RCs Methoxetamine and MDPV

[ektamine]

Be very careful. I know that plugging is different from IV'ing, and MDPV is vastly different from MDAI... but keep in mind the only reported death (that I know of so far) from methoxetamine came from IV'ing methoxet with MDAI. Mind you, that persons doses were rather high (100mg methoxetamine & 400mg MDAI), but still... death is no joke.

 

[Thanatos]

Tried the pv and mxe combo a couple of times recently and I've gotta say it's not too bad. I took moderate ~ 35 and 60 mgs of the mxe, respectively with 20 mgs of the mdpv vaped each time.
It didn't feel toxic what so ever, it actually felt like there was pretty good synergy. Methoxetamine is so sedating at the peak, so the pv really helps give a little more energy and enactogen push to the experience. They were quite nice trips to be honest. Very easy on the mind, and I felt rather lucid throughout the experiences. Not a trace of panic, mania, or anxiety.

 

[SmokeaJoint]

I've found that mixing RCs is a bad idea. That may just be for me though. But I vaped some mixed RC powers and it was one of the worst comedowns I've had in a while. Since I stopped smoking meth anyways.

 

[Thanatos]

^ doesn't have much to do with the thread... But anyways, mixing rc's can't necessarilly be a bad idea. You just have to titrate your doses and have some forethought into what you are going to ingest, taking contraindications and the drug profiles into account. I find that mixing certain chems can make the sum of the experience, greater than the individual parts. There is a lot to be said about synergy and taking lower doses of your prefered chems.
Going to take this combo at a rave next weekend, might substitute the peeved for some MDMA though.

 

[lynx2051]

I miss MDPV BADLY, I use to order it from the US but it's now banned there like the UK.

 

[Dedbeet]

Yeah, I have heard that MDPV has a tendency to cause paranoia and/or even up to psychotic episodes in some users.

Fwiw, that's highly unlikely with a reasonable size, one-off dose (e.g. 5mg). It seems here that if any dissociative has the potential to be OK with MDPV, it would be methoxetamine, based on reports from people that have used it. But still... why? Doesn't seem to make sense to mix a dissociative with a straight-up stimulant.

 

[sekio]

Methoxetamine and other arylcyclohexylamines are (way more selective relative to NET) dopamine reuptake inhibitors in their own right. No need to add more to it - especially in the norepinephrine reuptake depeartment, which is well known for inducing anxiety and paranoia.

 

[deckmunki]

Best answer: just don't do it. MDPV on its own is bad enough when things go wrong. MDPV and MXE combined shouts "acute hypertensive massive fail" to me (yes, that's a medical term... Ok, it's not really).

Longer answer: MDPV is a norepinephrine-dopamine reuptake inhibitor; MXE is thought to be a strong dopamine reuptake inhibitor. Both have a sufficiently long half life and small dose-effect levels (active doses are something like 5mg and 10mg respectively) that you could put yourself well onto your arse if you mix them thoughtlessly.

If you must, titrate upwards from 1-5mg doses, and have a good (24hr min) break between steps.

Best of British =o)

 

[Vaya]

In "Interview with a Ketamine Chemist: Or to be More Precise, An Arylcyclohexylamine Chemist," the inventor of MXE (a fellow bluelighter, so I've been told) does indeed purport MXE and related novel dissociatives as N-methyl-d-aspartate agonists, dopamine reputake inhibitors and mu-opioid receptor agonists, the latter two being more pronounced with respect to MXE's pharmacological mechanism of action, making MXE all the more novel in the RC market from both a buyer and a researcher's point of view.

