers and serotonin reuptake inhibitors). But I use it in moderation. From what I've read about the neurotoxicity of monoamine releasers, the trend seems to be that high doses and frequent redosing results in disproportionate amounts of damage compared to what might be expected from adding up the damage of single doses separated by substantial intervals (I am far from an expert, though). It takes around 2 months to completely recover your serotonin from a single use of MDMA. As aMT works similarly it would be wise to treat dosing frequency with it similarly (my unsubstantiated feeling is that young people can probably get away with using a strong releaser maybe once a month without much damage).
 
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Heh, never suggested it was comparable to banging krokodil.

Doesn't mean its devoid of serotonergic neurotoxicity (AMT), but I have never noticed any hangover or crash from AMT. Exactly the opposite. I always feel really well rested and full of energy the day after. I have felt very tired at the end of a day if I've dosed AMT, but I put that down to the fact that many of those times, I had started the day that way, and hiked through the woods for a long, long time, going out at around 12, and not coming back until midnight, eating very little all that time (it has anorectic properties, at least in me personally, which make me think it is indeed a dopaminergic drug in addition to serotonin release and likely reuptake inhibition) No surprise I was tired after that, especially having consumed a quantity of alcohol just prior to returning, in a small bar, several double shots of tia maria in black coffee (try it, on AMT, make sure its real coffee, not that filthy instant shite, a real treat for the senses)

I have noticed that there is a complete lack of adrenergic stimulant tweaky push to it, I really don't like that in a drug, its enough to make me want little to do with stimulants that are not quite selective DARIs.

If a large part of the 2-day post ingestion depressive and generally miserable effects of MDxx are due to the long lasting inhibition of tryptophan hydroxylase, and I think it likely, I've noticed absolutely none of that tendency with AMT.

After what was said about antibiotics, I should back that up some.......metronidazole in particular is very likely to be DANGEROUS, as it has been implicated in serotonin syndrome! I'm just waiting for a washout period now of metronidazole from my system, wanted to take AMT again, but I can't now until its all been excreted.
 
My sincere apologies. I was under the mistaken impression that krokodil was in use during late soviet times, when everything was starting to fail, which would have made it's use a bit more understandable (people in desperate times wouldn't care as much about their long term health).
 
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Consider that it was in use in the soviet union, which was hardly a model of a prosperous or happy society (worse in some times than in others, but at it's worst, it made ghettos in the US look like a great place to live). Food (and everything else) shortages, oppressive govt, constant fear of the secret police dragging friends off, surrounded by soviet era architecture (big grey concrete boxes)? I suspect that the people who were turning to it didn't much care whether they lived or died.

Are you serious?

Have you ever been out of your own 'happy and prosperous' country?

I suspect the women took the aMT back to their caves whilst the men were out hunting for dinner...
 
aMT does have a lingering emotional edge for a couple of days afterwards. this is felt to varying extents with most serotonin releasers (mephedrone, methylone, 4FA, MDA, 6APB) MDMA being the most debilitating i have yet experienced.
 
1st time poster - don't shoot, cheers. To OP - aMT felt neurotoxic to me if my own perceptions of a drug's pharmacology while shitfaced are relevant and it felt like nasty shit. aMT freebase 250mg bought with some benzo fury for the wife (100mg pellet). I eat what was around 50mg and smoked around 10mg on the end of a fag (must get some scales, i know, irresponsible etc) and had horrendous headaches 2 hrs in and completely, cricket bat round the head fucked for a week after. Also some respiratory depression tho that could have catalysed by the 200mg tramadol a couple of hours earlier. Couldnt sleep til T+17h.

Didn't get the psychedelic side of it really, just some shitty side effects on what felt like fairly important parts of my body. Wife (who is a Brighton and Hove Albion level) user said she had a wicked time on the 6-apb and I'm going to to try that shortly. Definition of love, after this experience I would say is giving your girl the 6-apb while you take the crazy lung burning Russian shit!

Not a deep analysis i know - just my 2p worth (any advance on 2p?) that aMT is horrible shit.
 
Consider that it was in use in the soviet union

Get your facts straight. Krokodil abuse has been around for about five years, the Soviet Union fell twenty years ago.

Edit: Sorry to derail the topic, I've got nothing to add on the discusssion of aMT-neurotoxicity, have yet to make acquaintances with this chemical.
 
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