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How toxic is Mephedrone?

Hi Folks, having just come off my usual mix of mephedrone and methylone I thought my experience might be of some interest. I'm in my mid fifties and really should be past it but about a year ago when the Media started shouting about headshops, and how their products really worked, I had a hankering after my younger days of cannabis and acid (mushies when acid wasn't available) and ordered a gram of each on the net. As anyone reading this can guess my mind, which had been clean for many years was totally blown! I couldn't believe it! Something this good was being delivered to my door by the postman. I quickly ordered 30g of each which duly arrived and I felt I was the happiest person in the world. My mix was 125mg of each and I figured that if I did this twice a month my stash would last me 10 years. For 4 or 5 months I actually kept to this but I eventually got to like it too much. I progressively did more and more and finally blew the final 30g in the last 10 weeks. My neck is still a bit sore, my lower back is a bit sore, (I finished the last gram 2 days ago) and I broke a filling in a tooth from gurning at the beginning, since fixed by the dentist. I do not regret a single minute of the experience, which I believe that I will not repeat, but I have enormous sympathy for the younger people whose supply is not limited like mine was and are developing addiction problems. Although I have always felt myself to be completely in control of my substance intake these drugs showed me that I was not. Apologies if I've bored anyone and take care.:\
 
I should also note that after my flephedrone incident last summer, i started getting several allergic reactions to random recreational substances i took, even when i tried baclofen, also on desoxy i noticed i had the blue knee syndrome, wich other ppl have also reported to come back (in my case first time i had it tough) after they try another stimulant unrelated to mephedrone.

After 2 weeks i didnt get any random allergy's anymore.

Either way, flephedrone isnt free of those side effects as first tought.

This was never reported with mephedrone, but its likely 4 fluoro ephedrine has distinct toxiticy issues.
 
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Does 5HT2B agonism cause inflammation acutely? My understanding was that only months of chronic exposure cause fibrosis, and thus likely not behind the adverse reaction we see with mephedrone.
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Many of these reactions appear based on chronic exposure. Hypersensitization to future acute exposure to irritants seems common with auto-immune disorders.

ebola
 
This reaction doesnt really look like a real allergy tough, having experienced allergy's they cause hives wich look completely differend and also causes a major itch, wich wasnt the case here or last time.
Also the fact that some of this reaction comes back on other stim suggests that this isnt a response to a sensitized allergen.

Chronic, in the short term, once the metabolites reach high enough concentrations those problems appear to occur, in my case this was both after a high dose with flephedrone and mephedrone (with lower doses on other occasions not causing any reactions, tough i only used mephedrone 4 times or something). For fibrosis you need to be exposed for weeks atleast.
 
MeDieViL said:
This reaction doesnt really look like a real allergy tough, having experienced allergy's they cause hives wich look completely differend and also causes a major itch, wich wasnt the case here or last time.
Also the fact that some of this reaction comes back on other stim suggests that this isnt a response to a sensitized allergen.

Chronic, in the short term, once the metabolites reach high enough concentrations those problems appear to occur, in my case this was both after a high dose with flephedrone and mephedrone (with lower doses on other occasions not causing any reactions, tough i only used mephedrone 4 times or something). For fibrosis you need to be exposed for weeks atleast.
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MeDieViL said:
I should also note that after my flephedrone incident last summer, i started getting several allergic reactions to random recreational substances i took, even when i tried baclofen, also on desoxy i noticed i had the blue knee syndrome, wich other ppl have also reported to come back (in my case first time i had it tough) after they try another stimulant unrelated to mephedrone.

After 2 weeks i didnt get any random allergy's anymore.

Either way, flephedrone isnt free of those side effects as first tought.

This was never reported with mephedrone, but its likely 4 fluoro ephedrine has distinct toxiticy issues.
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Wewt someone else from Belgium who has heard from Desoxy . Thanks for sharing your experience with it. I sparingly use amphetamines (and therefore I binge) thus this substance has lost all of it's appeal because of it's fiendish behaviour.
 
