Ethanol and Oxymorphone!?

[sprockets2000]

3. The method of claim 1, further comprising informing the patient or physician that the oxymorphone mean AUC after co-administration of 240 mL of 40% alcohol is not statistically significantly higher.

4. The method of claim 1, further comprising informing the patient or physician that the Cmax of oxymorphone increased on average by about 31%, and up to about 260% in individual subjects, following concomitant administration with 240 mL of 20% ethanol.

5. The method of claim 1, further comprising informing the patient or physician that the Cmax of oxymorphone increased on average by about 7%, and up to about 110% in individual subjects, following concomitant administration with 240 mL of 4% ethanol.

6. The method of claim 1, further comprising informing the patient or physician that the oxymorphone mean AUC after co-administration of 240 mL of 20% alcohol or 240 mL of 4% alcohol is essentially unaffected.

7. The method of claim 1, further comprising informing the patient or physician that the patient should not consume alcoholic beverages or medications containing alcohol when using the extended release oral dosage form of oxymorphone.

8. The method of claim 1, wherein the effect of the ethanol consumption on mean Cmax of oxymorphone is about 40% greater than the effect of food consumption on mean Cmax of oxymorphone.



From the above can I gather that ethanol may be a good way to get a great buzz off opana without having to snort?

 

[sekio]

Except for the fact that ethanol interacts rather strongly with oxymorphone. That figure is roughly equivalent to having 2x250ml cups of wine, and that's a significant amount.

Oral bioaviliability stays the same, as judging by the fact the AUC stays the same. so no, it's better to stay off the alcohol, unless you like chasing overdoses.

 

[Droppersneck]

I was just thinking about posting something about mixing opana and booze. I generally always mix the two b/c I feel like I get alot more out of the opana if I have 5 or six drinks in me. I have done this many time with and without alcohol so I dont think its just in my mind.

 

[negrogesic]

This is tricky......240ml at 20% would be something like four shots (~1 fluid ounce) of vodka/gin (80 proof). In a person with little tolerance to alcohol or GABAergics, 4 shots/ounces of vodka would elicit relatively profound CNS depression, decreased respiration, and hypnosis etc. If said person, lacking tolerance to alcohol, were to consume this amount of alcohol, while taking oxymorphone, it is possible that one could run into some potentially serious problems.

Furthermore, if said alcohol intolerant individual reacted similarly to the test subject with the 260% Cmax increase, the risk of fatal overdose could be very real. Plus, both drugs are pro-emetics, and even if respiration rates were only somewhat reduced, pulmonary aspiration caused by emesis while unconscious from the cocktail could easily result in death.

Nonetheless, it is interesting.......but please post the entire study, as I am curious as to where Tmax shifted along the curve. Also, it is the variances in Cmax that are more relevant in terms of pharmacological impact, although this is not to say AUC is irrelevant.

I cannot personally condone this combination as a clinician, but again, post the entire study, as the opiophile in me is a bit curious.....

 

[Droppersneck]

Lol, I am currently testing this study, but I have an good tolerance to both. I think alcohol potentiates opiates without any question. Throw a benzo in there and you are doin okay imo

 

[sekio]

Here's the link to the patent in question.
http://www.faqs.org/patents/app/20090124650

 

[sprockets2000]

This is tricky......240ml at 20% would be something like four shots (~1 fluid ounce) of vodka/gin (80 proof). In a person with little tolerance to alcohol or GABAergics, 4 shots/ounces of vodka would elicit relatively profound CNS depression, decreased respiration, and hypnosis etc. If said person, lacking tolerance to alcohol, were to consume this amount of alcohol, while taking oxymorphone, it is possible that one could run into some potentially serious problems.

Furthermore, if said alcohol intolerant individual reacted similarly to the test subject with the 260% Cmax increase, the risk of fatal overdose could be very real. Plus, both drugs are pro-emetics, and even if respiration rates were only somewhat reduced, pulmonary aspiration caused by emesis while unconscious from the cocktail could easily result in death.

Nonetheless, it is interesting.......but please post the entire study, as I am curious as to where Tmax shifted along the curve. Also, it is the variances in Cmax that are more relevant in terms of pharmacological impact, although this is not to say AUC is irrelevant.

I cannot personally condone this combination as a clinician, but again, post the entire study, as the opiophile in me is a bit curious.....

hmm I agree, I didnt realize how much alch it was actually proposing until you responded.