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  • BDD Moderators: Keif’ Richards

Seroquel and hypnotics

Lemme put it like this. Seroquel = passed the fuck out. Seroquel + ambien/temazepam = coma. You decide your level of risk you wanna take.
 
Took 20 mg of ambien with 50 mg dosage of seroquel, skipped out on the the temazepam though. I'm coming down from a fairly high dose of amphetamines so I could use the sedation right now
 
im also interested with whether seroquel, which according to wiki is a strong antihistamine potentiates benzos/opiates.
 
I stayed up for a few hours on it and my motor skills were fucked and my vision was strange, it got somewhat trippy. I'd do it again, I found it entertaining late night when nothing was going on. I would definitely say it potentiates/or synergizes with ambien. Yeah it does say it's an antihistamine "At very low doses (<25 mg), quetiapine acts primarily as a histamine receptor blocker (antihistamine) and α1-adrenergic blocker." "This means Quetiapine is a dopamine, serotonin and adrenergic antagonist and a potent antihistamine with clinically negligible anticholinergic properties."
 
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Seroquel has very powerful antihistamine properties, much like, say, promethazine. This occurs at lower doses, as Escapedysphoria mentioned, before the more antipsychotic effects manifest themselves.

That being said, it is an excellent potentiator of opiates, simply due to its antihistamine properties. The problem with this is, it also knocks you out so quickly...you rarely have enough time to enjoy the opiates in the first place, unless you have a very high tolerance to the effects of Seroquel.

If you want to potentiate opiates, there are better options that aren't going to completely knock you out.

As far as potentiating sedative/hypnotic drugs, yes, it does, I guess. It's such a damn good sedative/hypnotic drug by itself that you're probably better off saving your Ambien or benzos. Unless you're really tweaking out and need to go to sleep or something.

My two cents: Save your opiates and your benzos/z-drugs for another day. If you really need to take Seroquel, just take Seroquel and be done with it. :/
 
Ah, I like this combo, I was doing it for like 3 nights in a row. I know, dumb. If you have a somewhat tolerance to Seroquel you can force yourself to stay awake and get trippy effects. You can end up doing really stupid things on this combo. Each night I'd end up on Bluelight typing really bizarre and stupid shit. But all in all if you are looking to just trip the fuck out and get really stupid then I'd say that this combo is for you.

The doses I took were 30mg Ambien and 50mg Seroquel. I don't suggest such dose to anybody. If someone was interested I'd suggest 10mg Ambien + 50mg Seroquel to start with. You don't need to worry about "severe" respiratory depression like you would with an opiate and benzodiazepine/alcohol combo. So its not deadly at lower doses but its possible you could do stuff you may black out or just simply pass out before you could feel any of the psychedelic effects.
 
Definitely some amnesia, but I remember a good portion of the night. Just small things like forgetting what you did 2 seconds ago or where you put your lighter or something.
 
25mg of seroquel can knock you the fuck out. Its powerful, and not recreational IMO. I wouldn't mix with opiates.

Seroquel gives me extreme restless leg syndrome. As soon as it gets unbearable, I'm passed out. It is so powerful, you can't fight the drowsiness that it gives you, and if you don't then you'll just end up feeling super shitty if you're still awake.

I would use your seroquel for emergencies only, like getting through W/D or coming down from amps.
 
^^^ that

I used it once for it's antihistamine properties after severe itching from dhc. It worked very well but I was dead asleep after two hours. Dosing at around 50 mg as I recall.
 
Dr Rxpert said:
I would imagine you would go into a coma induced state for many hours.
Click to expand...

No you don't. It can be quiet psychedelic as long as you can stay awake. If Seroquel knocks you out then you will probably just pass out but if your able to keep from going to sleep you can really trip out. It seems that Seroquel enhances the strange effects of Ambien. It lasts about 2 hours and then you can fall asleep when you want.
 
Seroquel is a powerful sedative and it causes hypotension (decrease in blood pressure). Mixing it with any sedative-hypnotics is dangerous and I'd advise against it.

However, everyone knows (or at least I hope they do) their tolerance, how much their body can handle, and how to take drugs safely.

However, I really think there are better and/or even 'safer' mixes for hypnotics than Seroquel.
 
Im prescribed clonazepam every day for anxiety and ive sometimes been prescribed seroquel to help with my bipolar disorder. I also take morphine for chronic pain and inspite of all this i still get fucking insomnia :! . Ive been prescribed zopiclone, temazepam and diazepam to help me sleep when taking a anti-psychotic dose of seroquel (my usual dose if im on it is 300-400mg's a day) and this is taken along with my daily doses of clonazepam which is 4-6mg's a day, really high doses of gabapentin and kinda lowish medium doses of morphine.

As you can imagine i have a pretty high tolerance for benzodiazepines and i have a high one for opiates as well. Seroquel does not make me drowsy after awile of being on it but it does potentiate the sedative effects of other CNS depressants quite abit atleast until you get tolerant to the anti-histaminic effects of the seroquel and this happens alot quicker then in some then others. The combo im on could kill a person not used to those drugs or atleast fuck them up beyond repair for a long time. So it's a question of tolerance really.

