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cannabis thc marijuana withdrawal & nmda agonist

emkee_reinvented

emkee_reinvented

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All my previous attemps failed me caving in on day 4 mostly due to stress. Situation little kid pregnant wife made the attemps futile.

So this time I prepared a plan, because my withdrawal is pretty extreme. Besides the fysical effects that are annoying its the mental part that is really problematic. And i have to be functional as life goes one.
So i bought some Kratom and some Methoxetamine and have Pregabalin. The idea was to rotate these meds so Kratom on day 1, Methoxetamine day 2 and Lyrica day 3. With some crossover here and there.

The Methoxetamine, that I never tried before, was a glowing experience. I had a trip on it that was pretty intense considering the low dose. Felt more sedating then Ketamine and with differences in the way it opened insights. I was in my mothers house and the squareness of everything was annoying me. Advice make you house more organic or go outside. All in all it was very rewarding and strenghtening experience.

But the point after my trip on Methoxetamine I really was free of the cannabis withdrawal syptoms temporarely. Logically when your high as a kite. So I started searching and found this paper about nmda-agonists and cannabis addiction.
http://www.temple.edu/pharmacy/directory/files/raffa_pdf_PBB8649907.pdf

So my question will methoxetamine have this effect and at what dosage. Is a trip needed or do low dosages work just as welI and how long will it work, At what intervals should it be taken, daily seems risky. Offcourse i will be kind of a labrat experimenting on myself but i found during my trip i was acting weird which cannot be combined with family life. So a lower dosage would be more suitable.

guessing this is day 5 of my cannabis withdrawal, my memory is kinda impaired. I will keep rotating the meds. And have no fear about getting addicted to any of these 3, as i have found my DOC is cannabis. My extensive experience with Kratom, Ketamine and Pregabalin never resulted in addiction problems. Although Kratom for me can be habit forming breaking the cycle never gave any problems like Marijuana withdrawal.

So fellow addicts an wise men wish me luck & strenght, greetings to you all day 6 is nearing
 
I went cold turkey off a 300+mg oxycotin daily habit. Now that was a toughie to quit. I never have found cannabis to be a drug I needed to taper off of, or had dramatic trouble quitting.

Check out our quitting mega thread.
 
If you really feel NMDA antagonists will help, don't introduce another drug addiction. Magnesium citrate/glycinate and Zinc are potent nmda antagonists, and they will help immensely with your every day life.
 
don't cry for marijuana. the withdrawals are nothing compared to opiates and benzos, and even caffeine has worse w/d's than weed in my opinion.

take some melatonin at night to sleep and exercise
 
adjunct

thanks today i feel real "good" i think i ll stop rotating. yesterday i was on pregabalin 450 mg that really effects your judgement, and your writings.

I experienced absolutly no withdrawal effects from Kratom or Pregabalin in the past when tapered correctly. But Marijuana i blazed for 22 years so maybe that has something to do with it? And Mari-Jane is absolutely untaperable for me.

the study points out some good effects of nmda antagonists have on addiction by disrupting the glutaminergic system. that is probably only part of the withdrawal system, but overexcited glutamine neurotransmission never feels good (think alcohol withdrawal). But today i dont feel like crying and i am not an angry men. So my withdrawal doesn t resemble my previous attempts without Methoxetamine. So today i gonna be (mostly) sober, because as pointed out marijuana withdrawal is a bitch, but not like opiods or benzos! I am not gonna switch addictions

The suggestion Magnesium and Zinc I take, any info on dosages. My multi contains 10 mg zink Zinc picolinate and ZMA per pill. Gonna get some Magnesium for sure as adjunct to my supplement regime which was on my mind for a long time. Great for ADD-ers too as Magnesium prevents dextro-amphetamine tolerance ed, which is the only drug I am on now (prescribed) and has relaxing capacities. Maybe stopping my teeth grinding? my->my daughter wants this on placed 8(
 
I've used jwh-250 to quit marijuana; quite effective, no withdrawals noted whatsoever. j/k lol but this did work for me; I don't get withdrawal from either though (7 years of daily use, mostly at night). Pregabalin and kratom have a worse withdrawal; MXE seems like overkill to me but whatever works.
 
