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So Who Likes Benzos? Ver III: Blackouts and Amnesia

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Mr Blonde said:
....Perhaps maybe do a little experiment with diazepam to see where my tolerance is sitting. ;)
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Yeah done that before....cut to an hour or two later and the "experiment" has turned into a binge! >_< lol. Goodluck though man! :)

Tripman said:
....150mg valium.....
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Jebus!! 8( (obviously dependant on availability) would it not be better to dose with liq if these quantities of diaze are needed? Just a thought. :)
 
tyrael said:
Yeah done that before....cut to an hour or two later and the "experiment" has turned into a binge! >_< lol. Goodluck though man! :)



Jebus!! 8( (obviously dependant on availability) would it not be better to dose with liq if these quantities of diaze are needed? Just a thought. :)
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I had 80mg Liq IV'd did nothing. Warmed my face a little...

No real anxiolytic properties.
 
The-Future I would suggest that mixing benzo's and alcohol is best avoided, particulalrly is one is not quite tolerant to either or both drugs, if you must do it then use very low doses of each and titrate your alcohol dose slowly. I don't think the combination is overly likely to cause death unless you go way overboard but it would certainly be more dangerous than either drug on its own.

The main issue is that you often will black out and act very out of character and often very inappropriately, generally with no recollection of the antics afterward, during this period aside from the problems you can make for yourself and others you are also more likely to get into a stupid accident and hurt yourself because you seldom realise that you are half as intoxicated as you are.
 
Very good advice (of course! :)) d_m! =D

Maybe we should open another thread for Tripman? :P Maybe by doing the opposite of what d_m is saying may be you Tripman :P
 
drug_mentor said:
The-Future I would suggest that mixing benzo's and alcohol is best avoided, particulalrly is one is not quite tolerant to either or both drugs, if you must do it then use very low doses of each and titrate your alcohol dose slowly. I don't think the combination is overly likely to cause death unless you go way overboard but it would certainly be more dangerous than either drug on its own.
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I imagine one of the biggest risks would be aspirating ones own vomit while passed out (or, as you said, doing something stupid and dangerous)
 
I'm currently on 200mg diazepam, around 30mg estazolam and a full bottle of wine and i'm manic...

I think we need to teach me how to NOT be manic, maybe some stilnox. I have plenty.
 
Seriously?! And I know you (of all people) don't actually need to be told and it's off-topic for this thread, but if your prescribed Tx is in these quantities, maybe it's time for a re-evaluation of your Tx!? Don't ya think? :\
 
I'm going into de-tox for benzo's today. So it was a last goodbye. Didn't do anything anyway, I took two 12.5mg CR ambien and got 4 hours sleep now here I am again...

The detox is gonna be 10 days with the idea of dropping me down to 20mg diaz a day I think... I'm gonna push for 2mg clonazepam so at least it lasts a bit longer.
 
I don't know if this belongs here but I didn't want to start a new thread about it;
I am on an SNRI (pristiq) 50mg and on the weekend I took 1mg of xanax with an oxy 20, and had a beer or 2. I felt good for a while but then got a mad headache, a lot more painful than the average headache I experience. I understand its probably not good to mix these drugs while on an SNRI, but these were all lower doses than I have done before. So I'm wondering was this like seratonin syndrome from the oxy + pristiq? I probably won't attempt to mix these drugs anymore while on pristiq (maybe just stick to the loyal xanax).
Thanks
 
redsweater said:
I am on an SNRI (pristiq) 50mg and on the weekend I took 1mg of xanax with an oxy 20, and had a beer or 2. I felt good for a while but then got a mad headache, a lot more painful than the average headache I experience. I understand its probably not good to mix these drugs while on an SNRI, but these were all lower doses than I have done before. So I'm wondering was this like seratonin syndrome from the oxy + pristiq? I probably won't attempt to mix these drugs anymore while on pristiq (maybe just stick to the loyal xanax).
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Could have been a sign of mild serotonin syndrome. Oxycodone is contraindicated with the use of serotonin reuptake inhibitors because it can lead to serotonin syndrome, through some unknown mechanism. If you are going to try this again in future, it might be a good idea to keep some Periactin (cyproheptadine) on hand. It is an over the counter (S3) antihistamine that has serotonin antagonistic properties and is used in serotonin syndrome as a treatment. I would even dose the Periactin at 12mg-16mg before hand, and it will also add the benefits that having an antihistamine with an opioid does anyway.

