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Nexium (esomeprazole) as a codeine potentiator

footscrazy

footscrazy

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Psilo was recently prescribed nexium for gastric reflux. Since it helps prevent stomach ulcers caused by NSAIDs, we've been using it before drinking cdubs, and it seems to be a great potentiator too. I'm assuming this is because it reduces the acidity in the stomach, leading to more of the codeine being absorbed. I know that codeine is absorbed best in a less acidic environment, which is why antacids such as mylanta are listed as potentiators. I've never seen nexium being suggested though. Does anyone else have any experience with this?
 
Yeah dude.

Omeprazole/Esomeprazole/Cimetidine work wonders when potentiating the effects of benzodiazepines/opiates.
 
Yep anything that's absorbed better in a less acidic environment should be potentiated by PPIs (such as nexium/esomeprazole) or H2-antagonists (such as cimetidine mentioned above). They're both essentially more potent antacids :)
 
Hopefully I come across this stuff at some point and get an oppurtunity to try it. Aside from the potentiation benefits, I recently used CWE for the first time in months and ended up going a few days in a row. After I stopped I had pretty bad gastric reflux symptoms for a day or two, it may not of been the codeine as I do get gastric reflux semi regularly but given that I used to get it real bad in the days I hammered CWE I have a feeling it was that causing it, it would be good to take a med like this because then it would reduce the odds of experiencing gastric reflux the next day, which has been a contributing factor in my tendency to use oxy and heroin when I need an opioid fix in the last few months or so.

What kind of doses are you using of this stuff and to what extent do you feel it potentiates codeine? Also when do you take it in relation to dosing your CWE?
 
We've been taking 40mg at the same time as the other codeine potentiators, so say 30mins beforehand. The usual dose of nexium is apparently 20mg, but they come in 40mg tablets. It's hard to quantify to what extent it potentiates, from our experience though Psilo felt effects from 10mg valium that he thought was equal to a dose of 20mg for him. With the codeine, I've used smack and/or oxy for about 5 days straight and in the past couple of days have been trying to wean down on codeine and with the nexium, I'm getting a good high from 400mg codeine, which considering my tolerance should have risen quite a bit over the past week, is pretty good. It's hard for me to say though because as you know by some stroke of luck I always get great effects from codeine. Psilo though had pretty much given up on codeine as he wasn't feeling much from 800mg doses; he's taken nexium before 15 tabs of panafen, so 192mg of codeine the past couple of days, and has been getting high off it. I'm seeing it as pretty much a wonder drug lately! Definitely seems to be a much better potentiator than travacalm and dxm.

Does anyone know whether it would potentiate other opiates...?
 
Thanks for giving up my new found potentiator bub :p

It definitely potentiates codeine and benzo's for me. As stated above, I have felt next to nothing from very large doses of codeine. I'm not a daily user like footsy and it astounds me that she can get decent effects from daily use of codeine. I haven't felt much from 1 pack of codeine, even when I first started cwe's. It's not that my liver lacks the enzymes that convert it to morphine (and some other opiates in certain people). I have definitely gotten very high from 2 pack cwe's but, the good sessions are few and far between.

It surprised me that I got any effect at all from extracting 15 tabs (12.8mg codeine/200mg ibuprofen) yesterday. It can only be put down to my use of nexium.

I doubt many docs know about it's potentiating effects. My doc came across as fairly clued on but, he must have no idea about this drugs potentiating effects on both opi's and benzo's or else he would never prescribed me 50 5mg vals with nexium (valium 4x5mg daily).

I'm interested in experimenting with nexium and other oral opi's. Oxycodone already has a very high oral BA (above 80% ), unlike oral morphine which is eliminated quickly by first pass metabolism and this leads to an oral BA of less than 30%.

Some more experimentation is in the pipeline...
 
So it worth just taking mylanta 30mins or so before a codeine session?
 
pinkanga said:
So it worth just taking mylanta 30mins or so before a codeine session?
Click to expand...

Any substance that lowers the level of acidity in the stomach (antacid) will help you to absorb more codeine. That said, I haven't found over the counter antacids anywhere near as effective as the prescription only meds such as nexium. I have used mylanta without any noticeable increase in effects from codeine. It has been a while since I used mylanta to try to increase the absorption of codeine so I may try it again soon to get some kind of comparison.
 
So presumably drinking milk with your cwe (or codeine pills) might have some benefit? (if only marginal).
 
PsiloSubNaut said:
Any substance that lowers the level of acidity in the stomach (antacid) will help you to absorb more codeine. That said, I haven't found over the counter antacids anywhere near as effective as the prescription only meds such as nexium. I have used mylanta without any noticeable increase in effects from codeine. It has been a while since I used mylanta to try to increase the absorption of codeine so I may try it again soon to get some kind of comparison.
Click to expand...

I haven't checked it lately, but there was talk about making PPIs OTC in the near future too. Would be nice
 
Interesting stuff...have tried reducing acidity of my stomach lots of time when I used to take meth. Always with bicarb or over the counter quickeze or whatever. Didn't realize it would have such a strong potentiating effect with opiates.

So is the only interaction from the fact that you have a less acidic stomach or could something else be adding to it as well? Will have to look up this med, not really familiar with prescription antacids.

*harm reduction hat on*

Don't consume heaps of antacids for long periods if you don't need them. When you stop your stomach will still be compensating and crank out the acid at levels where it could do damage. (this could be sketchy info as I'm doing it off memory alone)
 
I might have to track some of this stuff down. I'm in much the same scenario as you Psilo. I've had a few good recreational doses of codeine but I now have to take 6-700mg+ even to feel some slight sedation, practically no euphoria or opiate warmness you'd expect. Have tried potentiating with Promethazine but it only really adds more sedation.

Is this stuff expensive ?
 
Christ! said:
Interesting stuff...have tried reducing acidity of my stomach lots of time when I used to take meth. Always with bicarb or over the counter quickeze or whatever. Didn't realize it would have such a strong potentiating effect with opiates.
Click to expand...

I may be wrong but I thought meth was the opposite - it was absorbed in an acidic environment best, so taking antacids with meth would be counter productive.

And yeah the nexium is pretty pricey.
 
Here's some info, sorry wikipedia is the best I could do...the sources are all articles and books.

Adderall @ wikipedia -

Urinary and stomach pH levels can have a strong effect on DL-amphetamine excretion and absorption.[24] An acidic stomach and GI pH will decrease the absorption of Adderall,[10] and acidic urine levels will decrease the reabsorption of the drug through the renal system.[25]

Co-administration of acidic substances (e.g., citric acid) causes decreased renal reabsorption of DL-amphetamine; whereas, alkaline agents (e.g., antacids) may cause a marked increase in renal tubular reabsorption. The increased reabsorption can increase the retention of amphetamines, with potential to result in dangerously high serum levels.[25]
Click to expand...

I think methamphetamine is the same but could be wrong. I think the actual initial absorption rates are higher with alkaline ph also.

When I tried it I did get longer lasting effects, but it wasn't all that great...more of a buzzy, physical type feeling rather than the initial high. High pulse rate, insomnia much worse than I would have gotten normally.
 
^ Ah k yeah, looks like you're right, I'm not sure why I thought it was the other way around but for some reason I've had that in my head. I guess it doesn't really make a difference anyway unless you're eating the stuff.
 
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