Just a warning, my posts are ususally not for people with poorly managed ADHD, not interested in other aspects of drugs aside from getting high, or have poor reading comprehension abilities.
methaqualone is not a barb dude
Yes thank you for enlightening me. To quote myself a few posts back
the US methaqualone, which isn't a barbituate, was called qualuudes and fueled the 70s sexual revolution. It has purported unique effects as an aphrosiac.
However, there pharmacology is sufficiently similar, and this was such a clasic material that it waranted mentioning- besides the question was brought up by the OP. Howver, this is the European
and African Drug discussion and Southern Africa is the only region to have a sedative scene of note, coincidentally involving mandrax, a peculiarity of that part of the world. Since all the good barbs (short acting) are hard to find in most continets as well as the non barb sedative hypnotics like, Paraldehyde, Chloro Hydrate, Placidyl (ethchlorvynol), Glutethimide (doriden)- that also has an anticholinergic effect in high doses, methprylon, ethinamate, meprobamate, and of course etOH (alcohol). There is also a steroid depressant binding site postulated on the GABA-A ligand gated channel. Barbs are postulated to actvate GABA-A and antagonize AMPA, etOH the NDMA, both of which glutamate is the putative ligand- but they sometimes co-occur on the same posynaptic terminal- implying same net effects- but i think the high has a different nuances- like different shades when your talking colors.
The other non- barb sedatives have differences- paraldehyde makes your breath smell- used to be the agent of choice for alcohol detox, Paraldehyde was great- it produced a nice swimmy high- the pills were gelatin caps filled with liquid- kinda like the omega 3 supplements that were red (500 mg). You would feel a slight warmth or burning sensation when they hit your stomach but the high was grrreeeatttt! They made you very incordinated, kinda like seconal but more pronounced, and best of all, they were only schedule IV in the US. Discontinued in 1999, I got them in the early to mid 90s from a Dr. in his 80s. Probably long retired. I felt that they were superior to seconal in some ways.
Chloral Hydrate worked well for me to get to sleep- probably the best one- slept like a baby and woke up refreshed. Now its raley Rxed. The peculiarity- some studies found that it dirupted normal sleep architecture alot less than other sedatives. Now you have GHB reported to work via another binding site or system (I've heard GABA-B mentioned.) One thing these drugs, structurally derived from barbituric acid or something else is that though alot of people like benzos- they blow them out of the water in terms degree of euphoria of high and abuse potential/ lethality. They don't have a celing effect or antagonsit like flumanenil. Hence there use of a drug of choice in euthanazia. You used to be able to get pento alongside ket in Tijuana at the many animal pharmacies- a fact I discovered here on BL. Then the NY Times did a story on "death tourism'" and the animal pharmacist curtailed their sale of the drug (mexico is a very catholic country and the idea of selling euthanasia drugs for humans disuaded many- fucked things up for people who would have been able to try this rare high./ Then the DEA came down on ket but thats another story.
All these drugs have quirks. Methaqualone causes an antitussive effect (cough supression) and enhances opiate analgesia rather than causing hyperalgesia in the presence of pain like barbs. This would imply a special mechanism of action with a possible opiate component as well. Also it causes convoltions in overdose not the oposite (barbs are often used to treat seizures). The drug might actual raise the seizure threshold and this is caused by a toxic metabolite like in the case of meperidine.
My mother in law was strung out on them for several years and she said they were wonderful- too good- and complemented coke well. Though these arent barbs, and when comparing preludin to amphetamine, preludin might not be classed as an amphetamine- but thats another stimulant from the dustbins of history that was considered more euphoric and prosexual than methamphetamine- maybe the most prosexual amphetamine like stimulant ever on the market- it never made a comeback but ludes have- a major op was found in NYC and the drug began to increase rather than decrease it popularity in Southern Africa- West Cape and the country of Nambia being epicenters.
So anyway, most people have the swinging 70s lude impression as a party drug with a reputation to make uptight girls open up and get down.
