Illustrated Codeine-Morphine Metabolism

[killakillakam]

I am not sure if this has been posted before but here is a very well-illustrated representation of the pathways.

Perhaps this could limit the "potentiate codeine" discussions a bit?

Source: PharmGKB and Stanford University.
Thorn Caroline F, Klein Teri E, Altman Russ B. "Codeine and morphine pathway" Pharmacogenet Genomics (2009)
PMID:19512957​

I believe this falls under "fair use" so no copyright infringement accusations please.
If anyone feels inclined to send off an e-mail to PharmGKB as a courtesy please do so.

Here is the original LINK for those interested in further reading.


Cheers

 

[killakillakam]

Guess no one is interested in this...

 

[titstypedthis]

its useful but you said it yourself its gonna limit discussion... basically by providing a clear explanation for the reasons potentiation of codiene can and can't make it stronger and longer.

...

 

[Jamshyd]

I am personally well-aware of this particular image, and many of those who post in this forum are even more knowledgeable than I on this issue. On top of this, Bilz0r has done some extensive posting on this with references way back when this forum was started.

So in short, most of us are not really wondering about the stuff presented here. The problem is when you have newcomers who didn't research and who think the question is "too advanced" for BDD or OD when in fact it is precisely what those two (particularly OD) are concerned with.

That said, thank you very much for referencing it properly.

And with all that said, I'd actually like to leave this thread here to see if anyone has any objections or alternatives to it, of course assuming they have a hypothesis or research to back it up.

 

[Jamshyd]

basically by providing a clear explanation for the reasons potentiation of codiene can and can't make it stronger and longer

This makes absolutely no sense (in English).

 

[sekio]

basically by providing a clear explanation for the various reasons codeine can be potentiated or depotentiated by enzyme induction or inhibition

That's how I parsed that sentence.

 

[titstypedthis]

This makes absolutely no sense (in English).

you have a fundamental lack of understanding for the gibberish language that i fear will limit you severely in this life.

 

[killakillakam]

its useful but you said it yourself its gonna limit discussion... basically by providing a clear explanation for the reasons potentiation of codiene can and can't make it stronger and longer.

...

I was hoping I could get more discussion of the UGT class of enzymes rather than the oft cited 3A4/2d6.

Some suggestions of strong UGT2B7 inhibitors could provide useful harm reduction for people experimenting with unfamiliar substances.

For example, Valproic Acid inhibits UGT2B7 but has horrible side effects. On the other hand, Naproxen is a UGT2B7 inhibitor readily available... why isn't it being used more frequently?

 

[sekio]

Why would you want to inhibit glucuronidation? From what I've seen the glucuronides are still active as opiates.

 

[killakillakam]

Hmm... yes that is an important question. M3G is weak but M6G is supposedly stronger than morphine itself.