Tripman said:
I'm going into de-tox for benzo's today. So it was a last goodbye. Didn't do anything anyway, I took two 12.5mg CR ambien and got 4 hours sleep now here I am again...

The detox is gonna be 10 days with the idea of dropping me down to 20mg diaz a day I think... I'm gonna push for 2mg clonazepam so at least it lasts a bit longer.
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Good luck comrade. I went into detox for one day before deciding it wasn't for me and leaving. It was boring as hell, and they confiscated my fucking books because they were medical texts that mentioned drugs. That left me with nothing to do but listen to people sharing junkie war stories all day, something not conducive to me getting better and plus I have the means to self-medicate at home.

It's probably too late for you to read this message now, but I hope it works out better in there for you then it did for me. :\
 
Mr Blonde said:
Oxycodone is contraindicated with the use of serotonin reuptake inhibitors because it can lead to serotonin syndrome, through some unknown mechanism.
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Interesting, I didn't know this (checks out though ;)). Any idea how common it might be? I suspect quite rare as AMH doesn't even mention it
 
^ Probably uncommon, here is the information from the Drugs Interaction Checker:

Interactions between your selected drugs

oxycodone ↔ desvenlafaxine
Applies to: oxycodone, Pristiq (desvenlafaxine)
MONITOR: Coadministration of oxycodone with serotonin reuptake inhibitors has been associated with development of the serotonin syndrome. The mechanism of interaction is unknown. Unlike other analgesics such as phenylpiperidine opioids (e.g., meperidine) and tramadol, oxycodone is not known to possess serotonergic activity and has not previously been associated with the serotonin syndrome. The report describes a bone marrow transplant patient who developed severe tremors and visual hallucinations after he dramatically increased his dosage of oxycodone while on a stable dosage of sertraline and cyclosporine. Discontinuation of cyclosporine did not completely resolve his hallucinations and had no effect on the tremors after 72 hours, which led to consideration of a possible sertraline-oxycodone interaction. The patient's symptoms resolved after sertraline was withheld and cyproheptadine (a central serotonin antagonist) administered. Serotonin syndrome is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea.

MANAGEMENT: Until more data are available, caution is advised if oxycodone is prescribed in combination with serotonin reuptake inhibitors, particularly in complicated patients such as transplant patients who are also receiving cyclosporine. Patients should be monitored for symptoms of the serotonin syndrome during treatment. Particular caution is advised when increasing the dosages of these agents. If serotonin syndrome develops or is suspected during the course of therapy, all serotonergic agents should be discontinued immediately and supportive care rendered as necessary. Moderately ill patients may also benefit from the administration of a serotonin antagonist (e.g., cyproheptadine, chlorpromazine). Severe cases should be managed under consultation with a toxicologist and may require sedation, neuromuscular paralysis, intubation, and mechanical ventilation in addition to the other measures. Patients should also be advised of potentially additive central nervous system effects from these agents and to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them.
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There is no other information on when this case occurred or if others have, so I might dig around a bit later to see if I can pull up some more data. Cyclosporine is an immunosuppressant drug, and so is unlikely to have contributed to the formation of serotonin syndrome in this case as they pointed out by removal of the cyclosporine first.
 
i asked my mate who studies pharmacology and all that stuff and he reckons it could have just been a headache made worse by mixing those drugs but doubts it was seratonin syndrome. phew ;)

stayed up til 4am weds night then got up at 7 for a surf, got back at 11 and mixed in 3mg of xanax with a cup of coffee. thought i would be aight but guess the lack of sleep + exercise got to me, literally got floored (fell asleep on a rug), family tried to wake me but apparently i wouldn't move, woke up about 20 hours later with a very sore back D:
 
^ Yeah one of the symptoms of overdoing opioids can be a headache, I've gotten that before from too much morphine. Glad it wasn't serotonin syndrome. :)
 
^ Ah! So thats why I've been getting headaches on occasion. Didn't make a lot of sense when I was getting headaches while taking(overdoing) painkillers :|
 
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