My wife took mex mandrax in the late 80s or early 90s in Arizona were they called it "mex-X" based on its high and ability to melt away your inhibitions ( plus I think there was a M and X on its logo.)
In the link which I provided it shows the south african ghetto scene. Just like talking about drugs like coke and heroin and only showing people snorting them (or smoking gear) but not presenting the smoking of crack or shooting of gear- by people that live in the ghetto- I felt compelled to show the method in Capetown in the only region of the world were it is used and abised in appreciable numbers- a peculiarity in the region like Captagon in Saudi and other rich Guls states.
So I wrote about info on the scene, how its smoked using bottle neck on a smoking mixture called majat- how the powder is pressed in pills though its usually smoked- and how smokers have it crackle like mesquite when burning. Finally the rush is so strong that most users "ert" after smoking whit Pyp or whatever the Afrikanner word for it is, andoften have to be lowered to the ground less they hurt themselves (like nitrous) or from the intensity of the rush (like crack or a good issue of grear.) So anyone out there interested in drug scenes in other countries should check the last link out: the beginning and the 26:15 into it.
Africa is too underepresented in this forum, unfortunately because there are cool people throughout the continent. My best friend's dad waas an Englsihman from Capetown. One of my other current best friend is a black dude from Zimbawae. SA, Nambia, and a few other countries in the southern part of the continent are full of drugs. In Zimbabwe, lots of people drink and a few subersive sould smoke cannabis- em-jay, but he'd heard of mandrax but said that it and other drugs despite the aforementioned are looked down on and almost non exostant- atleast in his circle.
I'm not intentionaly needling you mrfloowers, but I stated atleast once that methaqualone/ etaqualone, ect... arent barbituates. But in all fairness my posts are long and hard to follow. But for the 1% out there on BL that trully love all aspects of drug study, I packed the responses to the OP in detail- with links to the methaqualone thread that has just about everything you would need to know.
As for harm reduction- a currious sort wanting to try the fabled mandrax should know what it looks like, its health effects, how to avoid injury, and what to suspect. Also hou to smoke the drug without waste- it amazes me that crack pipes look more or less similar around the world, meth/tick pipes and light bulbs too, heroin smoking aparati- foil and a tooter, and the mandrax method using a white pipe (neck of beer bottle plus a smoking preparation called majat mixed with crushed madrax pills- made in factories primarily in Mozambique, Tanzania, on SA itself, with the precursors comming from India.
And like I said its important to see the drug in its idealized setting. Wonder if the animal pharms are selling OTC nembutal (pentobarbital) anymore. 200-300 mg would do me good- would get that energy you get when comming up on your first few drinks without the nausea and body load that someone pointed out. With barbs, after an hour or two, didn't get that poisoned, can already feel the hangover comming, feeling depressed, burnt out. Just the euphoric energy from alcohol and good sleep at the end of the party.
Dont forget the barb/speed supermixture. With valium to come down with
Always wondered why someone didn't remaked these
short acting Barbs. I think the precuror, barbaturic acid, is theoretically easily derived from plain old abundant urine.
There is a receipe for ludes involving making the hard reagent anathrillic acid from toluene. Maybe glacial acetic acid in the place of Aceytic Anhydradide- can't remember. Cant say were to find the receipe, but I'll tell you, the guy's a Cheapskate.
But most of my posts are written for people with long attention spans that have an interest in the particular field. Nobody is forced to read whats written except the mods (Sorry Samhain).
Wonder if barbs are availble down there again in the doggy pharmacies- these are dangerous times to make trips down there despite the fact that the place remains a huge open air- with several drug spots and superspots not counting the liberal pharmacies (some of which would sell illegal drugs out the back door all the while having crocked cops provide security for the market place).
Felt blasphemous to take via a different ROA but was best not to risk shooting em, didnt have enough to get a buzz via a different ROA, only had 2 or 3. They were like a tenner each iirc