This is all I'm gonna say to the OP regarding the MDPV + MXE combination (and somebody wisely mentioned the death in Sweden from 100mg MXE + 400mg MDAI IV injection - irresponsibility abounds!): I have attempted this combo over the past week (and thought it to be such an obscure/idiotic combination that this topic caught me completely off-guard!) and I want to say that IME amounts of 99%+ pure MDPV exceeding 3mg in combination with doses of MXE (sublingual, intranasal and intrarectal) in any dose produced intense paranoia, increased perspiration, increased heartrate, increased BP - in other words, an experience symptomatic of a panic attack. Reminded me of my first bad trip on LSD or Psilocybin ~10 years ago, and I am generally not one to experience 'bad trips' at this point in my psychonautic adventures.

Also, a general word to the wise (as has also already been mentioned): The combination of *any* two or more RCs can be absolutely dangerous. To a large, large extent we as a community of even those well-versed in neuropharmacology know very little, if anything about the safety profile of these compounds in humans. In fact, most of what we do know is based off of previously existing knowledge of compounds already in existence, like MXE's chemical relation to Tiletamine, Ketamine and (3-MeO)-PCP/PCE and MDPV's distant relation to methylphenidate. But these chemical relationships are hardly enough to be properly predictive in terms of the newer compounds' properties in human subjects. Regardless of whether or not our community's anecdotal reports confirm or deny that MDPV + MXE may or may not be pleasant and worthwhile experiences, what we do already know for certain is that the science does not exist to in any way to support the recommendation of combining two such chemicals in human beings. My anecdotal experiences suggest and support the notion that this particular combination may be potentially damaging, at least psychologically speaking, and my advice would be to refrain from experimenting further with them in concert.

~ Vaya

 

[Thanatos]

Ha, i had plenty of good experiences with this combo. Methoxetamine is so sedating that vaping a little free base pv after a hit of kines feels amazing. But I quite like mxe & pv, respectively.

 

[fistful_of_needles]

Listen guys , I´ve done this and it went something like the following: it´s general consensus that once one opts tp smoke mdpv as if it was crack the former somehow can turn just every single bit as fiendish and insidious as the latter ...so, I opted to smoke it like I´d do crack...all of you who´ve "researched" mdpv knows how dreadful/unforgiving the comedown may be so I was somewhere in that post-binge labyrinth wondering what to do with myself and I just remembered I had some MXE about ...WORST POSSIBLE IDEA...imagine the paranoia,anxiety etc etc MDPV produces completely amplified 100xs by the MXE or vice-versa...enter 4 digit heart rate paranoia,enter not having the faintest recollection of what I did from then on , MXE was making me trip waaay harder than any psychedelic I´d ever tried...well,VERY BAD IDEA in general ...oh , doses , yeah , MDPV was something ridiculously high like 200-300mg (smoked) and as for the MXE just eyeballed two small lines which defintely turned into anj altogether different beast once sy6nergysing with mdpv....might be different on small doses though , any ideas?

 

[ektamine]

Doesn't seem to make sense to mix a dissociative with a straight-up stimulant.

This. I've mixed everything with everything, which includes plenty of dissociative (usually ketamine, very similar to methoxetamine) + stimulant combination. The way I usually do it I dose predominately on the dissociative side and lighter on the stimulant side. With this I find the stimulant just keeps the dissociative effects from completely immersing me like they usually would, but the stimulant is hardly enjoyable beyond that. It seems like the effects have a 'push/pull' relationship to each other. Meaning the synergism between the two is not much. Of course, all is subjective, ymmv.

 

[thikal]

Be very careful. I know that plugging is different from IV'ing, and MDPV is vastly different from MDAI... but keep in mind the only reported death (that I know of so far) from methoxetamine came from IV'ing methoxet with MDAI. Mind you, that persons doses were rather high (100mg methoxetamine & 400mg MDAI), but still... death is no joke.

