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Any good literature on what DRI drugs have the lowest discrimination ratios?

Cocaine is particularly non-discriminating, so it's an odd point of comparison. I know that I have a table containing relevant data sitting on my other computer, so if I remember, I'll dig through.

ebola
 
ebola? said:
Cocaine is particularly non-discriminating, so it's an odd point of comparison. I know that I have a table containing relevant data sitting on my other computer, so if I remember, I'll dig through.

ebola
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'Discrimination ratio' here is reinforcing affect on a living subject's "discrimination" between different drugs of a similar class, not the "discrimination" of a single drug between receptors & receptor sub-types.

D.R. = Discrimination Ratio = [3H]DA ÷ [3H]CFT.

A low D.R. = addictive, whereas a high D.R. = low propensity for self-administration.
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Anybody?

Also, does anybody know any good chemistry/molecular biology sites that have calculators that may take input numbers between different values to create things like discrimination ratios out of NET & DAT relative affinities or anything like that?
 
Employing a D.R. was HM Deutsch's idea. It doesnt seem to have caught on among other authors and might not be that reliable as an indicator. The Cl2 analog definately warrants some further investigation. I can only guess what reasons are why it hasnt appeared on the RC market.
 
Smyth2 said:
The Cl2 analog definately warrants some further investigation. I can only guess what reasons are why it hasnt appeared on the RC market.
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I'd settle for a full name and/or an abstract at this point. That one has been haunting my thirst for understanding RCs for some while now.
 
Smyth2 said:
The Cl2 analog definately warrants some further investigation.
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Found it in the full text from the source: (±)-threo-3,4-dichloromethylphenidate, (abbr. "3,4CTMP"), thanks to this chart. Out of the hundreds and hundreds of novel DRIs I've glanced over, phenyltropanes or methylphenidate analogs, this appears to be only one evidenced as more addictive than cocaine itself. (someone prove me wrong on that)

Strange, the Wiki article says it has lesser reinforcing effects than TMP itself.
 
sekio said:
I think the lipophilicity limits the speed of onset in 3,4-diCl-TMP and therefore the abuse potential.
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Most phenyltropanes have lower lipophilicity than cocaine too, is there *any* DRI which has a higher lipophilicity than that standard litmus test of tried & true Methyl benzoylecgonine? It seems having a lower D.R. and a higher lipophilicity than cocaine itself is trying to find a needle in a haystack.
 
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