Didnt take anymore mephedrone and after several hours cleared up completely, i assume when the metabolite left my body, i did end up taking other drugs later without any negative effects. (which may have had positive effects because of imunosupression?) either way i'm 100% fine now, i beleive that if i kept on taking mephedrone i could have gotten a much worse reaction and possibly the same issue with it coming back later).
 
vecktor said:
congratulations lab rat, looks like you have discovered that abscence of evidence of harm is not evidence of the abscence of harm.

sounds like vasoconstriction, perhaps due to alpha adrenergic activity of the hydroxy metabolite, and if your limbs don't actually die or have to be amputated they will recover eventually.

breathing deeply makes no difference, the tissue oxygen levels are not going to be much effected, because the oxygenated blood is not getting where it should, deep breathing can cause other problems due to hyperventilation.

this drug and its parafluoro relative should be left alone, it appears to have killed at least once and is responsible for hospitalisations in the UK.

just so you know what vasoconstriction caused by RC's looks like:

Bild1.jpg

Bild2.jpg


the toxicology profile of mephedrone at the moment seems very similar to that of PMMA paramethoxymethamphetamine and PMA which has killed scores of people.

I make no apology for posting these images (incidentally they are from a bromodragonfly overdose) if it stops one person from dying.

taking these things is always a gamble but the downside risks in this game can be very high, if you treat these things as harmless fun and don't afford them the respect they deserve, then you can be severely hurt.
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um....that second picture is of a laceration isnt it?
 
the second picture is of an amputation that occurred when someone overdosed on Bromo Dragonfly, im not sure if it had to do with vasoconstriction or not.

whats the first picture?
 
sackynut said:
the second picture is of an amputation that occurred when someone overdosed on Bromo Dragonfly, im not sure if it had to do with vasoconstriction or not.

whats the first picture?
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so why did they amputate it? so they had ALREADY didnt have half his fingers then he got a huge cut on his hand? like was that a accident that happened becuase he/she was dealing with knifes or something, or somehow its directly connected to the bromodf?
 
^ i believe the BrDrgonfly caused such intense vasoconsctriction that if they didnt amputate, it would have fucked some shit up HARDCORE in his hand/body, possibly leading to death? dont quote me on that though, i tried looking for thread on another board but didnt find it after a quick search.

im pretty sure it had nothing to do with him taking a knife to his hand while tripping, it was just adverse physical side effects.

ive taken very large amounts of meph, in binged too (ive since stopped, its nasty stuff) and while I experienced same major heart trauma, breathing problems and fatigue, i never once noticed vasoconstriction, no purple or blue extremities, and my veins were still gigantic as ever (big veins runs in the family). perhaps vasoconstriction and 5ht2b agonism/heart issues arise from different amounts and types of impurities?
 
basically i used to think meph didn't turn me blue, but then last year new years eve i had a binge to end all binges and after taking about 8 grams over a number of days i started to get the blue skin and thing where skin on my lips and feet were peeling off. enough to put me off since
 
I never had any of the blue skin. I actually had 2 different batches of meph, the first one had a really strong smell and although i had no blue skin i did notice pins and needles from time to time in my hands and even more rarely feet.

The second batch i had had no smell what so ever, i was even unsure if it was meph when it landed on my doorstep, after using though i am sure it was. All the same effects but not once did i get pins and needles.

This does make me think it may have been down to impuritites.

A hell of a lot of people slag meph off and tell people to get some "real" drugs, I have tried a range of real drugs ranging from Coke (Powder and Crack) - MDMA- LSD - Apmetamines - Etc , and im still of the opinion that meph was my favourite drug by far, it still pisses me off now that because of the way use exploded, kids started taking it and the media jumped on it that it got banned.

I just wish i had bought a large amount to store for personal use before the ban, i have had emails since the ban from a company i have bought from telling me they have meph still but theres just no way in a million years i would risk that now. Even if it were not a scam the risks must be massive.
 
ive been doing meph for years, i still miss the decent pre-ban stuff. however the side effects are nasty, the come down is fucking brutal, ive had red/purpley hands, pins and needles, waking up with numb hands, heart palps, anxiety, depression, paranoia. this is from half a gram once a week on a saturday night for years. the high is incredible, meph is amazing when you get decent stuff. i used to combine it with alcohol and have some incredible nights. no memory loss, a state of perfection. now i try and avoid it, but the sad fact is whenever im drunk i crave meph, alcohol on its own is like tits without nipples.... its not right. its ok but its not enough
 
BoomBoxer said:
I never had any of the blue skin. I actually had 2 different batches of meph, the first one had a really strong smell and although i had no blue skin i did notice pins and needles from time to time in my hands and even more rarely feet.

The second batch i had had no smell what so ever, i was even unsure if it was meph when it landed on my doorstep, after using though i am sure it was. All the same effects but not once did i get pins and needles.

