Non-cannabinoid appetite stimulants

[rolodex propaganda]

I suffer from a lack of appetite when I don't smoke. I feel as if I'm so full of gas that I can't eat. If I do I may vomit if I eat too quickly.

I've been off weed for 36 hours now as a tolerance break, without significant improvement. I need to eat, but I can't just live stoned. I have such a fast metabolism that my doctor tells me to eat 4000 calories a day, which is quite impossible without the munchies.

I've looked into other appetite stimulants, such as progestins, cortisosteroids and periacitin but they all seem to have bad side effects. I can really screw up my hormones with progestins or steroids and I read that periacitin reduces setononin production and leads to reduced HGH production. I'm doing this so I can gain weight, so none of these seem like great options.

I take doxylamine at night to help with the histamine release from my allergies and Suboxone, so I'm worried that if I included another antihistamine it could interfere with the effectiveness of this one.

As much as I love weed, I want to have the freedom to a healthy appetite with it. I plan on going with this tolerance break (40 hours so far) until the symptoms subside.

Perhaps it could not be rebound from the cannabinoids, but I could actually have something wrong with my stomach? Should I see a gastroenterologist or get some OTC drugs?

 

[kken]

pregabalin is a strong appetite stimulant

some weaker ones: mirtazapine, seroquel

 

[rolodex propaganda]

pregabalin is a strong appetite stimulant

some weaker ones: mirtazapine, seroquel

These are drugs used mainly in psychiatry. The side effects of these drugs would be worse than those of marijuana. Also, I read that tolerance builds quickly from 25-300mg with pregabalin. I'm looking for something I can take long-term that will stimulate my appetite without turning me into a zombie. Maybe that's too much to ask for.

 

[DJHENRU]

according to this it isn’t linear or whatever, the nausea fighter isn't the same chemical as the appetite increaser
I remember something about some b vitamins... unfortunately in class I don’t really have the time to investigate into them all further

I know times when I added 5htp with cannabis I got crazy munchies.

^^pregabalin is? I never really noticed that with it.

 

[rolodex propaganda]

Thanks for the pie chart DJHenru, it explains why JWH isn't as effective as cannabis as an appetite stimulant.

The chart says, however, that Delta9-THCV is an anoretic, through CB1. This would mean that it suppresses appetite rather than stimulating it. What am I missing here?

I'm worried about Pregabalin because even though it is effective as an appetite stimulant, I'm worried about messing with my GABA system. I know it's not as bad as benzos, but I prefer not to bother those receptors.

Can anybody who has experience with Pregabalin comment? The thread linked below indicates that tolerance builds quickly, as with Benzos.

http://www.drugs-forum.com/forum/showthread.php?t=129178

 

[sekio]

THCV is a CB1 antagonist, it has the opposite effect from THC and is like a natural version of rimonabant. It's not present in very high levels at all in psychoactive marijuana.
I would avoid messing with GABA-based drugs for long-term therapy.


The serotonin system is definitely implicated in hunger and digestion, try a 5-ht2C antagonist, maybe?

 

[negrogesic]

Antagonism of 5HT3, H1 antagonism, open chain synthetic opioids, and yes, gabaergic modulators increase appetite. For me, appetite stimulants are an obsessions of sorts, for which I have self-prescribed up to 120mg of mirtazapine a day. Methadone was a drug that I had used to combat narcotic addiction, wiith great success. Methadone is a marvelous appetite stimulant, however it is a powerful narcotic and its use for this purpose is not worth the trouble.

Cannabinoids are, agreed, a nuisance, and are too psychoactive. There is an OTC supplement called" black hole" which uses synthetic cannabinoids; it has some efffect but it is transient and insignificant.

A powerful appetite stimualnt is the veterinary anabolic-androgenic steroid boldenone. It is not indicated for human use in the US, and is used primary for increasing mass in livestock Do not fuck with your endrocrinology unless you fully understand the implkcations, consequences and fragile balance of the HPTA 'axis'. Nuke appears to have some more insight on endrocrinology than I; i studied the field by necessity but am by no means an endocrinologist.

I will say this: while gabaergics can be used as apppetite stimulants, their addiction potential outweighs the risk. Opioids can be used in a similar fashion, but is not advisabe (canines given post-op duragesics will eat without end). Mirtazapine is perhaps the safest call, and is perhaps, dare I say, neuroprotective............

 

[(zonk)]

i dont if this was mentioned but what about ghrelin analogs like ghrp-6...

 

[Qnick]

First off: Sweet name, my favorite ATDI song ^^

And secondly, if you're taking a smoke break from formerly having been constantly smoking, your body's appetite may have adapted to being under the influence of cannabinoids all the time.

