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The science behind breaks?

LockedNLoaded said:
I've always had the theory that "losing the magic", while receptor downregulation or some such college talk probably plays a role, is actually the psychological experience of becoming familiar with the experience, like overlistening to a really awesome song. From that approach, the longer the break the better, because you have more time to "forget" all the great little facets of the experience.
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Agreed. I only roll a few times a year now, and when I do, I am always reminded of how great it is. The afterglow is nice and I find myself basking in how great it was for a little bit, but it slowly starts to fade with time and I find that after a few months I've almost forgotten what it feels like, and stopped thinking about it. Then, when I roll again I have the "oh yeah.... this is what it's like" feelings. I personally feel best when I've waited until I've forgotten the feeling for a while.
 
foxyloxy55 said:
Agreed. I only roll a few times a year now, and when I do, I am always reminded of how great it is. The afterglow is nice and I find myself basking in how great it was for a little bit, but it slowly starts to fade with time and I find that after a few months I've almost forgotten what it feels like, and stopped thinking about it. Then, when I roll again I have the "oh yeah.... this is what it's like" feelings. I personally feel best when I've waited until I've forgotten the feeling for a while.
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how often is 'a few times a year'?
 
TearItDown said:
You are wrong.

^ King MW. "Serotonin". The Medical Biochemistry Page. Indiana University School of Medicine. Retrieved 2009-12-01.


^ Berger M, Gray JA, Roth BL (2009). "The expanded biology of serotonin". Annu. Rev. Med. 60: 355–66. doi:10.1146/annurev.med.60.042307.110802. PMID 19630576.

fuck off troll
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Not only are you wrong, but you took the quote out of context. That sources say NOTHING about the conversion of serotonin, it only says where most serotonin is stored in your body.

"Approximately 80 percent of the human body's total serotonin is located in the enterochromaffin cells in the gut, where it is used to regulate intestinal movements." Taken right off the Wikipedia page and all you did was grab the first two sources. You've lost all credibility because you couldn't even find a source to use in the proper context.

Since one can assume that we don't use much of gut's serotonin on MDMA, when our brains are depleted of the neurotransmitter, our body quickly tries to re-normalize itself by creating more brain serotonin. Why would our body store serotonin in our gut if it's not needed there?

Before you get all worked up, please do more than just grab the first two sources you can find at the botton of a Wikipedia article, and for God's sake, stop taking stuff out of context.
 
roganmaster said:
Not only are you wrong, but you took the quote out of context. That sources say NOTHING about the conversion of serotonin, it only says where most serotonin is stored in your body.

"Approximately 80 percent of the human body's total serotonin is located in the enterochromaffin cells in the gut, where it is used to regulate intestinal movements." Taken right off the Wikipedia page and all you did was grab the first two sources. You've lost all credibility because you couldn't even find a source to use in the proper context.

Since one can assume that we don't use much of gut's serotonin on MDMA, when our brains are depleted of the neurotransmitter, our body quickly tries to re-normalize itself by creating more brain serotonin. Why would our body store serotonin in our gut if it's not needed there?

Before you get all worked up, please do more than just grab the first two sources you can find at the botton of a Wikipedia article, and for God's sake, stop taking stuff out of context.
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yeah, two sources out of a wikipedia article. that's how easy it was to debunk your statements. jfgi next time before you make unsupported claims.
 
TearItDown said:
yeah, two sources out of a wikipedia article. that's how easy it was to debunk your statements. jfgi next time before you make unsupported claims.
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Lol you debunked nothing. Those quotes didn't support any of your claims! You just pulled two random sources that had nothing to do with the argument at hand.
 
Exposing your serotonin receptors with a flood of serotonin causes them to downregulate (withdrawing from the synapse and into the cell).. It takes time for these recptors to upregulate again..
 
rickolasnice said:
Exposing your serotonin receptors with a flood of serotonin causes them to downregulate (withdrawing from the synapse and into the cell).. It takes time for these recptors to upregulate again..
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They down regulate for a day. The day after your brain figures out that there is too much serotonin in the brain.

And rogan:
If 80% of the serotonin in our body is located in the gut (as you now know), what do you think that means for the remaining %? What I said was completely in context. Your high tryptophan diet only improves your serotonin levels for rolling by 20%. idk what you're smoking dude.
 
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