When my mood hits rock bottom i will def check the quitting thread. But for now I seem miraculasly free of symptoms, except for my mouth which keeps on talking blablabla.... etc. Luckily I have melatonin 5 mg, which is prescription only here, as the vitamin stores are allowed to sell 0.2mg tabs max. so will start taking it again. Any info at what dosage magnesium and zinc should be taken?

not want to start a yes/ no discussion, but for my personal constitution, thc has withdrawal symptoms were way worse then Kratom or Pregabalin (which I tapered). Probably caused by the lenght of time I used Cannabis, maybe if I had been on Kratom or Pregabalin for 22 years my opinion would be different. Benzos I can t even imagine getting addicted to it as they make me feel like shit. Blunted sedation is not my thing.
 
To robottripping

That was an idea I contemplated but disregarded. How did you use JWH-250 dosage, ROA. Did you choose JWH-250 cause it seemed like the best choice out of the syntetic cannabinoids to use as substitute. I have no experience or knowledge concerning these substances and I honestly didn t consider them usefull as withdrawal tools.

Although oral thc did lessen the withdrawal in experiments i did not help me. Earlier attempts included oral thc but the results were minimal at best. Relapse always happened using this method, but my situation is like I explained demanding me being there in the family life. But al goes well this time suprisingly :)
 
Chainer said:
I went cold turkey off a 300+mg oxycotin daily habit. Now that was a toughie to quit. I never have found cannabis to be a drug I needed to taper off of, or had dramatic trouble quitting.

Check out our quitting mega thread.
Click to expand...

Personally tapering seems logical with the combination of a drug that causes tolerance and a user that keeps raising there dose. And the extremity of withdrawal like with opiods or benzos with the latter even being lethal. But totally unlike cannabis which causes no tolerance as my dosage never got higher but lower over time, and with the withdrawal symptoms being less severe.

Although i imagine one could taper with willpower (no option for me). I wonder if tapering could be helpfull my feeling says no but i could be wrong. Changing ROA is researched and looks like oral thc could be helpfull (again not with me)
 
laCster said:
don't cry for marijuana. the withdrawals are nothing compared to opiates and benzos, and even caffeine has worse w/d's than weed in my opinion.

take some melatonin at night to sleep and exercise
Click to expand...

Euh? Caffein withdrawal worse then Cannabis withdrawal your chemistry is different then mine but this seems highly unlightly for the majority of people. But Melatonin is certainly useful although yesterday it wasn t needed as i was sedated from Pregabalin. For the other 2, opoids and benzos, i will take your word that they are worse. One of the advantages of reading bluelight is the harm reduction of knowledge. So no hair on my head will think about taking these 2 lightly. I never use true opoids and my benzo use is mini minimal.

But I will state here that Mari-Jane although labeled soft drug does have withdrawal and can lead to troubles. A friend had to go thru a detox in a psychiatric clinic between all hardcore heroin etc junks to get of Cannabis. Maybe the fact that Cannabis can be bought semi-legal on daily basis, makes it eassier to never skip a day.
 
emkee_reinvented said:
The suggestion Magnesium and Zinc I take, any info on dosages. My multi contains 10 mg zink Zinc picolinate and ZMA per pill. Gonna get some Magnesium for sure as adjunct to my supplement regime which was on my mind for a long time. Great for ADD-ers too as Magnesium prevents dextro-amphetamine tolerance ed, which is the only drug I am on now (prescribed) and has relaxing capacities. Maybe stopping my teeth grinding? my->my daughter wants this on placed 8(
Click to expand...

I take 50-100mg Zinc and 400mg Chelated Magnesium 30 minutes before opiates for tolerance, and 200mg Chelated Magnesium (with a meal) 30 minutes after dosing. I then take 100-200mg Chelated Mg with meals over the course of the day, not exceeding 600mg-800mg/day. Make sure to get a small dose (~300mg) Calcium to offset the NMDA antagonism a bit. 2:1 Calcium:Magnesium ratios is the official recommendation, but I'm not sure if that's the best to stave off Mg deficiency.

I had functional Mg deficiency for a few years from too much Calcium, and it sucked. The messed up thing was I was taking Magnesium Oxide, thinking it was helping, but when I doubled and tripled the dosage (800mg-1200mg), and it still didn't help with muscle spasms, I knew something was up.

Caution is advised with Zinc supplementation: high doses (50-100mg/day) for a few weeks can affect the way copper is absorbed in the GI tract, so careful taking it more than a couple days in a row, unless you supplement with Copper to help out.
 
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RobotRipping said:
Pregabalin and kratom have a worse withdrawal
Click to expand...

I've been taking gabapentin and lyrica for years now, stopping every few months. I've never noticed -any- w/d symptoms besides slight mood drop, but that's due to pregabalin helping to produce more chemicals in the mesolimbic system. FYI, I take it for nerve damage and pain, post surgery or procedures; I'm currently on 500mg lyrica daily, started on 100mg years ago.