It may just be a transient phase before you are able to eat more without cannabis, and your natural appetite may never equal the munchies but you will be able to eat what you need.


That being said, I realize this wasn't really a reply to your question, so sorry for that.
Good luck finding what works for you.

 

[negrogesic]

Yes that is a good point.....but from what little I know, it doesn't seem" that" promising...........there are certainly some peptides of interest but the data is sparse. There is not a huge societal damand for appetite stimulants, it is in large part why mirtazapine is clinically under-utilized........medicinal chemistry unfortunately follows the dollar, and there are many more dollars on the anorectic side of the equation...............






.

 

[interleukin]

i dont if this was mentioned but what about ghrelin analogs like ghrp-6...

GHRP-6 is the best short acting apetite stimulant. You have to make sure to eat helathy on it because the hunger can be so overwhelming that it will be hard to resist eating everything in sight for those 30mins. Unlike steroids you can take it almost whenever you want and have minimal side effects. Also, if used in a proper manner it can get you completely ripped (just like synthetic HGH). If you are concerned about nutrition when you have no apetite or are feeling sick, consider weight gainers + protein shakes. Can get ~ 1k good calories from downing 2 glasses of them.
To build up an apetite normally you have to eat many small meals a day to change the pattern of GH and cortisol spikes. Within a week you can easily go from no apetite to constantly hungry.
I would stay away from psychoactive substances to be healthier and gain good weight.
Also, there is no way your body requires 4k calories to maintain its current weight unless you tried really hard to get to where you are now (binge eating, steroids + excercise...).

 

[Fixed5217]

in the risk of getting 'stoned' for saying this, have you tried this good old-fasioned appetite stimulant: physical activity.
Holy cow i've got the munchies when I return home from the gym, a bike ride, etc.

 

[FPU4eva]

i got major addicted to pregablin, taking 1500mg a xay going into a catonic state for a week in the icu it also fucked up my GABA receptors so beware i take 225mg a day now sometimes i double dose

 

[Wizzle]

These are drugs used mainly in psychiatry. The side effects of these drugs would be worse than those of marijuana. Also, I read that tolerance builds quickly from 25-300mg with pregabalin. I'm looking for something I can take long-term that will stimulate my appetite without turning me into a zombie. Maybe that's too much to ask for.

I disagree. I use 15 mg mirtazapine a day and for me the appetite thing is the only downside. It helps me sleep wonderfully and increases libido ..

I am and was not depressed when I got it prescribed, and don't really notice any mood change although it might be there. Cannabis has significant side effects for me, most prominent is lack of motivation and ambition. I'm glad I haven't touched the stuff in more then a year.

The increased appetite is manageable, I haven't gained any weight while on it. I exercise a lot though.

 

[pofacedhoe]

in the risk of getting 'stoned' for saying this, have you tried this good old-fasioned appetite stimulant: physical activity.
Holy cow i've got the munchies when I return home from the gym, a bike ride, etc.

yeah- if spend all day sitting around, wether at work or at home it isn't going to generate much of an appetite, also lack of movement can lead to too much gas in your guts making you feel bloated.

also you are on suboxone- are you constipated? cos when i was constipated on opiates my appetite was rubbish

also try getting omega 3 fish oils or eat fish like trout and oily salmon, definately increased my appetite hugely. in fact it puts me off taking fish oils too often as the hunger can be unbearable

 

[rolodex propaganda]

pofacedho - I take .82mg (weighed on a mg scale) of Suboxone nightly at 5:00. However, I seem to have an easier time eating in the evening than the day when I'm not stoned.

interleukin - is GRH6 even commercially available? I can't seem to find it. What's the risk of hormones that mess with growth hormone compared to anabolic steroids? Injections aren't an option but I would consider taking something like HGH orally if possible.

on the note of mirtazipine - I've been reading more about this and it's seeming more and more interesting. I'm just afraid of antidepressants because I used to take Prozac and it made me suicidal. I began to feel significantly better almost immedietely after stopping the drug and have been very happy since. I'm worried about messing with my brain chemistry with mirtazipine for this reason. As a side effect, does appetite start to emerge as a strong effect at lower or higher doses?

Looking at the receptors Mirtazipine hits, I see it's an antagonist on several serotonin receptors significant to tripping. Without going too off topic, how would this affect psychedelic drugs and what I have gained from them?