Erf... What a sad message! RIP ektamine, didn't know you at all but enjoyed all your posts

 

[foolsgold]

i always mix my mxe with 2-dpmp which is a strong stim and have the maddess times on it with out any bad affect

it all was seems as if reality has just been nuked and i become the central point of time gravity and everything as the world wooshes and swerls around me but yet i know its not really doning that but just cnt snap out of it . then we hit the stages god christ lucifur and the creators of what was before the big bang and likes . just to click and swagger round with this total power trip but mellow buzz going on for hours later . iv seen astec style buildings just drip off my finger tips before building into full worlds in the blink of an eye made boxes that i just cast away with the knolage that in them were whole univerese . shame i all most over did it last week and a very close run in with death

 

[TikTokTim]

This is a horrid combo responsible for the worst night (2 years) of my life. If you've ever been a fan of dissociative you've probably experienced the effects of time dilation with it. Ie, when a couple of months in your head end up being only a few minutes in actual time passing. Now imagine being in the grip of a horrid pv paranoia psychosis and then suddenly getting trapped in the hell of your time dilated mind for what seams like years. It is so bad. And it kicked over with just a small dose of MXE in the mix. Never again for me. But you go right ahead throw in a healthy dose of jwh-203 while you're at it. Just for good measure <p><p>and even after all that I still love MDPV. And MXE too! I just be sure to dance alone now

 

[sighhill]

I'm a ddaily MDPV user and last week my wife and I were binging harder than normal. On the 2nd morning of our bindge we tried MXE for the first time. I had gotten it in a few days before and was kind of scared of it. We started from the bottom and through a handfull of redoses worked our way up to about 30mg each our last hit. After that the next few days became a blur. A lot of bad shit has happened since that day I mixed MDPV with MXE. I think I was switching back and forth for about 3 days in a row before the cops ran me out of my own home. I wouldn't suggest anyone to mix this two.

 

[sweatloaf13]

being a former IV dope/cock abuser I've had my share of speedballs. If you've had one ou know how good it feels.....BUT when you find yr "sweet spot" with an IV whack of MxE/MDPV you've created fucking magick in a syringe. not to be used as a mommas's little helper but a nice treat when you think you're worthy. I find more MDPV with an MxE "sprinkle' works best for this guy here.
now back to harm REDUCTION.....(yawn) lol
just kidding folks

 

[Marauder]

I'm about to rail 30mg MXE and 5mg MDPV. I'm coming off 25mg MXE from about 5 hours ago and I take Effexor XR 150mg BID (high dose!)

There shouldn't be a problem in low doses of MDPV but as stated above, the MDPV crash comes on fast and hard, and you don't want to be in a paranoid state when you're peaking on MXE. It can be difficult to handle drug induced paranoia when in a dissociated state.

Will the combo be physically dangerous? Your heart will hate you (from MDPV alone) and your amygdala will be amped (chance of anxiety is higher) so proceed with care. Don't drive, don't walk around with weapons/drugs on you, etc.

Actually as I write this I feel like I have alice in wonderland syndrome (feels like I have no body while typing, head feels huge and other ridiculousness) and so I will only rail half the dose stated above.

Going with 15mg MXE and 2.5mg MDPV. The consequences even if not too probable are not worth the "research." Spending Saturday night in jail or the hospital is a buzz kill for you and your family and friends. Instead, do what I'm doing and start low working your way up SLOWLY. MXE hits in waves and it wasn't until I saw this thread and sat down that I realized how messed up I am.

Why am I re-dosing anyway? I suppose the sedating nature of MXE sometimes can be a drag when the day seems slow/boring. MDPV does give life a certain thrill.. it's the devil in HCl format. Matter of fact, I'm taking my own advice and cutting the line into 3 parts, waiting 1-2 hours between redosing IF I decide to (probably won't redose MDPV.)

Be safe everyone!

 

[crOOk]

3-5mg Methoxetamine, 3-5mg MDPV and 20-30mg MDMA (administered simultaneously, rectally) has proven to be an excellent stimulating, empathetic combination for those social occasions where you don't want anyone to know you're intoxicated. It makes me stimulated and focused in a very calm manner and also improves the pleasures of social interaction. I've also added 1mg 2C-E to this combo twice and had the time of my life, it added a lot of empathy, mental "clarity" and appreciation for life.