It helped a little bit for opiate w/d, but for cannabis w/d symptoms, it's only going to get you high-ish, disoriented, and help you sleep. I can think of no reason I would suggest pregabalin to help quit smoking, unless you've got nerve pain that cannabis was relieving.
 
^ not saying lyrica will give you terrible withdrawals or anything but some people have w/d from it, just as some people have w/d from cannabis and others don't.

Withdrawal symptoms include restlessness, insomnia, and anxiety.
Click to expand...

http://en.wikipedia.org/wiki/Pregabalin

It's not unheard of anyway; neither is cannabis withdrawal. I shouldn't have ranked them as worse than the other, I think there are too many individual factors to consider. I'm really anxious and on edge all the time so going through pregabalin w/d would be far worse for me than going through cannabinoid w/d (whether synthetic or just cannabis).

To the OP: JWH-250 is pretty smooth and cannabis like, so very easy transition for me, it's also pretty strong with the right dose but it doesn't last that long. I wouldn't recommend it to quit, as you'll likely just end up smoking synthetics instead lol. If i were still smoking jwh-210 every day I'd find it much more difficult to quit as it gets me very high, 250 is pretty light in comparison and my doses are low (I smoke 4-5mg per day at most) so quitting is not painful for me at least. I doubt this would work for everyone, as i don't get withdrawal effects from cannabis either.

I think it's easiest just to quit cannabis, deal with the physical symptoms using benadryl/gravol/melatonin rather than substituting another drug in there (MXE could easily become your new drug of choice).
 
With the use of JWH-018, -081, -073, and -250 mixed up, I quit smoking cannabis for about 5-6 months, and eventually stopped smoking synthetics near the end. I went back to my stoner ways, though.

Robot, I shouldn't have implied that nobody will get w/ds from pregabalin, but one of the reasons it is so accessible is that it is viewed as "not abusable" (it totally is), nearly impossible to OD on, and is not habit forming. I've heard that from several doctors here in the US, around the country. I mostly agree, any symptoms I experienced when not using lyrica or gabapentin were so minor I barely noticed. The bump in insomnia and anxiety makes sense, as pregabalin can be used to treat both of those conditions.

Anyway, I agree with what you're saying, just thought I would weigh in with some personal experiences. I still stand by there is no reason to use lyrica or gabapentin while trying to quit cannabis, either make a taper plan or quit cold turkey, it's mostly a mental battle.
 
to chainer: You re right there is no technical reason, more like a band aid or temporarly substitution. Like benzo s have no reason to help quit opiods.


but like I wrote my personality ain t that addiction sensitive and my family life requires some tranquility. I asked my homedocter to prescribe it to me for GAD (generalized anxiety disorder) when i was well into my burn out a long time ago, and am using up leftovers.
 
RobotRipping said:
benadryl/gravol/melatonin rather than substituting another drug in there (MXE could easily become your new drug of choice).
Click to expand...

1-st three are presciption only here and dr-s are reluctant to prescribe anything and very uneducated which makes me more and more hesistant to go via that route. Nothing will ever replace Cannabis as my DOC, like stated 22-years experience. I do feel a warning from you as MXE could
1. lower your judgement while high and relapse
2. sustaining getting high to eventually fall back to DOC
3. getting 2 addictions
4. trading addictions
But i am aware, and all concerns made me more aware as they do hold solid ground. Thanks!
 
Chainer said:
either make a taper plan or quit cold turkey, it's mostly a mental battle.
Click to expand...

Been there several times didn t work for me, although reducing the ammount of times smoking from 6+ to 3/4 did help. And although my plan seems like a draconiun measure which I wouldn t advice for anyone on their 1/2/3 or 4-rd attempt. And i would have rather had a good medical solution like Lofexidine/ sublingual thc-oil and Lithium-orotate guided by a dr with some experience. But that s just something not available.
 
ErgicMergic said:
If you really feel NMDA antagonists will help, don't introduce another drug addiction. Magnesium citrate/glycinate and Zinc are potent nmda antagonists, and they will help immensely with your every day life.
Click to expand...

You re worries are taken seriously I am taking my 2-nd day sober and 9 days free of THC. I do wonder if magnesium and zinc are just as usefull as ketamine/ Dxm/ Methoxetamine as nmda-antagonists. But for now it seems to have worked for me although by no means a magical solution, it did require willpower determination and I believe the substitutes worked somewhat.

About Methoxetamine, who knows, but the day after use it did seem to lessen my withdrawal lessening the 2-nd day.
 
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