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Opioids Talwin NX (Pentazocine and naloxone) - damage to body?

A

Aeon's Requiem

Greenlighter
Joined
Apr 7, 2011
Messages
19
Greetings, fellow Bluelighters. I've been lurking the site for a little while now and think there's some very interesting people here. Hopefully, you guys can help me..

About five months ago I was prescribed 50mg Talwin NX for chronic knee pain. The naloxone is supposedly to prevent one from injecting powdered pills... anyway, they control my pain fairly well with the beneficial (?) side effect of making me feel pretty good. So good, in fact, that I eventually began taking somewhat more than prescribed.

The kicker here is that when I ran out, I felt like shit on toast. Too tired to move, runny nose, nausea, etc... so I assume I've built up a nice physical craving for my pills.

How much can I take of this stuff without risking damage to my system? Yes, I know that I'm probably well on my way to becoming dependent on these, but I'd like to make sure I hurt myself as little as possible. I'm a very thin woman, 100b., who also eats pseudoephedrine by the box (90mg every 3 hours or so).
 
I haven't really heard of pentazocine (opioid mixed agonist antagonist) before but wikipedia says it's "respiratory depression is subject to a ceiling effect" which means there is less danger of death due to acute overdose unless mixed with other depressants or completely opiate naive. That being said I'm really not sure what you are asking with...
How much can I take of this stuff without risking damage to my system?
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The toxicity of most opioids is quite low but you risk the usual dependence plus short and long term withdrawal issues. Perhaps if you refine your question we can help you better?
 
Firstly thanks for editing my thread title for clarity. :)

Refine my question... Hmm. I suppose I am wondering how much is safe to take without risking damage or death, because I rather like the high I get in addition to the analgesia. It's not the same as hydrocodone which usually makes me nauseous and ass dragging, where pentazocine speeds me up a bit. Then again, that could be the combination with pseudoephedrine.

I guess I'm just a little worried about setting myself up for a serious addiction. I'm aware that if I continue taking this stuff that I probably will, but I don't WANT to quit. Does this make sense? I also don't want to hurt myself, or as little as possible.
 
Well ideally then you wouldn't take any. If that isn't an option though because you do want to take some, then the less you take the better. As I said you probably aren't going to OD on it, but there is no way to determine the highest possible non-deadly dose without finding the deadly one. Furthermore there is no "safe" amount to take chronically where you can guarantee you won't be building up a physical or mental addiction.

The safest amount is the least amount.
 
Thank you, amapola. What you say makes sense.

Now from what I've read, naloxone is inert when taken orally. It's put into Talwin NX specifically to discourage a person from dissolving it for injection. Therefore I won't have to worry about being tossed into withdrawal as long as I only take it orally, right?

Which leads to my next question : can one ingest Talwin NX in any other way than orally? I'm given to understand that the bioavailability of pentazocine is fairly low when taken orally, and that another route could assist me in taking less. However the addition of the naloxone makes this problematic, it seems.
 
Buprenorphine outcompetes the naloxone in Suboxone preparations so it is fine to inject. I'm unsure what the affinity of pentazocine is though and whether the same would apply.
 
Talwin! Holy shit, I recall taking 2 of the.. Erm, I think 10mg ones (They were white) when 20mg of Hydrocodone made me feel ohhhh so euphoric. Needless to say I was yacking up a storm n didn't leave my bed for some hours. I did, however, catch a very pleasant buzz, and nod. Wasn't this stuff massively abused back-in-the-day?
 
Apparently at some point they were, which is why they put the naloxone in it in the USA now
:(

I'm prescribed the light greenish ones, which are 50mg with a small bit of naloxone. The tablets taste like sour death, and only make me nauseous if I run out and have to take something else (generally hydrocodone ) until I get a refill.
 
I guess they were 50mg, I can't find anything about 10mg pills, lol. How are they? Any euphoria to them? I wish I could get my hands on more of them, it was a one time thing I got instead of what was supposed to be 'Oxycodone'.. Pretty potent as I recall.
 
About twenty or thirty minutes after I take a couple (usually two, three on a bad day) I begin to feel a "quiet" feeling; sort of like all the pain both physical and mental melts away, leaving a calm glow that lasts for about an hour. I believe it has anxiolytic properties, because if I'm feeling stressed my Talwin takes care of it. After the hour or so of being in the calm zone, I feel a rush of energy, almost like a very small dose of speed. The tranquility is still there, though, and if I sit still I find myself staring at nothing and sometimes falling into an incredibly restful sleep.

This is only my experience ; also, my doctor recently upped my dosage so I'm not precisely abusing my pain meds I suppose... OK I'm fooling myself o probably am ;(
 
Glutithemine potentates the conversion of codeine into morphine from 10% to% 30, what does that have to do with the drug being discussed. Is that a metabolite? It says that nalaxone was added because of that. Also the oral ba is only 20% so I could see why other routes of administration would be favored.
 
But is it possible to use another RoA with these particular pills? I mean they already taste like shit :D

IV is not an option for me, I'm needle-phobic. Not knocking it, but it's not for me. I am more interested in possibly plugging it, because that may bypass some of the unpleasant stomach effects.
 
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It keeps me awake and still somewhere between the veil of legal and illegal. I'm broke so I can't buy the good stuff, plus my spouse would have kittens if he even suspected I was abusing anything... hiding it is probably not good but I am not ready for that particular argument right now.
 
Aeon's Requiem said:
It keeps me awake and still somewhere between the veil of legal and illegal. I'm broke so I can't buy the good stuff, plus my spouse would have kittens if he even suspected I was abusing anything... hiding it is probably not good but I am not ready for that particular argument right now.
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OK, i get that, makes sense.
These days i'm personally pretty much against "stimulants" but i was just wondering about the pseudoephedrine since real ephedrine is very easily available and also dmaa... + Your doses make my head spin since i'm a male and three times the size of you and 60 mg of it ONCE per day gets my heart pounding...

All the best.
 
I've had the sudafed habit for four years or so; I'm likely so tolerant to it that if I took it as directed I'd have rebound stuffiness etc. I know it's a ghetto form of speed and probably a big reason why I'm so thin, but at this point if I don't take it my ass drags like nothing else.
 
Everybody has their drug of choice :)

Took a fourth pill last night about two hours after taking three cause the weather has my joints screaming ... couldn't get to sleep AT ALL. It wasn't pseudoephedrine either, didn't eat any. I hate paradoxical reactions...
 
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