 

[rolodex propaganda]

pofacedho - I take .82mg (weighed on a mg scale) of Suboxone nightly at 5:00. However, I seem to have an easier time eating in the evening than the day when I'm not stoned.

interleukin - is GRH6 even commercially available? I can't seem to find it. What's the risk of hormones that mess with growth hormone compared to anabolic steroids? Injections aren't an option but I would consider taking something like HGH orally if possible.

on the note of mirtazipine - I've been reading more about this and it's seeming more and more interesting. I'm just afraid of antidepressants because I used to take Prozac and it made me suicidal. I began to feel significantly better almost immedietely after stopping the drug and have been very happy since. I'm worried about messing with my brain chemistry with mirtazipine for this reason. As a side effect, does appetite start to emerge as a strong effect at lower or higher doses?

Looking at the receptors Mirtazipine hits, I see it's an antagonist on several serotonin receptors significant to tripping. Without going too off topic, how would this effect psychedelic drugs and what I have gained from them?

 

[paranoid android]

pofacedho - I take .82mg (weighed on a mg scale) of Suboxone nightly at 5:00. However, I seem to have an easier time eating in the evening than the day when I'm not stoned.

interleukin - is GRH6 even commercially available? I can't seem to find it. What's the risk of hormones that mess with growth hormone compared to anabolic steroids? Injections aren't an option but I would consider taking something like HGH orally if possible.

on the note of mirtazipine - I've been reading more about this and it's seeming more and more interesting. I'm just afraid of antidepressants because I used to take Prozac and it made me suicidal. I began to feel significantly better almost immedietely after stopping the drug and have been very happy since. I'm worried about messing with my brain chemistry with mirtazipine for this reason. As a side effect, does appetite start to emerge as a strong effect at lower or higher doses?

Looking at the receptors Mirtazipine hits, I see it's an antagonist on several serotonin receptors significant to tripping. Without going too off topic, how would this affect psychedelic drugs and what I have gained from them?

Mirtazapine increases my appetite a lot at low doses. I was put on it for bipolar depression years ago and i started on 15mg's which is the usual starting dose i believe. It is a knock out drug because of it's very strong anti-histamine properties (it's one of the best anti-histamines out there) but my hunger would override the drowsiness caused by the mirtazapine. I would end up clearing out half the goddamn fridge because i literally could not get full no matter how much i ate. Makes cannabis look like cocaine in terms of giving you a appetite.

Also low dose tricyclics especially amitriptyline might help. I was on that for maybe 2 years at 100-150mg's a day and i could never loose weight on the stuff. No matter how much i worked out with weights and cardio, no matter how much i watched what i ate and no matter how active i stayed i just could not loose the weight. I was not fat really just chubby considering I'm normally about 175lbs but on the amitriptyline i went up to 200lbs and got that sorta puffy look. But i had also quit smoking at that time too so that no doubt played some part.

A lot of atypical anti-psychotics can put the weight on you but I'm guessing your not wanting to go that route

 

[Fixed5217]

so working out is out of the question? You can only experience positive benefits doing what you were meant to do; these chemicals, and I will against my better judgment add JWH's to the list as a sure fire way to conjure munchies,--these chemicals seem to have a plethora of negative side effects your better off avoiding.

 

[BlueCrest]

on the note of mirtazipine - I've been reading more about this and it's seeming more and more interesting. I'm just afraid of antidepressants because I used to take Prozac and it made me suicidal. I began to feel significantly better almost immedietely after stopping the drug and have been very happy since. I'm worried about messing with my brain chemistry with mirtazipine for this reason. As a side effect, does appetite start to emerge as a strong effect at lower or higher doses?

Looking at the receptors Mirtazipine hits, I see it's an antagonist on several serotonin receptors significant to tripping. Without going too off topic, how would this effect psychedelic drugs and what I have gained from them?

I was prescribed citalopram (SSRI) for mild depression one year ago and it was garbage. It didn't make me suicidal but emotionally numb. I quit after a few weeks and felt a lot better without.

Mirtazapine is different. I wasn't prescribed it for depression but as a sleep aid a few weeks ago. 15mg at bedtime. Nevertheless it really improved my mood. Not in an emotionally numbing way as with SSRIs but more like the natural high I get after working out or running. It also takes the edge off my ADHD medication which can be an emotional roller coaster at times due to methylphenidate's short half life.

The appetite stimulation was really too much during the first days. I started cooking in the middle of the night even though I could barely stay awake. After a week, the appetite stimulation was a little reduced but I'll still have another meal after I take the mirtazapine and before I go to bed. The sedation was mostly gone after one or two weeks but my sleep is still improved.

Mirtazapine is said to diminish the effects of serotonergic psychedelics but apparently it doesn't block them completely. Some people report tripping fine while on mirtazapine.