Ok, lack of proper word, substitute retarded for ill-informed. Anyone wight rh capability of reading, and has 15 minutes can clearly site maps, and scan through hundreds of creditable sources pointing to MDMA neurotoxicity. All these studies may be inconclusive because they cant specially relate them to the human brain, but in general it's very similar. A muscle cell acts like a muscle cell, a liver generally acts like a liver, a stomach generally acts like a stomach, and a serotonin axon, terminal and receptor site generally acts like a serotonin receptor, axon and terminal, regardless of the species.
Sure it a bit more complex, but anyone can obviously see that it correlates. I like to ask you, where did they test ssris before the first ever therapeutic prescription was approved by the FDA for use in humans? In rats/animals. Why? Because it affects the serotonin system generally in the same way as it does in humans, as it does in rats. Look how far we've come from then, there's no way they randomly picked a depressed guy that didn't care what he took it of a hat for testing, it's unethical, immoral and illegal.
Post creditable sources? Google it, map it, pubmed it, I'm not wasting my time. If your going to refuse it, then go ahead, be arrogant. Look at the details and in-depth coverage and methods used in numerous studies, clearly there not bullshit. Saying a rats serotonin system can't "generally" relate to ours, is like saying there hippocampus is unable to grow with maze learning, that's like saying their muscles aren't like ours and are unable to grow with exercise, or that fat cells can't be burned. There's a reason rats are used in almost every pharmeceutical drug testing operation.
Now there's clear a difference aswell, size (why they use % based on humans), metabolism (effecting recovery rate) and many other little things, but nothing extreme enough to cancel out neurotoxicty. Maybe if their stomach had a whole different mechanism as ours then MAYBE.
So what dude? You used and never felt consequences, congradulations. I rolled 300+ pills in 4 years and never felt any negative effects EVER, happiest guy around, was doing better in uni than most straight edged nerds. Ive popped up to 11 pills in a night, blacking out and then going back to school the following monday with no noticeable change. It wasn't until I reached my final binge that wreaked havoc upon my life, your brain can only take so much, it's very resilient, but not impervious. Who ever doesn't believe this is plain stupid "IMO".
Referring to "IMO" earlier, I was talking about the correlation between ppl being fucked from over use, even moderate. You don't see that shyt in cannabis discussion do you? No. So please, either stop being so negligent, or go and roll everyday for a few months if it's "inconclusive" then come back and tell me how you feel.
This argument is stupid and won't go anywhere.
Now what's being done to your brain "theoretically" is, toxic metabolites of MDMA unleashing free radicals upon your brain which pluck electrons from your serotonin axons to become a stable compound, excitiotoxicity from a crazy amount of activity of serotonin, once the initial rush of serotonin happens due to MDMA-dopamine begins to be picked up in your serotonin receptor sites causing then to "self-destruct" basically. And of course, downregulation of your 5HT terminals from such an abundance of serotonin, it's your body's natural defense. Also, hypergtemia greatly increases neurotoxicity bc your body can regulate it's temp on MDMA.
Now if you dint believe me, MAP it, you'll find something regarding each one of those methods of action.
Of course adulterants in pills contribute, think about it, one theory is that dopamine is reuptaked into the serotonin receptors causing harm, so clearly a pill cut with meth or smt (a dopamine releasing agent) would clearly add to the amount of dopamine being wrongfully took up by these receptors. As well as some adulterants easing body temp, which doesnt help, and whatever other shit is in the pills we don't know.
thanks
