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Yeast making LSD

Sounds like we're going to be seeing more LSD in the future. I can't complain.
 
sekio said:
Is it not easier to culture Claviceps?
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I don't know - is it? I suppose it depends on who's doing it and what their facilities are.

Doesn't Claviceps produce a mixture of ergot alkaloids - sounds like they're aiming for just lysergic acid.

Either way, I think this is pretty interesting of it's own right.
 
2 steps out of god knows how many, call us again in a decade when the rest of the steps are working.

there really isn't a lot of point to this, lysergic acid via paspalic acid from fermentation is cheap high yielding and fully sorted, globally there is no shortage of commercial ergot alkaloid production capacity.
 
Won't this make it easier for even newbie chemists to make the "challenge compound" that is LSD?
 
I don't think there is any lysergamide-n-ethyltransferase in nature... Lysergic acid is possible but I DOUBT it severly that it'll ever produce LSD.

I'd stick with c.paspali but very interesting nontheless!
 
vecktor said:
no it makes no difference, LSD is not difficult to make
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I don't mean to be rude but I feel like LSD is a difficult chemical to make, at least in many people I know's eyes. Doesn't it require expensive glassware and regulated precursors?

Correct me if I'm wrong though, I probably am
 
specialspack said:
I don't know - is it? I suppose it depends on who's doing it and what their facilities are.

Doesn't Claviceps produce a mixture of ergot alkaloids - sounds like they're aiming for just lysergic acid.

Either way, I think this is pretty interesting of it's own right.
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No, there are strains developed that just produce d-lysergic acid amide. And I am near certain that some have been engineered to produce enzymes that diethylate the amide.
 
^ it is not even as complicated as that, in the the late 1960's and early 1970's a series of papers showed that using C purpurea in submerged culture it was possible to make LSD directly through fermentation. in case anyone wants to look the main paper is listed in the Merck index under lysergide.
 
I know of these cultures to improve alkaloid yields but for actual LSD production through fermentation? Could you elaborate because i'm not able to access the merck index.

Lysergide =/ LSD

lysergamide-n-ethyltransferase in nature ???
 
rakketakke said:
I know of these cultures to improve alkaloid yields but for actual LSD production through fermentation? Could you elaborate because i'm not able to access the merck index.

Lysergide =/ LSD

lysergamide-n-ethyltransferase in nature ???
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lysergide = LSD, proper INN
funny some psychedelics have INNs (international non-proprietary names), MDA is tenamphetamine, DOB has one too though I don't know what it is, somebody sometime bothered to register the INN.
the paper referenced is Arcamone et al Proc. Royal Soc (london) 155B 26 (1961) I think the actual paper is next to the ref given it was a very long time ago I read it.

I doubt in this case the LSD is made by N-ethylation of the amide, in general -alkylating amides is more than a bit tricky, I would also have thought the hydroxyethylamine doesn't arise this way as in the peptide ergoloids ergotamine an similar the peptide portion is assembled then attached
 
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