I don't find that seroquel really potentiaties opiates like the anti-histamines hydrozine, diphenhydramine, doxylamine or dimenhydrinate do. Seroquel does not even potentiate the painkilling effects of morphine or other opiates or help the nausea like the old phenothiazine type anti-psychotics such as chlorpromazine (good old largactil/thorazine) or methotrimeprazine does. Im only going by personal experience here though and i found 25mg's of thorazine with morphine to not be that bad and it was definetely good for it's anti-emetic effect. Granted i would never recomend anyone take thorazine or any other anti-psychotic without seing a doctor. Especially these old ones with a fuck load of side effects.

Even though promethazine is OTC in Canada i have yet to find a fucking drug store that has it in stock so i havent tried that phenothiazine anti-histamine yet.

Basically id just say fuck seroquel for potentiating hypnotics. I found it only to potentiate the negative side effects like dry mouth in the case of opiates not to mentioning overwelming the opiate buzz. As for taking it with a sedating benzo or a Z drug your just going to add alot to the knock out effect of both. So yeah it increases none of the good effects but it does increase some bad effects.
 
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I take Seroquel too - 100 mg at bedtime. That's in addition to my 1 mg alprazolam 3x a day, my dextroamphetamine 5 mg - 2 tabs in morning, 2 tabs in afternoon, 1 in evening, and 20 mg Cipralex once daily.

All the Seroquel does is knock me out. There's synergy with the alprazolam, but I certainly can't feel it because as soon as the Seroquel kicks in it's lights out for me.

It's just not a drug you mix with other downers - both dangerous and not worthwhile.
 
I can definitely vouch for the ambien + seroquel combo, i liked it and did notice odd sensory effects, relaxed body highs (smoked potent medical marijuana with the combo), and like I mentioned before it's definitely an altered state. It helps that ambien doesn't have much anxiolytic effects so it allows you to trip as opposed to temazepam. Each to their own though.
 
paranoid android said:
Im prescribed clonazepam every day for anxiety and ive sometimes been prescribed seroquel to help with my bipolar disorder. I also take morphine for chronic pain and inspite of all this i still get fucking insomnia :! . Ive been prescribed zopiclone, temazepam and diazepam to help me sleep when taking a anti-psychotic dose of seroquel (my usual dose if im on it is 300-400mg's a day) and this is taken along with my daily doses of clonazepam which is 4-6mg's a day, really high doses of gabapentin and kinda lowish medium doses of morphine.

As you can imagine i have a pretty high tolerance for benzodiazepines and i have a high one for opiates as well. Seroquel does not make me drowsy after awile of being on it but it does potentiate the sedative effects of other CNS depressants quite abit atleast until you get tolerant to the anti-histaminic effects of the seroquel and this happens alot quicker then in some then others. The combo im on could kill a person not used to those drugs or atleast fuck them up beyond repair for a long time. So it's a question of tolerance really.

I don't find that seroquel really potentiaties opiates like the anti-histamines hydrozine, diphenhydramine, doxylamine or dimenhydrinate do. Seroquel does not even potentiate the painkilling effects of morphine or other opiates or help the nausea like the old phenothiazine type anti-psychotics such as chlorpromazine (good old largactil/thorazine) or methotrimeprazine does. Im only going by personal experience here though and i found 25mg's of thorazine with morphine to not be that bad and it was definetely good for it's anti-emetic effect. Granted i would never recomend anyone take thorazine or any other anti-psychotic without seing a doctor. Especially these old ones with a fuck load of side effects.

Even though promethazine is OTC in Canada i have yet to find a fucking drug store that has it in stock so i havent tried that phenothiazine anti-histamine yet.

Basically id just say fuck seroquel for potentiating hypnotics. I found it only to potentiate the negative side effects like dry mouth in the case of opiates not to mentioning overwelming the opiate buzz. As for taking it with a sedating benzo or a Z drug your just going to add alot to the knock out effect of both. So yeah it increases none of the good effects but it does increase some bad effects.
Click to expand...

We're talking Ambien, not classical benzodiazepines or opiates. It doesn't increase the bad effects of Ambien, it increases the positive effects, although with Ambien there isn't much. You have to try it to know. But it does have to do with tolerance, if you aren't able to handle 50mg of Seroquel then your not going to be able to handle 50mg of Seroquel with whatever dose of Ambien. So you must already have a tolerance to Seroquel (or another antipsychotic I suppose would work) before trying this combo. Otherwise you'll just pass out and have a hard time waking up in the morning. Its not like this is some crazy fun combo that you can party with. Its just something to do if you want to feel kind of weird and tripped out before you pass out. The morning after sucks. But again, tolerance is important and also, even if you have done this with benzos and opiates with no success, it is different with Ambien due to the potential psychedelic effects. I was prescribed clonazepam with Seroquel for years and I never felt any different. So don't knock it until you've tried it.
 
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