Tianeptine - Your experience

[QuasiModo]

Want to hear from anyone currently or has taken Tianeptine (Stablon).

I am interested in its nootropic, neuroprotective and anxylotic properties. Seems very interesting.

 

[mad_scientist]

Highly effective and rapidly acting antidepressant, moderate anxiolytic, didn't notice any nootropic effects. Tolerance builds rapidly and will lose efficacy after only a couple weeks of daily use, need regular breaks to continue working long term.

Higher doses can be taken for recreational effect but never really gets that strong, found that doses over a couple hundred milligrams caused headaches so never tried the still higher dose ranges that supposedly produce opioid-like effects. However regular use does start to produce some opioid like side effects so I'd tend to believe the Russian reports about IV use etc.

 

[helium-4]

I started to become interested in this drug especially because the lack of binding to 5-htxx's, and reuptake of 5-ht, with the modulatory effect on glutamate receptors (AMPA and NMDA). As someone who deals with stress issues daily, the "normalization" of glutamate receptors, by restoring the amplitude of NMDA receptors to AMPA/Kainate receptor mediated currents in the hippocampal and amygdaloid region of the brain, is very intriguing. Also it's beneficial effects on cognitive and memory functions, tied possibly to the neurogenesis and LTP of neuron with in the hippocampus is lovely to see. I've become very interested in the modulation of NMDAr's (better yet, glutamate receptors in general), and this ones strike me due to it's ability to induce such responses with out being a receptor ligand of any know neurotransmitter sites, with minimal alteration of receptor binding affinity.

I found this the other day, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902200/?tool=pmcentrez

Good read for anyone interested in it.

 

[Jackinbox]

It make you feel happy very fast but doesn't last long. I needed to take about 3 times the normal dose to have an effect. I couldn't take it more than one day since it make me so constipated.

 

[QuasiModo]

Hmm, anyone know how long it takes for tolerance to hit baseline? I was thinking originally of buying a half KG to see how I like it.... Take it on the work week and t-break on weekends. If two days kills tolerance this could be a very useful drug for me.

 

[Hammilton]

You were going to buy 500 grams of a drug you've not even tried, and that has a starting dose around 12.5mg? How many weekends do you think you're gonna have? Even if you were taking 50mg doses (if you're taking it on weekends only, I would imagine that your tolerance would not climb substantially), that's 10000 weekend days. Hell, even if you were taking 50mg 3x per day every saturday and sunday, you'd have 1666 weekends worth. Figuring 52 weekends per year, you'd have enough for 33 years worth!

 

[amanitadine]

I believe they said they were to buy 500g "to see how they like it". The real bulk purchase will come later....

 

[QuasiModo]

No no, you have it backwards. I am planning on purchasing 500g for the WORK WEEK as in monday-friday. Saturday and Sunday would be my tolerance break days.

 

[allium]

What is the point for taking something for a long period of time?
Did you already try it, and did you like it?

BTW, Tianeptine(sold under brand name Coaxil) was widely abused in Russia. People got terrible necrosis, because Coaxil pill contain insoluble components(like SiO2 and maybe some others). I would be very cautious taking Tianeptine, because of abuse potential.

 

[QuasiModo]

What is the point for taking something for a long period of time?
Did you already try it, and did you like it?

BTW, Tianeptine(sold under brand name Coaxil) was widely abused in Russia. People got terrible necrosis, because Coaxil pill contain insoluble components(like SiO2 and maybe some others). I would be very cautious taking Tianeptine, because of abuse potential.

Really? Dude I live in California if I wanted an opiate effect I would be buying heroin. I'm purchasing a half kg to self medicate my depression as Tianeptine has a much lower side effect profile than other antidepressants, as well as not causing cognitive/memory impairment which is unacceptable for school. Seriously I am slightly offended that you would imply myself having intentions of abusing (intravenously no less!) an antidepressant, shame on you.

 

[ektamine]

BTW, Tianeptine(sold under brand name Coaxil) was widely abused in Russia. People got terrible necrosis, because Coaxil pill contain insoluble components(like SiO2 and maybe some others). I would be very cautious taking Tianeptine, because of abuse potential.

Oh god, thats what those videos were of the russians with black rotting feet / legs was about wasn't it? I vaguely remember seeing a comment saying something along the lines of "What idiots! don't they know its an anti-depressant?' or something.

The drug itself looks fairly interesting for therapeutic potential. Dose anyone have personal experience using it regularly at therapeutic doses?

 

[SKL]

Using regularly, no, but I've tried it, as others have said, it rapidly produces euthymia (not so much euphoria) but is rather short acting. It is hard to describe the effects, I would not really call it a high, but rather, a genuine anti-depressent. I can easily believe that it looses efficacy over time, though.

