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Specific Antagonist for Ethanol

C

c0rt3x

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As I have developed a serve alcohol 'intollerance' after withdrawal following only one weak of daily consume at night time - I'm now finally looking for a way of reversing my now ultra sensible GABA receptors.

Although the common opinion is still that healing of long term alcohol dependence side effects is not curable at all - I disagree:

If Neuroleptika can be utilized to reduce tollerances of dopamine releasing stimulants by blocking reversing the unwanted desensibilation of the dopamine receptors than the very same trick is highly likely to work for GABA receptors just as well.


So my first idea was to try this with a GABA down regulating benzodiazepine specific antagonist.

Unfortunately the mechanism of action is far too different as to target the very same GABA and interrestingly NDMA sub receptors that ethanol has affinity to.


So how had the Ethanol molecule to be manipulated in order to be a specific antidote for alcohol poisening?

I'm not sure in this point but my intuition tells me that the -OH group had to been replaced by a -NH2 amine group (see Ethylene Glycol/Fomepizole) in order to make reverse its mode of action from an GABA- Agonist to an Antagonist.


Another matter of interrest might be the NDMA-Antagonistic side of Ethanol - but I guess that this might be relatively negletible to it's GABA related agonistic actions.

However DXM looks like it was well worth a try - emm trip... =D



Thx in advance for your thoughts and comments... ;)

PEACE!
 
You need to read a pharmacology text. Tolerance doesn't work like that. I'm assuming you're using a German translation from your usage of the word 'Neuroleptika' - in English it's "antipsychotic".

I haven't heard of people use antipsychotics to reduce tolerance to stimulants. If anything, they counteract the positive effects of them by antagonizing dopamine and are good for comedowns, or as industrial strength sedatives.

The big problem with benzodiazepine-site antagonists is that they, er, act like anti-benzos. So instead of muscle relaxant, anticonvulsants, and anxiolytics, you now have a drug that makes you stiff, twitchy, and irritable. Not to say they don't exist, but they have little use except in reversing overdose.

I don't see how you think ethylamine would be an antagonist if Fomepizole is an antidote for ethylene glycol poisoning. There's two different proteins at work there which I won't elaborate on.

A lot of people don't react well to alcohol, maybe it's just not your drug?

http://en.wikipedia.org/wiki/Flumazenil
http://www.ncbi.nlm.nih.gov/pubmed/2111915
 
c0rt3x said:
Neuroleptika
Click to expand...
I approve of this neologism! However, only insofar as the painfully sharp germanic k (nothing against germanic people - I love all of you, sexually may I add) is replaced with the more sensible, delicate c of the Romance vulgates: Neuroleptica, in the same vein as "Psychedelia" (though hopefully no needles are involved!).

=D

Erm, otherwise, all I can say is please head the advice above and get a better understanding of Pharmacology.

EDIT: Seiko - "Neuroleptica" would, IMO, make sense in English as it is constructed out of the same classical roots used to construct other English words. Observe these affixes: "neurology," "epileptic," "esoterica." That said it is always useful to point out the more commonly used english term, so I am not contradicting you - just trying to help establish a more pretty word that describes an otherwise-ugly class of drugs ;).
 
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English does have a word for it - 'neuroleptic'. Neuroleptics would therefore be to neuroleptica as psychedelics would be to psychedelia, I suppose. It would make a good name for a club - I can almost hear the unce, unce, unce...
 
sekio said:
English does have a word for it - 'neuroleptic'. Neuroleptics would therefore be to neuroleptica as psychedelics would be to psychedelia, I suppose. It would make a good name for a club - I can almost hear the unce, unce, unce...
Click to expand...

As long as we're being linguistic purists, neuroleptica should be neurolepsy.
 
Original poster:

1. Why do you think that you have hypersensitivity to GABA agonism?
2. Why do you think that the solution would be treatment with a GABA agonist?

Uses of anti-psychotics in treating stimulant dependence or ULD naltrexone with opioid addicts (and dissociatives for either) are highly experimental, with unknown mechanisms, likely distinct in each case. Furthermore, GABA antagonists (even in the case of allosteric modulators, let alone inverse agonists) are life-threateningly dangerous.

There cannot be an 'ethanol antagonist' because its spectrum of action is too wide...

This question is ill suited to ADD, but you guys made the thread fun. :P

ebola
 
What on earth is going on here? It looks like the ASCII fairly came and took a dump everywhere.

I would imagine a combination glutamate/NMDA and GABA agonist would be quite the excitotoxin.
 
C0rtex: I think you probably have something good to add. But please do so when you sober up a bit. I had to remove your posts because they add nothing to the discussion.
 
But alcohol also agonizes GABA B, antagonizes NMDA, specifically antagonizes some 5ht sites, alters membrane permeability, etc. I guess that this antagonist counteracts that part of ETOH's activity that kills. :P

ebola
 
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