Just so you have an idea of my sensitivity to said drugs, my dosages for each on their own would be...
-50-100mg MXE rectally (huge dose, don't take this as advice!!!) for a dissociative journey that ends with me waking up and wondering wtf I've done last night.
-5-10mg MDPV in the a.m. for focus and energy
-90mg (T+0) + 50mg (T+30min) MDMA rectally for the time of my life (I do this once every year or every other year, sometimes more than once within a year)


I would clearly advice against combining MXE at dissociating dosage levels with MDPV. I cannot tell you an specifics, since the pharmacology of either substance isn't entirely clear to me, but the combination sounds like it is asking for a slap in the face. I don't particularly enjoy MXE, eventhough I'm a huge Ketamine and PCP fan (especially the former, HUGE fan, but not a habitual user of either!), but I do like MDPV a lot and it has immense value to me. I'm saying this so you know I'm not just talking down to you and your ideas about combining the two.
I used to combine Ketamine with Amphetamine on rare occasions before I got into using stimulants for academic purposes. It proved to be a very curious combination that left me stimulated for more than 24h. Since Ketamine seems to have pretty impressive neuromodulatory effects I cannot exactly tell you how the ketamine facilitated the stimulating effects, but it did for me in a very reliable manner.

Now if you want to gain insights into psychosis, this combination will probably be the answer. MDPV reliably causes mania if I overdose it (good times ) and dissociatives in general seem to be quite efficient at promoting a psychosis of schizophrenic nature from what I hear. Just bear in mind you might not recover from the experience, if you've ever experienced lingering thought disorder after use of psychotropic drugs or have a schizotypal personality, stay far away from dissociatives.

 

[mydrugbuddy]

Listen guys , I´ve done this and it went something like the following: it´s general consensus that once one opts tp smoke mdpv as if it was crack the former somehow can turn just every single bit as fiendish and insidious as the latter ...so, I opted to smoke it like I´d do crack...all of you who´ve "researched" mdpv knows how dreadful/unforgiving the comedown may be so I was somewhere in that post-binge labyrinth wondering what to do with myself and I just remembered I had some MXE about ...WORST POSSIBLE IDEA...imagine the paranoia,anxiety etc etc MDPV produces completely amplified 100xs by the MXE or vice-versa...enter 4 digit heart rate paranoia,enter not having the faintest recollection of what I did from then on , MXE was making me trip waaay harder than any psychedelic I´d ever tried...well,VERY BAD IDEA in general ...oh , doses , yeah , MDPV was something ridiculously high like 200-300mg (smoked) and as for the MXE just eyeballed two small lines which defintely turned into anj altogether different beast once sy6nergysing with mdpv....might be different on small doses though , any ideas?

I also experienced that feeling of what to do or take during an MDPV comedown, and MXE suggested itself to me. It seemed like a good idea at the time, hoping to feel that antidepressant cotton wool wrapped disociative state. I guess id probably smoked atleast 100 mg of MDPV over the course of the sesion and then took about 30-40mg of MXE.

Things started off OK, lying in bed with headphones on & getting well into some Bon Iver tunes. I think its when i tried listening to Can that i started to loose it. I found that once my mind had ceased attending to things in the external world and commenced some inward journey, then all i could do was melt into the bed. My thoughts slowed down to treacle and all colours became greys and browns. That was it really - i was totally stupified, couldnt think beyond thoughts like "need water!".

Throughout the whole thing though i felt no sense of fear or anxiety, as i might have experinced underlying a shroom trip. MXE seems safe in that regard. I later added an etizolam and haze canniboids to the experience and things then got very weird indeed. I felt like i was possesed by something other than myslef, that was trying to teach me what felt like important & valuable life lessons...but were probably/possibly just crazy gibbersih..