I think the Russians were using pretty substantial doses i.v. and all that. Interesting. And if it's available in pure form (I assume that's what the poster buying 500g of it is referencing) I don't know that the injection complications mentioned above would necessarily be a significant factor, as they seem to be derived from the shooting of pills rather than the compound itself.

But yeah, tianeptine is interesting stuff. Sort of like the crack of anti-depressants. Very dramatic effect but short lived, and compulsive in some.

 

[allium]

Oh god, thats what those videos were of the russians with black rotting feet / legs was about wasn't it?

Yeah, probably. I haven't seen any videos though, but saw some terrible photos(use images.google.com by copy and pastign word Коаксил, if you want to see some).
It is said that Tianeptin produces opiate-like feeling when used intravenously. This sounds verisimilar, because people don't shoot drugs without a reason.

Sorry, if my posts are offtopic.

^ You are right about dangers coming from IVing pills, but addiction/abuse potential itself isn't something really desirable.

 

[ektamine]

Using regularly, no, but I've tried it, as others have said, it rapidly produces euthymia (not so much euphoria) but is rather short acting. It is hard to describe the effects, I would not really call it a high, but rather, a genuine anti-depressent. I can easily believe that it looses efficacy over time, though.

I think the Russians were using pretty substantial doses i.v. and all that. Interesting. And if it's available in pure form (I assume that's what the poster buying 500g of it is referencing) I don't know that the injection complications mentioned above would necessarily be a significant factor, as they seem to be derived from the shooting of pills rather than the compound itself.

But yeah, tianeptine is interesting stuff. Sort of like the crack of anti-depressants. Very dramatic effect but short lived, and compulsive in some.

Huh. That makes it sound even more interesting to me, but dangerous when applied therapeutically to the depressed, as it does sound like a 'more-ish' anti-depressant, which surely can't be all that good.

 

[SKL]

There is a case in the literature of someone who was taking hundreds of pills a day and required inpatient detoxification.

 

[QuasiModo]

Using regularly, no, but I've tried it, as others have said, it rapidly produces euthymia (not so much euphoria) but is rather short acting. It is hard to describe the effects, I would not really call it a high, but rather, a genuine anti-depressent. I can easily believe that it looses efficacy over time, though.

I think the Russians were using pretty substantial doses i.v. and all that. Interesting. And if it's available in pure form (I assume that's what the poster buying 500g of it is referencing) I don't know that the injection complications mentioned above would necessarily be a significant factor, as they seem to be derived from the shooting of pills rather than the compound itself.

But yeah, tianeptine is interesting stuff. Sort of like the crack of anti-depressants. Very dramatic effect but short lived, and compulsive in some.

It is available in pure form but only in KG quantities at this time. I really hope I am not inspiring somie fiends to start abusing this shit as if it became scheduled I would no longer be able to import it legally.... Damn that would be a huge backfire lol.

 

[QuasiModo]

Yeah, probably. I haven't seen any videos though, but saw some terrible photos(use images.google.com by copy and pastign word Коаксил, if you want to see some).
It is said that Tianeptin produces opiate-like feeling when used intravenously. This sounds verisimilar, because people don't shoot drugs without a reason.

Sorry, if my posts are offtopic.

^ You are right about dangers coming from IVing pills, but addiction/abuse potential itself isn't something really desirable.

People can abuse anything, caffiene can be abused. Obviously this is not my intention.

 

[QuasiModo]

I think this compound has vast untapped theraputic potential. From what I read combined with a workout regimine and a healthy diet can cure, rather than medicate, depression. I'm honestly not all that depressed anymore but would still like to test this chemical and see if it is beneficial. Maybe even give it to friends who are also depressed. Seems a shame that a compound with such an effect profile is not available to the US.

 

[allium]

People can abuse anything, caffiene can be abused.

Caffeine is the most addictive stimulant for me, altough I tried only few stims(MDPV, 3-FMC and some others), and I abuse it. I believe that most people don't realize that they are dependant on caffeine just because they consume it daily. So not a really good comparison.

Obviously this is not my intention.

Are you sure that you won't change your intentions when you try it?
Anyhow, it's your choice, and all I wanted is to share some possible useful information.

 

[QuasiModo]

I kicked dilaudid I don't think I'll have a problem not using something like this recreationally. I have plenty of other substances in my stash to use that way

Got some methoxetamine I aint touching cuz I don't want Olney's lesions. Maybe once it is studied further, just can't put my brain at risk that way..... Far too valuable to me.