This does make me think it may have been down to impuritites.

A hell of a lot of people slag meph off and tell people to get some "real" drugs, I have tried a range of real drugs ranging from Coke (Powder and Crack) - MDMA- LSD - Apmetamines - Etc , and im still of the opinion that meph was my favourite drug by far, it still pisses me off now that because of the way use exploded, kids started taking it and the media jumped on it that it got banned.

I just wish i had bought a large amount to store for personal use before the ban, i have had emails since the ban from a company i have bought from telling me they have meph still but theres just no way in a million years i would risk that now. Even if it were not a scam the risks must be massive.
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the more often you take it the more you will notice side effects. i took it for years and it crept up to seeing the dodgy sides of it.

dont miss it one bit...
 
I certainly felt the side effects crept up after a few weeks of regular use... but that's why I've always taken long breaks of 2-3 months after my use creeped up over a month or so.

I hadn't used any since the ban until November and to be honest, I didn't get that much side effects at all. Was only after a couple of weeks heavy use that the brutal comedown, feeling sick and mild vasoconstriction came back. I never really ever got blue/purple knees or lips. There was one weekend where I went through 6-7g and my friend said my lips were a little blue but it cleared up after a small break and food and despite the fact I was up into the following evening on Meph; it never appeared back.

There's no doubt that regular use seems to increase the severity of side effects though.

I'm much the same ColtDan - I still find myself craving it usually after the dissapointment at the other drugs I can find which really just don't hit the spot the same. Either that or halfway through nights where I'm out & only drinking. Not as often now but enough to try get my hands on some once in a while.

Just realised bit off-topic for ADD but still that's my experience.
 
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pofacedhoe said:
basically i used to think meph didn't turn me blue, but then last year new years eve i had a binge to end all binges and after taking about 8 grams over a number of days i started to get the blue skin and thing where skin on my lips and feet were peeling off. enough to put me off since
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Yes, it does peel of skin, it even happened on my tongue, the mephedrone problems are definatly autoimunity related and have little to do with vasoconstriction.
 
Could someone explain the idea behind these side-effects being an auto-immune response? Does this have anything to do with the suspected sensitization of the adrenergic system (was this suspected up or down regulation, I forget now...)? Is it basically the body over-compensating for the presence of a substance that it dislikes, kind of like an allergy? It just confuses me what people mean by 'auto-immune' response and why. What other drugs have shown an auto-immune response profile similar to Mephedrone (I assume there must be some precedence for these claims)?

Thanks.

Oh and for what it is worth, quitting smoking has now 100% cleaned up my lingering red knuckles that came about through/during Mephedrone abuse. I quit Mephedrone in May 2010 and at that time my first and second knuckles on both hands were almost always bright red, then after a month or two off it was just the first knuckle that was red, around New Years things were clearing up a bit further, just my index and middle finger knuckles. Quit smoking 2-3 weeks ago and I noticed any remaining discolouration cleared up almost instantly. So it seems that had I quit Tobacco earlier I probably wouldn't have had quite as prolonged discolouration. After abusing Mephedrone, every stimulant I have tried has had far more severe and discomforting side effects, fewer positive effects, far worse come downs, and far more vasoconstriction than I experienced on the same stimulants before abusing Mephedrone. Even Tobacco it seems was victim to this, though it wasn't until I quit that I realized I had Tobacco to blame for some daily discomforts. Oddly however, MDMA is one exception to this. I've used it 3 times since quitting Mephedrone, with minimal negative side-effects, minimal comedown, etc.
 
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@Sackynut: is this the story you're referring to with the Bromo-Dragonfly?

Since starting a regular meph habit, I've noticed some strange skin issues, though not likely due to vasoconstriction.

1.--I react to poppy tea as if I'm highly allergic now. My chest gets flushed with red splotches and my eyes swell like I've been beaten. Only when I combine low dose poppy tea with mephedrone though. I also itch like mad on opiates where I NEVER itched before. I do fine with one or the other, but the combination does not go over well in my body.

2. My lips, scalp and hands are peeling. Like, flaking off and peeling. Mephedrone makes my scalp itch like crazy and produce big dandruff pieces (ew) that I've never encountered before.

I feel way more vasoconstriction with propylhexedrine and even caffeine than I do with meph, though I can tell it's far from harmless. I don't dare combine it with even mild stims like caffeine, as this leads to strange chest pains that aren't severe but enough to notice.
 
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